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In this wide-ranging conversation, Preston and Seb unpack the biology of aging and the emerging science behind longevity. They take about epigenetics, sirtuins, Yamanaka factors, and how AI may accelerate regenerative medicine, offering a glimpse into the future of human health.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 - Intro
00:05:04 - Why Aging Might Be a Disease—and What That Changes Scientifically
00:07:05 - What Epigenetics Is and How It Affects Cellular Aging
00:24:37 - How Yamanaka Factors Can Reset Cells and Potentially Reverse Aging
00:35:43 - The Role of Fasting, Cold, and Heat in Triggering Repair Pathways
00:30:22 - What NMN and Sirtuins Do in the Body and Their Role in Longevity
00:42:26 - How AI Could Simplify and Accelerate Breakthroughs in Aging Science
00:48:48 - The Philosophical Trade-Offs of Living Longer Versus Living Better
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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On today’s episode, Kyle Grieve discusses how timeless philosophical ideas can deepen our understanding of investing and life. He explores lessons from thinkers such as Spinoza, Nietzsche, Hume, and Pascal to reveal how concepts like persistence, skepticism, and luck shape decision-making. Kyle also connects these ideas to modern investing by drawing on insights from Buffett, Voltaire, and Bruce Lee, showing how adaptability, emotional control, and inner reflection lead to better outcomes.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 - Intro
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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In this episode, Stig Brodersen speaks with Tobias Carlisle — founder and managing director of Acquirers Funds — about Warren Buffett’s timeless approach to risk. Drawing from Tobias’s new book, Soldier of Fortune, they explore how ancient wisdom, especially from The Art of War, reveals the deeper logic behind Buffett’s biggest and most misunderstood investing decisions.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 - Intro
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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Mark Suman, co-founder of Maple AI and OpenSecret, shares his insights on how to build cutting-edge AI without sacrificing user privacy.
From secure enclaves and attestation to real-world use cases in law and finance, Mark outlines the technical and ethical foundations of private AI, and why efficient inference, not just open models, is the next big frontier.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 - Intro
00:01:57 - How Mark’s Time at Apple Shaped His Vision for Secure, User-First AI
00:06:06 - Why Verifiable AI Matters for Protecting User Data
00:07:38 - The Privacy Threats of Centralized AI Models
00:15:26 - What Maple AI Does That Other AI Tools Don’t—End-to-End Encrypted, Verifiable Privacy
00:17:30 - The Threat Models Maple Addresses and How Enclaves + Attestation Work
00:19:51 - Why Inference Speed and Efficiency—Not Open Weights—Are the New AI Battleground
00:24:05 - Where Decentralized AI Fits Into Today’s Landscape
00:25:12 - A Step-by-Step Guide to Getting Started with Maple
00:29:13 - How Users Change Behavior When They Trust the AI System
00:32:42 - The Risks and Critiques of TEEs—and How Maple Answers Them
00:37:35 - Which Professions Benefit Most from Private AI
00:45:27 - Mark’s Vision for Verifiable, Private AI Over the Next Decade
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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William Green chats with Jim Grant, famed editor of Grant’s Interest Rate Observer. Here, Jim warns that a major market top is forming as exuberance inflates stocks, Bitcoin, and gold. He says it echoes past bubbles and urges extreme caution.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 Intro
00:10:40 Why Jim Grant is fiercely skeptical about Bitcoin.
00:19:25 Why you should be wary of all the hype about Private Equity.
00:35:50 Why Jim expects the AI boom to end in “a panic & a crash.”
00:44:13 Why even the shrewdest speculators never know when it’s time to sell.
00:49:50 What the Federal Reserve is likely to do with interest rates.
00:57:53 Why the dollar seems poised to continue losing value.
01:04:28 Why inflation will persist, fueled by perennial flaws in human nature.
01:09:50 Why Jim loves gold but is starting to worry about its meteoric rise.
01:19:01 Why he owns some bonds, despite his grim prognosis for this asset class.
01:23:39 How bull markets attract sleazy salesmen & bear markets clear them away.
01:25:56 What inspired him to write a new book about two 18th-century heroes.
01:59:34 How studying history helps him appreciate some benefits of modern life.
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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In this episode, Clay shares the most important investing lessons he wishes he could tell his 18-year-old self. Drawing from more than a decade of experience, he distills twelve timeless principles that every investor should know, from the value of patience and independent thinking to understanding where long-term returns come from. Whether you’re just starting out or refining your approach, this episode offers practical insights to help you build lasting wealth and confidence as an investor.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 Intro
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Joe, Jeff, HODL, and Preston break down Q3 2025’s economic trends, market cycles, and BTC's performance. They dive into gold’s rise, AI's impact on capitalism, and the U.S.’s shifting global strategy, with bold Bitcoin price forecasts for 2026.
IN THIS EPISODE YOU’LL LEARN:
00:01:13 Why market sentiment feels bearish despite a 67% BTC gain
00:07:58 How the S&P 500 vs. gold ratio signals a macroeconomic inflection point
00:10:39 Why Jeff Ross sees gold outperforming stocks into the 2030s
00:28:12 The stalled progress of the Strategic Bitcoin Reserve legislation
00:35:07 Central banks’ gold stockpiling and its effect on markets
00:37:09 How upcoming Fed policy could shape future rate cuts
00:46:58 The complex future of capitalism in an AI-driven economy
00:50:45 Insights into America’s $6-7 trillion infrastructure buildout
00:59:40 Why BTC treasury firms are underperforming while miners surge
01:05:35 2026 BTC price predictions and a playful nod to Peter Schiff
Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.
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On today’s episode, Kyle Grieve discusses ten investing principles from legends like Warren Buffett, Peter Lynch, and John Neff. Each lesson reveals how these masters built lasting wealth through timeless thinking. It’s a crash course in investing smarter, thinking clearer, and playing the long game.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 Intro
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In this episode, Clay explores the extraordinary rise of Tesla and how Elon Musk transformed it from a niche electric car startup into one of the most valuable companies in the world. Since its IPO in 2010, Tesla has compounded at an incredible 47% per year and completely reshaped the automotive industry through software-driven vehicles, vertical integration, and their global charging network.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 Intro
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Preston and Jevi unpack the double-edged sword of modern technology. They examine how social media, AI, EMFs, and LED lights impact our well-being, and offer real-world privacy solutions like Graphene OS and open-source photo apps.
From sleep disruption to self-sovereignty, they advocate for mindful tech use and explore how AI can act as a “second brain” while respecting user privacy.
IN THIS EPISODE YOU’LL LEARN:
00:00:00 Intro
00:03:50 How social media algorithms can both help and harm your mental well-being
00:07:56 The benefits of switching to privacy-respecting platforms like Nostr
00:09:32 What self-sovereignty in digital spaces really means
00:12:14 Why being intentional about digital content consumption is crucial
00:12:55 How to use AI and LLMs responsibly as personal information tools
00:18:38 Real-life alternatives to Big Tech’s data-hungry photo storage services
00:29:10 The hidden risks of EMF exposure from common devices
00:38:49 Why LED lights and blue light can disrupt your sleep
00:42:35 Practical tools to mitigate tech’s effects, like Daylight Tablets and color filters
00:47:12 How to strike a balance between tech’s convenience and its consequences
00:51:36 Outro
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