June 12, 2025

S4 Ep178: The Impact of Hormone Therapy on DCIS with Dr. Swati Kulkarni

47 minutes

Women are generally told that if they have a breast cancer diagnosis, they should steer clear of estrogen. In this episode, I have a conversation with Dr. Swati Kulkarni, the lead investigator of a new study in which women with a newly diagnosed breast ductal carcinoma in situ, DCIS, were given a month’s worth of hormone therapy before standard treatment to see the impact it would have on developing cancer cells.

What DCIS is and how it is typically diagnosed.

If DCIS is considered to be a pre-cancer or a cancer

If DCIS is untreated, how often it will progress to invasive cancer

If treated, how often women with DCIS go on to develop invasive cancer?

Why this particular form of hormone therapy, conjugated estrogens and bazodoxifene (Duovee™) was used in the study

The details of the study

The results of the study

The Promise Study: A presurgical randomized clinical trial of CE/BZA vs placebo in postmenopausal women with ductal carcinoma in situ.

Link to Abstract

My summary of the study on Substack

https://drstreicher.substack.com/p/can-hormone-therapy-shrink-breast

Link to Kagan episode on Duovee with Dr. Kagan

Episode 124 All Hormones Are Not Created Equal with Dr. James Simon

Dr. Streicher is on SUBSTACK DrStreicher.Substack.com

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Lauren Streicher MD, is a clinical professor of obstetrics and gynecology at Northwestern University’s Feinberg School of Medicine, the founding medical director of the Northwestern Medicine Center for Sexual Medicine and Menopause, and a Senior Research Fellow of The Kinsey Institute, Indiana University. She is a certified menopause practitioner of The Menopause Society. She is the Medical Director of Community Education and Outreach for Midi Health.

Dr. Streicher is the medical correspondent for Chicago’s top-rated news program, the WGN Morning News, and has been seen on The Today Show, Good Morning America, The Oprah Winfrey Show, CNN, NPR, Dr. Radio, Nightline, Fox and Friends, The Steve Harvey Show, CBS This Morning, ABC News Now, NBCNightlyNews,20/20, and World News Tonight. She is an expert source for many magazines and serves on the medical advisory board of The Kinsey Institute, Self Magazine, and Prevention Magazine. She writes a regular column for The Ethel by AARP and Prevention Magazine.

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BOOKS by Lauren Streicher, MD

Slip Sliding Away: Turning Back the Clock on Your Vagina-A gynecologist’s guide to eliminating post-menopause dryness and pain

Hot Flash Hell: A Gynecologist's Guide to Turning Down the Heat

Sex Rx- Hormones, Health, and Your Best Sex Ever

The Essential Guide to Hysterectomy

Dr. Streicher’s Inside Information podcast is for education and information and is not intended to replace medical advice from your personal healthcare clinician. Dr. Streicher disclaims liability for any medical outcomes that may occur because of applying methods suggested or discussed in this podcast.