The Peter Attia Drive

In this episode, Damon Hill, 1996 Formula 1 World Champion, opens up about his personal struggles with depression, feelings of inadequacy, loss of identity, and his ultimate path to healing following his remarkable racing career. Damon's life was given a tragic jolt at 15 years of age when his father and legendary F1 driver Graham Hill died suddenly—the common string that ties together so much of his life and has forged so much of who he is to this day. We discuss Damon's unique and remarkable racing career including his legendary battles with Michael Schumacher as well as Damon's firsthand account of what happened that tragic day on May 1st, 1994, when his teammate, Ayrton Senna, died at Imola. But this is not just about racing; rather it's a human story that's cloaked in a racing one.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/damonhill/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Today's episode of The Qualys is from podcast #03 – Ron Krauss, M.D.: a deep dive into heart disease.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

In this episode, Dr. Iñigo San Millán, Assistant Professor at the University of Colorado School of Medicine, explains the crucial role of mitochondrial function in everything from metabolic health to elite exercise performance. Iñigo provides a masterclass into the many different energy system pathways, the various fuel sources (including the misunderstood lactate), the six zones of exercise training, and the parameters he uses to measure metabolic health. Additionally, he highlights the power of zone 2 training in its ability to act as a powerful diagnostic tool, and perhaps more importantly as a treatment for mitochondrial and metabolic dysfunction.

We discuss:

• Iñigo's background in sports and decision to focus on education [7:15];

• Explaining the various energy systems and fuels used during exercise [14:45];

• Iñigo qualifies energy systems into six training zones [26:00];

• Lactate is an important fuel source [33:00];

• Zone 2 training—physiologic characteristics, fuel sources, lactate, and the transition into zone 3 [40:30];

• Using blood lactate levels (and zone-2 threshold) to assess mitochondrial function [47:00];

• Accessing mitochondrial function by looking at one's ability to utilize fat as fuel (with an RQ test) [55:00];

• Athletes vs. metabolically ill patients—mitochondria, fat oxidation, muscle glycogen capacity, "fat droplets", and more [1:00:00];

• Physiologic characteristics of zone 3, zone 4, and the lactate threshold [1:20:00];

• Fueling exercise—dietary implications on glycolytic function [1:30:30];

• Relationship between exercise and insulin sensitivity (and what we can learn from studying patients with type 1 diabetes) [1:46:30];

• Metformin's impact on mitochondrial function, lactate production, and how this affects the benefits of exercise [2:04:15];

• Raising awareness for risk of "double diabetes" [2:15:00];

• How to dose zone 2 training, and balancing exercise with nutrition [2:18:00];

• Proposed explanation of the Warburg Effect: Role of lactate in carcinogenesis [2:27:00];

• Doping in cycling, and the trend towards altitude training [2:39:15] and;

• More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/inigosanmillan Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Today's episode of The Qualys is from podcast #25 – Scott Harrison: transformation, finding meaning, and taking on the global water crisis.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you're a subscriber, you can now listen to this full episode on your private RSS feed. You can also listen to this full episode on our website at the AMA #10 show notes page. We discuss:

• Does testosterone supplementation impact longevity? [2:40];
• Under what conditions does Peter decide to treat patients who have low testosterone? [8:50];
• Are there risks involved with testosterone replacement therapy? [17:10];
• How does Peter diagnose and treat hypothyroidism? [21:30];
• How might someone do time-restricted feeding while also adding muscle mass? [26:30];
• If building muscle requires higher levels of IGF-1, should we be concerned about longevity? [34:45];
• How to preserve muscle mass while fasting [41:45];
• Is it possible to simultaneously lose fat and add muscle mass? [46:30]; and
• More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/ama10 Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

In this episode, Bill Harris, Ph.D. in human nutrition and expert on omega-3 fatty acids, sets the table by clearly defining the families of fatty acids (saturated, monounsaturated, polyunsaturated) before diving into the current landscape of polyunsaturated fat (omega-6 and omega-3) with a particular focus on EPA and DHA (the two main elements of fish oil supplements). Bill gives a historical overview, updates us on the latest science related to the health benefits, and provides plenty of insights as to how we should think about increasing our EPA and DHA intake.

We discuss:

• Bill's long history of studying fatty acids [6:30];
• Defining the fatty acids—SFA, MUFA, PUFA, omega-3, omega-6, and more [9:45];
• What is the significance of fatty acids? Why should we care? [19:45];
• History of fat phobia, saturated fat, and does PUFA reduce cholesterol? [23:45];
• Breaking down the conversion process of omega-6 and omega-3 fatty acids including how we get to EPA and DHA [28:00];
• Takeaway from Bill's 1980 study looking at how salmon oil affected cholesterol and triglyceride levels [36:15];
• History of our understanding of omega-3 and its effect on LDL cholesterol [45:00];
• Prescribed fish oil drugs vs. OTC supplements—Differences and recommended brands [52:00];
• Health benefits of EPA [57:45];
• Potential benefits of ALA and how it compares to taking EPA and DHA directly [1:12:45];
• Health benefits of DHA [1:17:15];
• Cell membrane omega-3 index—What is it, the role of genetics, how to increase it, and a recommended target [1:19:00];
• Is EPA or DHA neuroprotective? Can it help with depression? [1:23:30];
• Recommended fish to eat for EPA and DHA - Any mercury concerns? [1:25:45];
• Can omega-3 mitigate risks associated with smoking? [1:29:15];
• The problem with the omega-6 to omega-3 ratio [1:30:00];
• The problem with labeling any kind of fatty acid as "bad" [1:36:00];
• Why increasing EPA and DHA intake matters more than reducing omega-6 intake [1:38:00];
• Important takeaway from the VITAL study [1:46:30];
• Importance of testing your omega-3 index [1:53:00];
• Exciting study coming out soon, and why you need to take your fish oil with food [1:57:15]; and
• More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/billharris Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Today's episode of The Qualys is from podcast #14 – Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD

In this episode, Mark Messier, six-time Stanley Cup champion, shares the most valuable lessons he picked up over 25+ years of professional hockey resulting in one of the longest and most decorated careers in hockey history. Mark shares what lead to his unique brand of humble leadership, how he was able to get talented individuals to effectively work as a team, the importance of maturing and evolving as a person, and how he was able to stay calm and perform at his best under enormous amounts of pressure. Additionally, we go through his favorite moments as a player, what it was like playing with and learning from The Great One, Wayne Gretzky, and much more.

We discuss:

• Overview of Mark's extraordinary 25+ year professional hockey career [7:15];
• The trend towards kids focusing on one sport earlier and earlier—A good or bad thing? [12:00];
• Mark's early passion for hockey, and when he realized it could be his "job" [14:15];
• Going pro at age 17 [19:30];
• Mark's favorite experience playing professional hockey [25:45];
• Playing with (and learning from) the great Wayne Gretzky [26:40];
• A hard lesson learned in his first year as a pro [32:00];
• Lessons learned from losing his first Stanley Cup Finals [35:45];
• Redemption—Winning his first Stanley Cup and the beginning of a dynasty in Edmonton [41:15];
• Importance of team character [54:00];
• The shocking trade of Wayne Gretzky, and Mark stepping up as the new leader and team captain [59:30];
• Playing for the New York Rangers—the lure of the city and the pressure to perform [1:07:00];
• Ending the 54-year championship drought for the New York Rangers [1:13:30];
• Becoming a great leader [1:16:30];
• How to win the mental war against your opponent [1:20:30];
• Opposing players for which Mark had great respect [1:22:00];
• Retiring after an unbelievably long and lustrous career [1:27:00];
• How to leverage stress and nervousness into a positive force [1:32:45];
• The most important quality—A willingness to learn, improve, and evolve [1:36:00];
• What does Mark do today for exercise to stay in great shape? [1:44:30];
• Why playing sports is such a great thing for kids [1:49:30];
• The Mark Messier Foundation [1:53:00];
• How has Mark avoided the "loss of identity" feeling which plagues many retired athletes? [1:56:15];
• Does Mark think it's possible to reproduce a team as good as his Oilers teams of the 80s? [1:59:30];
• Would Mark ever want to coach in the NHL? [2:03:00];
• Will the Toronto Maple Leafs ever win the Stanley cup? [2:04:00]; and
• More.

Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/markmessier Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

Today's episode of The Qualys is from podcast #32 – Siddhartha Mukherjee, M.D., Ph.D.: new frontiers in cancer therapy, medicine, and the writing process.

The Qualys is a subscriber-exclusive podcast, released Tuesday through Friday, and published exclusively on our private, subscriber-only podcast feed. Qualys is short-hand for "qualifying round," which are typically the fastest laps driven in a race car—done before the race to determine starting position on the grid for race day. The Qualys are short (i.e., "fast"), typically less than ten minutes, and highlight the best questions, topics, and tactics discussed on The Drive.

Occasionally, we will also release an episode on the main podcast feed for non-subscribers, which is what you are listening to now.

Learn more: https://peterattiamd.com/podcast/qualys/

Subscribe to receive access to all episodes of The Qualys (and other exclusive subscriber-only content): https://peterattiamd.com/subscribe/

Connect with Peter on Facebook.com/PeterAttiaMD | Twitter.com/PeterAttiaMD | Instagram.com/PeterAttiaMD