The deficiency of progesterone creates huge problems in women's health.  Even though Dr. Katharine Dalton championed the use of progesterone and described the deficiency symptoms in the 1950, way too many women suffer still with PMS, PCOS,infertility, PMDD, mental disorders,fibroid, heavy bleeding, hysterectomies, ovarian cysts,  The lack of progesterone is solidly behind all these issues.