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In this episode of Skin Anarchy, Dr. Ekta Yadav welcomes Carolina Reis Oliveira and Alessandra Zonari, co-founders of OneSkin, for a rigorous, eye-opening conversation that reframes skincare as a true longevity intervention. Part of the Lessons in Longevity series, this episode asks a bold question: what if skin aging isn’t cosmetic at all—but cellular, systemic, and deeply biological?

OneSkin began not as a brand, but as a lab-based mission. Trained in stem cell biology, tissue engineering, and genomics, Carolina and Alessandra spent years growing real human skin in the lab to test existing products. What they found challenged the industry: many so-called “anti-aging” formulas increased inflammation, cellular stress, and long-term damage. Meanwhile, longevity science was accelerating—yet skin, the body’s largest organ, was being left out of the conversation.

At the center of the episode is cellular senescence—a state where damaged cells stop dividing and begin secreting inflammatory signals that degrade surrounding tissue. In skin, this process weakens the barrier, disrupts collagen, and accelerates visible aging. Rather than masking symptoms, OneSkin set out to target this root cause. After screening hundreds of compounds, they developed OS-01, a proprietary peptide shown in lab models to significantly reduce senescent cell burden while increasing collagen—without irritation.

The conversation also expands beyond the face. OneSkin’s decision to focus on body skin revealed something unexpected: improving the skin barrier may reduce systemic inflammation. Clinical data discussed in the episode suggests that healthier skin doesn’t just look better—it may influence whole-body aging.

This episode is a must-listen for anyone curious about where skincare, biotech, and longevity science truly intersect.

Listen to the full episode of Skin Anarchy to hear how OneSkin is redefining skin as a living organ—and why the future of longevity may start at the surface.

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In this Fragrance Friday episode of Skin Anarchy, Dr. Ekta sits down with Pissara Umavijani, founder and perfumer of Parfums Dusita, for a quietly powerful conversation about perfume as emotion, memory, and meaning. In an industry increasingly driven by trends and virality, Dusita stands apart as a house built on poetry, patience, and feeling.

Pissara shares her deeply personal journey—leaving Thailand to start over in Paris with a singular intention: to create fragrance that makes people feel. Entirely self-taught, she immersed herself in the craft of perfumery through persistence and intuition, guided by a belief that scent should communicate something human, not perform for attention. Even the name Dusita, which refers to a level of paradise in Thai culture, reflects this ethos—living with purpose, warmth, and emotional presence.

Rather than relying on obvious cultural motifs, Dusita expresses Thai heritage through values: gentleness, hospitality, compassion, and balance. These qualities shape not only the fragrances themselves, but how the brand engages with people—inviting closeness rather than spectacle.

At the heart of every Dusita fragrance is poetry written by Pissara’s late father. Each poem serves as an emotional blueprint, translated into scent rather than illustrated literally. This approach comes to life in beloved creations like Tonka Latte, a soft, comforting gourmand inspired by warmth and love, and Pavilion d’Or, a serene composition that captures balance and stillness without adhering to a single category.

Throughout the conversation, Pissara returns to one guiding principle: balance. For her, great perfumery isn’t about intensity—it’s about harmony, evolution, and restraint. Dusita’s fragrances don’t demand attention; they reward it.

Listen to the full Skin Anarchy episode to hear how poetry, Thai cultural values, and emotional honesty shape Parfums Dusita—and why the most powerful fragrances are often the quietest ones.

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In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Yannis Alexandrides and Eva Alexandridis, the husband-and-wife team behind 111 Harley St. and 111SKIN, for a candid, science-forward conversation on regenerative aesthetics, protocol-based skincare, and what longevity really looks like when it’s rooted in medicine—not marketing.

111SKIN didn’t start as a beauty brand. It began in the operating room. Dr. Alexandrides shares how his work in facial plastic surgery led him to develop skincare that could support faster healing and stronger outcomes after surgery—when nothing on the market met his clinical standards. What surprised him most wasn’t just improved recovery, but the long-term transformation in skin quality patients experienced once healing was complete. That insight became the blueprint for translating surgical-grade science into daily care.

A central theme of the episode is maintenance. Procedures, Dr. Alexandrides explains, are only as successful as the skin’s baseline health. Eva expands on this philosophy, emphasizing that 111SKIN was never about instant fixes—it was about training skin to behave better over time. Longevity, in their view, is built through consistency, restraint, and respect for biology.

The conversation also dives into the brand’s measured approach to advanced technologies like exosomes—used as targeted protocols rather than trends—and the broader shift in aesthetics toward regeneration over replacement. From deep plane techniques to micrografting, Dr. Alexandrides explains why modern plastic surgery is moving away from excess and toward preservation.

Throughout the episode, one message remains clear: longevity aesthetics aren’t about changing who you are—they’re about supporting skin health so you can look like yourself, for longer.

Listen to the full episode of Skin Anarchy to hear Dr. Yannis Alexandrides and Eva Alexandridis unpack the science behind 111SKIN, regenerative skincare, and the future of evidence-based aesthetic care.

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In this episode of Skin Anarchy, Dr. Ekta sits down with Natasha Denona for a rare, reflective conversation that traces the creative and philosophical roots of one of modern makeup’s most influential brands. Known for palettes that have become industry benchmarks, Natasha opens up about how her work has always been driven less by trends—and more by intention, education, and respect for the user.

Growing up between science and art shaped everything. Natasha’s mother, a chemist in inorganic chemistry, exposed her early to laboratories, precision, and technical thinking. While chemistry itself didn’t immediately click, the discipline behind it did. That structured curiosity later resurfaced in how Natasha approaches formulation, texture, and product architecture—where creativity is always grounded in control.

Before makeup, there was painting, theater, and dance. Natasha shares how color became both emotional language and psychological tool, first explored through art and stage makeup. That foundation explains why her palettes feel cohesive yet expressive—each one designed as a complete story rather than a collection of random shades.

A defining theme of the episode is education. Natasha doesn’t create products to sit on a shelf; she designs tools that teach. Long before “educational beauty” became a marketing buzzword, her launches embedded technique—guiding users through layering, sculpting, and dimension the way professional artists actually work.

Rather than chasing novelty, Natasha deliberately builds for longevity. Palettes like Biba and Camel weren’t designed for a moment—they were designed to last across ages, skin tones, and styles. Inclusivity, she explains, has always been non-negotiable, not performative. Her decision to launch 52 foundation shades wasn’t strategic—it was personal.

Throughout the conversation, one belief remains constant: the product should be the star. Natasha never wanted her image to overshadow the work itself.

Listen to the full episode of Skin Anarchy to hear Natasha Denona reflect on creativity, inclusivity, and why true innovation in beauty comes from intention—not trends.

SHOP NATASHA DENONA

CHAPTERS:

(0:02) - Welcome & Introducing Natasha Denona

(1:14) - Growing Up Around Science, Art, and Photography

(4:43) - Early Relationship With Color, Makeup, and Expression

(6:11) - From Dance & Modeling to Makeup Artistry

(7:26) - Building Iconic Color Stories & Palette Philosophy

(9:05) - Inclusivity as a Core Creative Principle

(13:19) - Creating Complexion Products at Scale

(17:05) - Longevity, Creativity, and Avoiding Trends

(24:08) - Entrepreneurship, Visibility, and Authentic Leadership

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In this episode of Skin Anarchy, Dr. Ekta sits down with Denise Vasi, founder and creative force behind MAED, for a thoughtful conversation about building beauty with intention, patience, and care. Denise’s path into the industry began early—signed to Ford Models and immersed in on-set artistry long before social media shaped beauty culture. Those formative years, paired with memories of her grandmother’s at-home esthetic rituals, planted the seed for a philosophy rooted in preparation, respect, and craft.

Before MAED ever existed, Denise built something rarer than hype: community. Through years of honest storytelling around wellness, motherhood, and clean living, she created a dialogue with women who trusted her voice. That trust shaped MAED’s slow, deliberate evolution. Rather than chasing trends or speed, Denise chose to listen—developing products only when they solved real, lived problems.

At the heart of the brand is a deceptively complex product: the red lip. Denise unpacks why most formulas fail—dryness, poor undertones, and exclusion baked into development—and how MAED set out to fix that. Comfort came first, followed by rigorous testing across skin tones, lip shapes, ages, and backgrounds. Inclusivity, she explains, isn’t a campaign—it’s formulation, design, and function.

Central to MAED’s ethos is one guiding principle: care before color. Lips lack oil glands and cannot repair themselves without real barrier support. MAED’s formulas focus on hydration, resilience, and wear—so color performs because the foundation is healthy.

Beyond product, the conversation explores beauty as ritual and self-expression. The red lip becomes more than pigment—it’s confidence, protection, and presence.

Listen to the full episode to hear Denise Vasi share the philosophy behind MAED, the science of lip health, and why meaningful beauty innovation starts with care—not trends.

SHOP MAED and learn more on their social media!

CHAPTERS:

(0:02) - Introduction & Welcoming Denise Vasi

(0:59) - Early Career: Modeling, Beauty Sets & Formative Influences

(2:16) - Building Community Through Editorial & Made.co

(4:48) - Slow Beauty, Brand Intention & Resisting Trend Cycles

(7:13) - Reimagining the Modern Red Lip

(8:04) - Formulation, Testing & True Inclusivity

(12:16) - What Inclusivity Really Means in Beauty

(16:30) - Lip Health, Barrier Science & Care-First Formulation

(23:10) - Care Before Color & The Cultural Power of a Red Lip

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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Michele Henry, founder and CEO of FACE FOUNDRIÉ, to explore how the facial industry is being quietly—but fundamentally—rewritten. What began as a personal frustration became a scalable solution: professional skincare that’s consistent, accessible, and designed for real life, not just special occasions.

After her third child, Michele found herself stuck between facials that were either overly luxurious, prohibitively expensive, or wildly inconsistent. She wanted results, education, and efficiency—without the intimidation. When that middle ground didn’t exist, she built it. FACE FOUNDRIÉ's facial-bar model challenged long-standing spa norms by focusing exclusively on high-quality facial services delivered quickly, clearly, and consistently.

A central theme of the conversation is accessibility. Michele rejects the idea that skincare should feel exclusive or confusing. Transparent pricing and monthly memberships make frequency possible—and frequency, she explains, is what actually drives results. Prestige may impress, but approachability scales.

Behind the scenes, FACE FOUNDRIÉ's real innovation is operational. Standardized protocols ensure clients receive the same experience across locations, while personalization comes through targeted enhancements layered on top—not improvisation. Technology tracks treatments and progress, reinforcing consistency as a clinical standard.

The episode also tackles a common misconception: that advanced at-home products can replace professional care. Michele makes the case that treatments and products work best together—services like dermaplaning, peels, and extractions create the conditions for skincare to truly perform.

At its core, FACE FOUNDRIÉ is about emotional safety as much as skin health. Clients choose how they want to experience their facial—quiet or educational—in spaces designed to feel welcoming, not intimidating.

Listen to the full episode to hear how Michele Henry is redefining professional skincare—making results-driven facials scalable, sustainable, and built for everyday life.

Learn more about Face Foundarié on their website and social media!

CHAPTERS:

(0:02) - Introduction & Face Foundrie Overview

(0:59) - Michele’s Personal Journey & The Origin Story

(2:16) - Reimagining the Facial Bar Model

(3:23) - Early Trial, Error & Rapid Pivot

(5:26) - Accessibility, Memberships & Breaking Prestige Barriers

(7:16) - Results-Driven Protocols vs Luxury Spa Experiences

(8:23) - Consistency, Personalization & Scalable Systems

(10:26) - Franchising Face Foundrie & National Growth

(13:35) - Technology, AI & The Future of Skin Care Experiences

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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Smitha Rao—biotechnologist, longtime beauty innovator, and founder of Pareva Beauty—for a grounded, science-first conversation on what skin longevity actually means. Part of the Lessons in Longevity series, this episode challenges the tired idea of “anti-aging” and reframes skincare as long-term biological support rather than surface-level correction.

With nearly two decades in biotech and beauty, Smitha brings a rare perspective shaped by molecule development, patents licensed across major brands, and leadership roles behind more than 200 products. That experience revealed a growing disconnect: while consumers want clarity and real science, the industry often defaults to hype, fear-based claims, and trend chasing. Pareva Beauty was born as a response—built on transparency, rigor, and the belief that longevity is about extending skin function and resilience, not reversing time.

At the center of the discussion is Molecur 3™, Pareva’s proprietary, plant-based technology inspired by the Hallmarks of Aging. Smitha explains how targeting inflammation, cellular stress, and age-related decline—rather than isolated “anti-aging” claims—creates a more realistic and sustainable path for skin health. The conversation also dives into plant-derived exosomal signaling, why it differs from human-derived systems, and how it offers a safer, scalable approach for topical longevity skincare.

Together, Dr. Ekta and Smitha unpack why fewer, better-designed products outperform complex routines, why transparency matters more than vague “clean” labels, and how longevity skincare must earn trust through data—not promises.

Listen to the full episode to hear how Smitha Rao is helping redefine the future of skincare—where science, honesty, and long-term skin health come first.

Shop Parëva Beauty and use code SA20 for 20% through 3/17.

CHAPTERS:

(0:02) - Introduction, Lessons in Longevity & Smitha Rao

(1:21) - From Biotech to Beauty Innovation

(2:50) - Why Pareva Was Created & The Longevity Gap

(3:33) - Defining Skin Longevity & Extending Your Prime

(5:38) - Rejecting Anti-Aging & Reframing Aging Quality

(8:51) - Molecure 3™: Hallmarks of Aging Inspiration

(10:27) - Plant Stem Cells, NAD⁺ & Exosome Signaling

(14:00) - Exosomes Explained: Plant vs Human-Derived

(22:51) - Simplifying Skincare: Fewer Steps, Better Results

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In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Dr. Alexes Hazen—board-certified plastic surgeon, microsurgery specialist, and founder of Zen Essentials—for a thoughtful conversation on skin health, ethical aesthetics, and why real results can never be separated from whole-body well-being. With a background that spans public health, global medicine, and some of the most technically demanding surgical training, Dr. Hazen brings a rare depth to how she thinks about beauty, healing, and care.

Her path to medicine was anything but linear. From working with the New York City Department of Health during the AIDS crisis to serving in the Peace Corps in Honduras, Dr. Hazen learned early that medicine isn’t just technical—it’s human. Those experiences shaped a philosophy she carries into every aspect of her work today: outcomes are influenced as much by mental health, sleep, nutrition, and support systems as they are by surgical skill.

Throughout the conversation, Dr. Hazen challenges the surface-level thinking that dominates skincare culture. Skin, she reminds us, is an organ—and it reflects what’s happening internally. No product can compensate for chronic stress, dehydration, or exhaustion. When those fundamentals are addressed, skincare finally has the space to work as it should.

She also speaks candidly about ethics in aesthetic medicine—why board certification matters, why saying “no” is sometimes the most responsible choice, and how listening to patients should always come before selling solutions.

That same restraint and intention led to the creation of Zen Essentials, born from Dr. Hazen’s own struggles with severe skin sensitivities. Designed to be effective yet calming, the line reflects her belief that skincare should support the body—not fight it.

Listen to the full episode to hear Dr. Alexes Hazen unpack holistic healing, ethical aesthetics, and why real skin health starts with caring for the whole person.

SHOP Zen Essentials and learn more on social media!

CHAPTERS:

(0:02) - Introduction & Guest Welcome

(0:46) - A Nonlinear Path Into Medicine

(1:26) - Public Health, AIDS Education & the Peace Corps

(2:46) - Falling in Love With Surgery & Plastic Surgery Training

(3:01) - Early Burn Injury, Scars & Coming Full Circle

(4:12) - Why Holistic Care Matters in Surgical Outcomes

(8:40) - Skin as a Reflection of Whole-Body Health

(11:22) - Ethics, Training & Responsibility in Aesthetic Surgery

(26:21) - The Origins of Zen Essentials & Sensitive Skin Science

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In this special episode of Skin Anarchy, Dr. Ekta Yadav sits down with supermodel, actress, podcaster, and YSE Beauty founder Molly Sims for an intimate conversation on how beauty evolves, how confidence is built, and how skincare becomes smarter with age. Known for her iconic presence and unfiltered approach on Lipstick on the Rim, Molly opens up about the real experiences that shaped her philosophy — from hormonal acne and melasma to rediscovering balance after years of harsh actives.

Molly reflects on her earliest beauty memories, watching her mother turn daily routines into rituals that embodied strength and joy. That foundation, combined with her global modeling career, became its own education: effortless French skincare, British edge, Italian sensuality, and a universal truth — consistency beats extremes.

Her journey to creating YSE Beauty began after her skin hit what she calls a “benefit plateau,” when aggressive ingredients stopped delivering results. She shares how shifting toward cushion actives, barrier support, and clinical but sensorial formulations transformed her skin and inspired a brand built on wisdom, simplicity, and results that feel good.

For Molly, beauty isn’t about correction or perfection — it’s about alignment. It’s the confidence that comes from choosing what serves you, whether that’s a glow-inducing exfoliating pad, a subtle procedure, or simply giving your skin room to breathe.

Listen to the full episode to hear Molly Sims discuss aging with intention, building YSE Beauty from the ground up, and why true luxury isn’t the price tag — it’s how you feel in your own skin.

SHOP YSE Beauty and learn more on their social media!

CHAPTERS:

(0:03) - Introduction & Guest Welcome

(1:07) - Early Beauty Memories & “It Girl” Origins

(2:44) - Influences From Travel, Fashion & Global Beauty Culture

(4:53) - Shifting Aesthetic Trends: From Harsh Treatments to Maintenance

(6:59) - Social Media, Filler Culture & Confidence

(9:46) - Personal Journeys With Procedures, Aging & Empowerment

(12:11) - Why Wise Beauty Was Created

(17:05) - Actives, Cushioning Ingredients & the Skin Plateau

(21:52) - Luxury vs. Efficacy, Accessibility & Building a Smarter Beauty Brand

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In this powerful episode of Skin Anarchy, Dr. Ekta Yadav sits down with one of the most influential minds in modern aesthetics, Dr. Steven Dayan — facial plastic surgeon, New York Times bestselling author, educator, and founder of XOMD Skincare. Together, they explore the deeper layers of beauty: the biology, the psychology, and the emotional resonance that shape how we see ourselves and others.

Dr. Dayan reflects on his unconventional path from sculptor to surgeon, sharing how art, science, and human emotion converged to form his philosophy of aesthetics. Beauty, he explains, is rooted in evolution — a subconscious signal of wellness and vitality — but attraction is the true driver of human connection. Confidence, authenticity, posture, expression, and energy all play into how attractive we feel, and therefore how we’re perceived.

Throughout the conversation, Dr. Dayan breaks down the subtle, powerful ways aesthetic treatments can influence mood and behavior. Small changes can boost approachability and positivity — while overtreatment can create emotional dissonance and mistrust. He offers a candid look at how social media has reshaped our aesthetic bias, urging both providers and consumers to recalibrate toward natural proportions and personal identity.

Dr. Dayan also gives listeners an inside look at XOMD Skincare, his newest innovation with Dr. Sabrina Fabi, built around the neurochemical link between skin health and confidence.

Listen to the full episode to learn how Dr. Dayan is redefining beauty through the lens of neuroscience, culture, and human connection — and why confidence may be the most transformative aesthetic treatment of all.

SHOP XOMD and use code SApod for 10% off!

CHAPTERS:

(0:02) - Introduction & Guest Welcome

(1:12) - Early Life, Medicine & the Path to Surgery

(3:01) - Writing, Creativity & the Philosophy of Beauty

(6:05) - Defining Beauty: Neuroscience, Evolution & Emotion

(11:00) - Beauty vs. Attraction & the Role of Confidence

(14:50) - Social Media, Trends & Aesthetic Bias

(18:40) - Authenticity, Expression & First Impressions

(21:03) - Rethinking Training, Safety & Best Practices

(24:00) - Global Beauty Standards & Cultural Perspectives

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