Real Life Pharmacology - Pharmacology Education for Health Care Professionals

By Eric Christianson, PharmD; Pharmacology Expert and Clinical PharmacistMedicine Health & Fitness Education

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Real Life Pharmacology - Pharmacology Education for Health Care Professionals episodes

September 12, 2019 Acyclovir Pharmacology
On this episode "Acyclovir Pharmacology" I discuss the mechanism of action, important monitoring parameters, and drug interactions with acyclovir.

I discuss why acyclovir has to be dosed so many times per day.

Acyclovir can inhibit CYP1A2 which can impact a few drugs. I discuss a couple of those examples on this podcast episode.

GI effects are one of the more common side effects of acyclovir.

Rarely, neuropathy and nephropathy can be part of the adverse effect profile of acyclovir. I discuss this further on this episode.
18 min
September 05, 2019 Benzodiazepine Pharmacology
Benzodiazepines act by enhancing the effect of GABA, an inhibitory neurotransmitter.
Benzodiazepines can cause confusion, sedation, and respiratory depression.
There are many potential indications for benzodiazepines. They can be used in anxiety, status epilepticus, insomnia, and alcohol withdrawal amongst other things.
There is a boxed warning for the use of opioids with benzodiazepines. The primary risk of the combination is respiratory depression.
14 min
September 05, 2019 Benzodiazepine Pharmacology
Benzodiazepines act by enhancing the effect of GABA, an inhibitory neurotransmitter.

Benzodiazepines can cause confusion, sedation, and respiratory depression.

There are many potential indications for benzodiazepines. They can be used in anxiety, status epilepticus, insomnia, and alcohol withdrawal amongst other things.

There is a boxed warning for the use of opioids with benzodiazepines. The primary risk of the combination is respiratory depression.
14 min
August 29, 2019 Celecoxib Pharmacology
Celecoxib is easy to remember as its mechanism of action is “COX”-2 Inhibition. This can result in result in reduced prostaglandin formation and help with pain and inflammation.
Kidney function is important to monitor in our patient on celecoxib. It is especially important in patients taking ACE inhibitors, ARBs, and/or diuretics.
While GI bleed may be less likely with celecoxib compared to traditional NSAIDs like indomethacin and ibuprofen, it still needs to be monitored for.
Digoxin concentrations may be increased with the use of celecoxib.
Celecoxib is generally dosed twice per day as the half-life of the drug is in the ballpark of 10-12 hours.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

12 min
August 29, 2019 Celecoxib Pharmacology
Celecoxib is easy to remember as its mechanism of action is "COX"-2 Inhibition. This can result in result in reduced prostaglandin formation and help with pain and inflammation.

Kidney function is important to monitor in our patient on celecoxib. It is especially important in patients taking ACE inhibitors, ARBs, and/or diuretics.

While GI bleed may be less likely with celecoxib compared to traditional NSAIDs like indomethacin and ibuprofen, it still needs to be monitored for.

Digoxin concentrations may be increased with the use of celecoxib.

Celecoxib is generally dosed twice per day as the half-life of the drug is in the ballpark of 10-12 hours.
12 min
August 22, 2019 Oseltamivir Pharmacology
Oseltamivir is an antiviral agent that is indicated for the treatment and prophylaxis of influenza.
It is important to remember that oseltamivir is cleared at least in part by the kidney and dose adjustments should be made based upon kidney function.
There is a low potential that oseltamivir could contribute to psych issues like delirium.
Probenecid has the potential to raise the concentrations of oseltamivir.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

14 min
August 15, 2019 Dolutegravir
Dolutegravir is an integrase inhibitor that is used in the management of HIV infection/
Carbamazepine along with other enzyme inducers can substantially lower the concentrations of dolutegravir.
Dolutegravir can potentially increase blood sugars, this should be closely monitored in our patients with diabetes.
CNS adverse effects like insomnia and dizziness can happen with dolutegravir.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

11 min
August 15, 2019 Dolutegravir
Dolutegravir is an integrase inhibitor that is used in the management of HIV infection/

Carbamazepine along with other enzyme inducers can substantially lower the concentrations of dolutegravir.

Dolutegravir can potentially increase blood sugars, this should be closely monitored in our patients with diabetes.

CNS adverse effects like insomnia and dizziness can happen with dolutegravir.
11 min
August 08, 2019 Medroxyprogesterone Acetate Injection Pharmacology
On this podcast episode, I cover medroxyprogesterone acetate injection pharmacology (DMPA or Depo-Provera)
Medroxyprogesterone acetate injection is given every three months for the prevention of pregnancy.
Medroxyprogesterone acetate has a boxed warning for its risk of causing low bone mineral density.
Classic enzyme inducers can cause lower concentrations of medroxyprogesterone which can potentially lead to contraceptive failure.
Examples of enzyme inducers that can lower concentrations of medroxyprogesterone include carbamazepine, phenytoin, rifampin, and some agents used in the management of HIV.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

14 min
August 08, 2019 Medroxyprogesterone Acetate Injection Pharmacology
On this podcast episode, I cover medroxyprogesterone acetate injection pharmacology (DMPA or Depo-Provera)

Medroxyprogesterone acetate injection is given every three months for the prevention of pregnancy.

Medroxyprogesterone acetate has a boxed warning for its risk of causing low bone mineral density.

Classic enzyme inducers can cause lower concentrations of medroxyprogesterone which can potentially lead to contraceptive failure.

Examples of enzyme inducers that can lower concentrations of medroxyprogesterone include carbamazepine, phenytoin, rifampin, and some agents used in the management of HIV.
14 min