A healthy 54-year-old mom goes from beach-week brain fog to 103° fevers, crushing fatigue, chest spasms, and organ dysfunction in a matter of days—ping-ponging through a possible UTI, pancreatitis, and pneumonia diagnosis before landing in the sepsis ward with ARDS and sky-high liver enzymes. With cultures negative and answers scarce, an infectious disease “detective” adds doxycycline—and Carrie’s hunch, sparked by local news headlines, finally cracks the case of the mystery illness that almost killed her.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

Two friends, Sasha and Nella, join us to unravel how years of “it’s all in your head” dismissal, mounting pain, and endless referrals finally led them to a rare-yet-underdiagnosed culprit. In a story powered by patient research and friendship, Sasha’s viral TikTok becomes Nella’s lifeline, guiding her to a diagnosis, a pioneering costal margin reconstruction surgery in West Virginia, and even a successful fight to get Canada’s OHIP to fund out-of-country care.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

Get ready for double the mystery and double the disbelief. In this episode of The Medical Detectives, identical twins Claire and Suzanne share a lifetime of parallel symptoms, and a decade of debilitating GI problems, that left doctors baffled. From years of being told it was “just IBS” to being dismissed as psychosomatic, these sisters prove what happens when intuition, persistence, and a little “twintuition” collide with medical bias.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

When a healthy, outdoorsy vegan develops burning foot pain after a bout of COVID-19, months of sleepless nights, dead-end appointments, and dismissive doctors follow, until Michelle turns herself into a one-woman research lab. In this episode, Anna and Erin unpack her rare diagnosis and how DIY experiments led to answers.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

When 16-year-old Ivan suddenly lost weight, slept through class, and found that eating hurt, doctors called it “disordered eating”—but Dana’s gut said something else. In this gripping, hopeful conversation, a midnight ER dash, blue lips, and a blaring heart monitor lead to the scan that changes everything. You’ll hear how bias can derail care, how distension pain hides in plain sight, and how one family kept pushing until the right tests—and treatment—brought Ivan back.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

In this powerful episode of Medical Detectives, Elizabeth traces an intergenerational medical mystery. This story starts not with our guest, but with her mother, whose lifelong health concerns gave a clue into Elizabeth's own medical mystery. After years of labels (hypothyroidism, PCOS, “degenerative disc disease,” postpartum depression) and a crucial clue everyone missed, one determined rheumatologist finally connected the dots to a rare genetic bone-mineralization disorder. Elizabeth describes the relief of a name for her suffering, the whiplash of treatments that helped until insurance pulled them, and the uphill fight to access the only disease-modifying therapy.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

A healthy 33-year-old runner and new mom develops sudden, stabbing chest pain after childbirth that’s dismissed for years as reflux. What follows is a 12-year odyssey of sporadic esophageal spasms, misreads, and missed chances, culminating in dangerous malnutrition before a textbook barium swallow finally confirms the mystery diagnosis.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

Zoe’s story is a masterclass in “collect the dots so you can connect the dots.” After years of migraines, numbness, GI chaos, and escalating sciatica, her symptoms were brushed off as “stocking-and-glove neuropathy,” weight, or stress. Her symptoms crescendoed to saddle anesthesia, leg tremors, and urinary trouble, which were the red flags doctors used to finally make an emergency diagnosis, and just in time because Zoe was only 24 hours away from being completely paralyzed.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

Introducing our new series, Sleuth Stories, spotlighting the medical investigators who solved some of the biggest medical mysteries in history. In this premiere, we follow Dr. Alice Stewart, the physician-epidemiologist who studied a rise in childhood cancer, and eventually used her findings to change the world.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***

This is a re release of a past episode, but we will be back next week with brand new content!

On this episode of The Medical Detectives, we sit down with the incredible Chan, known to many as @chanplante on TikTok, to hear her harrowing medical journey from an invisible illness to a visible one. Chan takes us through the baffling medical experiences that followed her COVID-19 diagnosis—unexplained strokes, eye pain, and a frustrating maze of misdiagnoses that ultimately led to her losing vision in one eye.

In this raw and deeply personal conversation, Chan opens up about the emotional toll of seeking answers in a healthcare system that often dismisses young women, the frustration of living with an undiagnosed chronic illness, and the resilience it takes to advocate for yourself when doctors tell you, "It's just anxiety."

If you've ever felt unheard in a medical setting, struggled with a chronic illness, or simply want to hear an inspiring story of strength, this episode is for you.

Join the conversation! Have a medical mystery or story of your own? Send it to [email protected].

***The information provided on the medical detectives is for informational and entertainment purposes only and should not be considered medical advice. While we may feature licensed medical professionals, including doctors, we are not your personal doctors and no doctor patient relationship is established by listening to this podcast or interacting with our content.

All discussions are general in nature and may not apply to your specific health situation. Always seek the advice of a qualified healthcare professional before making any medical decisions or taking any action based on the content of this podcast. Never disregard professional medical advice or delay seeking treatment because of something you have heard on this show

If you are experiencing a medical emergency, please contact emergency services immediately or consult a qualified healthcare pro***