The Dr. London Podcast

In today's video, Dr. Jeremy London, MD, a board-certified cardiovascular surgeon, shares his thoughts on statins, cholesterol, and heart attacks.

He explains why cholesterol is essential to the body, why ApoB is the main culprit, and how medications can help reduce risk.

He also addresses statin side effects, statins vs. dementia, and other medications that are widely available.

By the end of this video, you have a much better understanding of cholesterol, ApoB, statins, and heart disease.

Make sure to check out my article "How to Lower Your ApoB (Apolipoprotein B)": https://drjeremylondon.com/articles/how-to-lower-your-apob-apolipoprotein-b

Thank you to our sponsor:

Function Health: Where my family and I test our ApoB and 160+ lab tests for less than $1/day at: https://functionhealth.com/london

Jeremy London, MD:

My Newsletter: https://www.drjeremylondon.com/newsletter

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomization analysis: https://pmc.ncbi.nlm.nih.gov/articles/PMC7089422/

Association of Triglyceride-Lowering LPL Variants and LDL-C–Lowering LDLR Variants With Risk of Coronary Heart Disease: https://jamanetwork.com/journals/jama/fullarticle/2722770?

A meta-analysis of 25 randomized trials (46,836 patients) found no difference between statin and placebo in cognitive adverse events or cognitive test scores: https://link.springer.com/article/10.1007/s11606-014-3115-3

PROSPER randomized 5,804 adults aged 70–82 to pravastatin or placebo for ~3.5 years, with cognition tested at six points during the trial. Cognition declined at the same rate in both groups — and this is the age group that should be most sensitive to any harm: https://link.springer.com/article/10.1007/s00415-009-5271-7

EBBINGHAUS (evolocumab) and alirocumab cognitive studies found no cognitive decline even when LDL was driven very low. If lowering cholesterol starved the brain, we’d see it there: https://www.nejm.org/doi/10.1056/NEJMoa1701131

STAREE, just published in NEJM, randomized adults 70 and older with no history of cardiovascular disease, diabetes, or dementia to atorvastatin 40 mg or placebo. Over a median of 5.9 years, major cardiovascular events fell by 30% with atorvastatin. Death, dementia, or persistent disability was not worse on the statin: https://www.nejm.org/doi/10.1056/NEJMoa2607314

0:00 My Take on Cholesterol and Statins

0:41 ApoB: Why Cholesterol Particle Count Matters

2:07 How Metabolic Health Affects Your Arteries

3:48 Lifestyle Changes and When to Consider Medication

7:14 Statins: Benefits, Side Effects, and Alternatives

10:04 Cholesterol, Brain Health, and Your Prevention Plan

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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How does heart health relate to dementia? More than you might think.

In this episode, Dr. Jeremy London explores the connection between cardiovascular and brain health, explains the major types of dementia, and discusses risk factors such as age, genetics, high blood pressure, smoking, and cholesterol.

He also breaks down how exercise, nutrition, hearing and vision care, and social connection may help reduce dementia risk—with practical steps you can start taking today to support your heart and brain.

Thank you to our sponsors:

Rho Nutrition: Get 25% off the most bioavailable supplements on the market by heading to ⁠https://rhonutrition.com/london⁠ (Code: LONDON)

Function Health: Get the same 160+ lab tests that my family and I get for less than $1/day at: https://functionhealth.com/london

Jeremy London, MD:

My Newsletter: https://www.drjeremylondon.com/newsletter

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00 Understanding Dementia and Its Impact on Families

02:58 The Main Types of Dementia

03:38 Age, Genetics, and Alzheimer’s Risk

06:54 Modifiable Risk Factors: The Heart–Brain Connection

08:06 High Blood Pressure and Brain Health

10:07 Smoking, Blood Vessels, and Stroke Risk

11:47 ApoB, Cholesterol, and Statins

15:13 Blood Sugar, Visceral Fat, and Insulin Resistance

16:38 Education and Lifelong Brain Health

17:09 Hearing Loss and Vision Loss

18:08 Head Injuries and Dementia Risk

18:48 Social Connection and Depression

19:28 Alcohol, Air Pollution, and Toxins

20:58 Practical Steps to Support Your Brain

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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In today's episode, you will learn, step by step, how to get closer to the life you actually want.

Dr. Jeremy London sits down with Sahil Bloom, an investor, entrepreneur, and author of the New Times bestselling book, The 5 Types of Wealth: A Transformative Guide to Design Your Dream Life.

Sahil shares how we went from financial success and misery to building a life we wake up excited to live.

He argues that we aren't playing the wrong game, but we're playing the game wrong.

From this conversation, you will learn how to build a wealthy life beyond financial success, define what success means to you, and start taking action today.

Many times we trade today for a distant tomorrow.

Use today to start living the life you want.

LMNT: Get a free sample pack of LMNT's most popular flavors with any purchase at ⁠https://www.drinklmnt.com/london⁠⁠

Rho Nutrition: Get 20% off the most bioavailable supplements on the market by heading to ⁠⁠https://rhonutrition.com/london⁠⁠ (Code: LONDON)

Function Health: Get the same 160+ lab tests that my family and I get for less than $1/day at: ⁠https://functionhealth.com/london⁠

Sahil Bloom:

Instagram: ⁠https://www.instagram.com/sahilbloom/⁠

X: ⁠https://x.com/SahilBloom⁠

Sahil's Newsletter: ⁠https://www.sahilbloom.com/newsletter⁠

YouTube: ⁠https://www.youtube.com/@Sahil_Bloom⁠

5 Types of Wealth: ⁠https://a.co/d/0esxuWZd⁠

Jeremy London, MD:

My Newsletter: ⁠https://www.drjeremylondon.com/newsletter⁠

Instagram: ⁠https://www.instagram.com/drjeremylondon/ ⁠

TikTok: ⁠https://www.tiktok.com/@drjeremylondon⁠

Facebook: ⁠https://www.facebook.com/drjeremylondonmd ⁠

Timestamps:

00:00 — Why Sahil Stopped His Marathon at Mile 21

03:37 — How Failure Breeds Future Success

10:51 — External vs. Internal Scoreboards

13:24 — The “15 More Times” Wake-Up Call

20:37 — Small Course Corrections That Change Your Life

31:16 — The Average Tuesday Theory

37:32 — Stillness, The Power of "No", and Protecting Your Energy

45:12 — Stop Consuming Information and Start Taking Action

55:01 — Why Imposter Syndrome Is a Sign of Growth

1:01:15 — The Five Types of Wealth and a Better Definition of Success

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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In today's podcast episode, Dr. Jeremy London, MD, a board-certified cardiovascular surgeon, shares the 5 habits that helped him become a heart surgeon. These habits can be applied in your life regardless of whether you are in medicine or not.

My Newsletter:

https://www.drjeremylondon.com/newsletter

Thank you to our sponsors:

LMNT: Get a free sample pack of LMNT's most popular flavors with any purchase at ⁠https://www.drinklmnt.com/london

Rho Nutrition: Get 20% off the most bioavailable supplements on the market by heading to ⁠https://rhonutrition.com/london⁠ (Code: LONDON)

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00:00 5 habits that help me become a heart surgeon

00:00:46 Habit 1: Wake Up Early

00:03:49 Habit 2: Read

00:08:23 Habit 3: Just Show Up

00:10:50 Habit 4: Move Your Body Daily

00:15:25 Habit 5: Welcome Challenge into Your Life

00:18:42 Bonus: Be Persistent

00:20:53 Thank you for listening!

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In today’s podcast episode, Dr. Jeremy London, a board-certified cardiovascular surgeon, answers the questions you sent in. Ranging from cholesterol, blood pressure, and aortic aneurysm to a heart surgeon's mindset and perspective. Hope you enjoy!

My Newsletter

https://www.drjeremylondon.com/newsletter

Thank you to our sponsors

LMNT: Get a free sample pack of LMNT's most popular flavors with any purchase at https://www.drinklmnt.com/london

Rho Nutrition: Get 25% off the most bioavailable supplements on the market by heading to https://rhonutrition.com/london (Code: LONDON)

Rorra: The highest-quality filtered water pitcher is now available. If you want cold, clean water you and your family can trust go to https://www.rorra.com/london to save 25% on your water filter.

My Social Media

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00:00 Q&A Podcast

00:00:49 What are the most effective ways to reduce your risk of heart disease?

00:07:34 Why is cholesterol so important, and at the same time, we want to lower it?

00:11:32 If you're diagnosed with high Lp(a), what does this mean, and what should you do next?

00:15:45 What are the most important ingredients for a healthy diet

00:20:11 Advice for those interested in a career in medicine

00:23:52 Who is on the heart surgery team, and what role does everyone have?

00:29:19 What is an aortic aneurysm how is it diagnosed and treated?

00:40:40 What's one area you've changed your mind on in medicine

00:46:30 What habits are responsible for your success and failures

00:50:42 Why did you make the decision to stop drinking alcohol?

00:54:49 What's the best piece of advice you've ever received?

00:57:18 Thank you for listening!

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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I'm Dr. Jeremy London, a board-certified cardiovascular surgeon in practice for over 25 years. In this episode I break down five landmark cardiovascular studies, the foundational research that did the heavy lifting to shape how we treat heart disease today.

But this isn't just a history lesson. I walk through each study the same way a physician does: how the study was designed, what it got right, what it got wrong, and whether it held up over time. That framework is the real takeaway, because in an age of overwhelming health information, knowing how to evaluate a study is more valuable than memorizing any single result.

We go from Framingham in 1948, which invented the very idea of a "risk factor," all the way to SPRINT in 2015, which changed the blood pressure number we all aim for. Along the way you'll see exactly how these studies stack on top of each other to answer the next question: Do risk factors exist? Which ones matter most? Is one of them actually causal? And how hard should we push when we treat them?

Medical science isn't stone tablets. It's guidance, and it should be pressure-tested constantly. Strong beliefs, loosely held.

Thank you to our sponsors:

LMNT: Get a free sample pack of eight flavors with any purchase at: https://drinkLMNT.com/london

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CHAPTERS

0:00 – What this episode covers & why foundational studies matter

2:10 – Study #1: The Framingham Heart Study (1948)

4:15 – What Framingham got right: risk factors compound

5:05 – Where Framingham fell short, and how it holds up today

6:05 – Study #2: The 2013 smoking study (200,000 smokers)

7:15 – Quitting before 40 drops your risk by nearly 90%

7:35 – The study's flaws, and why the numbers still hold

9:20 – Sponsor: LMNT

10:45 – Study #3: INTERHEART, 52 countries, 9 risk factors

11:20 – Ranking the risk factors: cholesterol, smoking, stress

12:15 – The weakness of a retrospective study

13:00 – Study #4: Mendelian randomization: is cholesterol causal?

13:40 – Why the "ideal" cholesterol study can't ethically be run

14:20 – Nature's controls: the genetic lottery on both ends

15:55 – Lower is better, earlier is better (the sun exposure analogy)

17:30 – Where it holds up today: apolipoprotein B

18:15 – Sponsor: Function Health

19:40 – Study #5: The SPRINT trial (2015), how low should BP go?

20:35 – Why they stopped the trial early

21:20 – The catch: how blood pressure was actually measured

22:20 – Why 120 became the standard

23:10 – Putting all five together: the decision-making chain

24:20 – How to evaluate any medical study yourself

25:45 – "Strong beliefs, loosely held"

26:15 – Closing thoughts

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In today's episode, Dr. Jeremy London, board-certified cardiovascular surgeon, breaks down the most common cholesterol question he gets: how do you actually lower your ApoB? He explains why ApoB predicts cardiovascular risk better than LDL-C, why insulin sensitivity is the through line connecting sugar, saturated fat, fiber, muscle, and body weight, and what to do when you've done everything right and your numbers still won't budge.

Thank you to our sponsors:

LMNT: Replace what you actually sweat out - FREE 8-flavor sample pack with any purchase → https://www.drinklmnt.com/london

Function Health: 160+ labs, 5x your standard panel, for less than a dollar a day (Use code LONDON25 as your access code and LONDON25 as your gift code at checkout to unlock your $25 credit.) → https://www.functionhealth.com/london

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In today's episode, Dr. Jeremy London, board-certified cardiovascular surgeon, breaks down everything you need to know about stroke. He explains the different types of stroke, the warning signs your body gives you before one happens, who's most at risk, and the critical steps you can take right now to protect yourself and the people you love.

My Newsletter: https://www.drjeremylondon.com/newsletter

Thank you to our sponsors:

LMNT: https://www.drinklmnt.com/london

Rho Nutrition: https://www.rhonutrition.com/london

Get access to every episode before YouTube by subscribing for free on Spotify - https://spoti.fi/3FU0S6O or Apple Podcasts - https://apple.co/3DJvyav

My Social Media:

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00:00 What Is a Stroke?

00:03:00 Ischemic vs. Hemorrhagic Stroke

00:07:00 Warning Signs Everyone Should Recognize

00:11:00 Who's Really at Risk?

00:15:00 The Link Between Heart Disease and Stroke

00:20:00 What You Can Control Starting Today

00:25:00 When Every Minute Counts

00:30:00 Thank You For Listening!

** The information in this video is not intended nor implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/health professional **

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In today's episode, Dr. Jeremy London, board-certified cardiovascular surgeon, uncovers how healthy people are still having heart attacks. He explains how LDL-C isn't the only blood test that predicts heart disease, the genetic risk factors everyone should know about, and which factors you can control to prevent a heart attack in the future.

https://www.drjeremylondon.com/newsletter

Thank you to our sponsors

Function Health: https://www.functionhealth.com/london

Rorra: https://www.rorra.com/london

My Social Media

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00:00 How "Healthy" People Still Have Heart Attacks

00:01:20 Two Patient Scenarios. One Problem

00:05:20 LDL-C vs. ApoB

00:07:40 Lp(a): The Hidden Genetic Risk Factor

00:09:28 Normal Does NOT Equal Optimal

00:10:00 What Happens Inside Your Arteries?

00:12:41 The INTERHEART Study: Preventable Risk Factors for Heart Attacks

00:17:40 Genetics: Your Heart is Your Heart

00:21:53 Thank You For Listening!

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In today's podcast episode, Dr. Jeremy London, board-certified cardiovascular surgeon, unpacks 3 ways alcohol affects your heart. He breaks down how alcohol raises blood pressure, increases the risk of arrhythmias like atrial fibrillation, and how heavy alcohol consumption can lead to heart failure.

My Newsletter

https://www.drjeremylondon.com/newsletter

Thank you to our sponsors

Rho Nutrition: https://www.rhonutrition.com/london

LMNT: https://www.drinklmnt.com/london

My Social Media

Instagram: https://www.instagram.com/drjeremylondon/

TikTok: https://www.tiktok.com/@drjeremylondon

Facebook: https://www.facebook.com/drjeremylondonmd

Timestamps:

00:00:00 How Drinking Alcohol Affects Your Heart Health

00:02:29 Alcohol Metabolism & The Dangers of Acetaldehyde on Your Heart

00:05:51 High Blood Pressure, AFib, and Heart Failure

00:12:51 Is Low to Moderate Alcohol Consumption Safe? Red Wine?

00:21:35 The Good News: Reducing/Quitting Alcohol Makes A Difference

00:24:00 No Safe Amount of Alcohol Consumption

00:26:51 My Challenge to You

00:27:48 Thank you for listening!

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