The Proof with Simon Hill

The Proof with Simon Hill

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  • Typical duration

    99 min

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The Proof with Simon Hill episodes

  • The Case for Treating Cholesterol Before Plaque Appears | Dr Thomas Dayspring and Dr Dan Soffer

    Almost all of us have atherosclerosis, and almost none of us are told so, because "normal" cholesterol is a population average rather than a physiological target. Dr Thomas Dayspring and Dr Dan Soffer, both Masters of the National Lipid Association, join me for a conversation devoted entirely to primary prevention.

    They do not agree on everything, and that is the point. Tom argues ApoB is the cause of atherosclerosis. Dan calls it the necessary substrate. Between them you get an unusually honest look at how two experienced clinicians weigh evidence, uncertainty, and their own bias when treating someone who feels perfectly well.

    What We Cover:

    • Why genes matter less for atherosclerosis than most people assume
    • Is ApoB causal, or simply necessary? The disagreement, in full
    • What "normal" cholesterol means, and the levels we are born with
    • LDL-C years: a five-second calculation you can run on yourself
    • What the 2026 dyslipidemia guideline changed
    • How they would manage a healthy man in his thirties with a family history and an ApoB of 100
    • Statin muscle symptoms, and the simple test that settles it
    • If you have ever been told your cholesterol is fine and wondered what that actually means, start here.

      To connect with Dr Thomas Dayspring, find him on X, where he posts as @Drlipid. To connect with Dr Daniel Soffer, visit his Penn Medicine profile.

      Want to support the show?

      The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

      This episode is brought to you by:

      38TERA

      Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

      38Tera ships to the United States, Australia, and New Zealand.

      Skylight

      Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.

      Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.

      Pique

      Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.

      Pique ships within the U.S. and to Australia, Canada, and select EU countries.

      Function Health

      Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

      Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

      Shopify

      Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.

      IM8

      With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

      IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

      WHOOP

      Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

      Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

      Simon Hill, MSc, BSc (Hons)

      • Creator of theproof.com
      • Host of The Proof with Simon Hill
      • Author of The Proof is in the Plants
      • Subscribe & Connect:

        • YouTube
        • Apple Podcasts
        • Spotify
        • Instagram: @simonhill
        • Twitter: @theproof
        • Facebook: The Proof with Simon Hill
        • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

          1 hr 43 min
        • Bone Health, Falls, Medications & Healthy Longevity | Dr Deborah Kado

          Everyone wants to talk about longevity. Almost no one wants to talk about gerontology, the field that has been studying how to age well for a century. Dr Deborah Kado, Stanford professor of medicine and geriatrician, joins me to bridge that gap.

          From bone health and balance to deprescribing, gut microbiome research, and the surprising power of your attitude towards ageing, this is a masterclass in what actually matters for a long, well-lived life.

          What We Cover:

          • Why "longevity science" is largely gerontology rebranded
          • A positive attitude towards ageing and its link to lower dementia risk
          • Balance, power training, and preventing falls and fractures
          • The truth about osteoporosis medications and the scare that drove millions away
          • Why extra weight after menopause can be protective
          • Vitamin D, sleep regularity, and the gut microbiome
          • This one will change how you think about growing older, whatever your age.

            To connect with Dr Deborah Kado, visit her Stanford profile or find her on LinkedIn.

            Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.

            Want to support the show?

            The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

            This episode is brought to you by:

            38TERA

            Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

            38Tera ships to the United States, Australia, and New Zealand.

            ProLon

            ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF.

            ProLon ships within the United States.

            SwimClub

            SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.

            IM8

            With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

            IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

            Function Health

            Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

            Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

            WHOOP

            Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

            Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

            Simon Hill, MSc, BSc (Hons)

            • Creator of theproof.com
            • Host of The Proof with Simon Hill
            • Author of The Proof is in the Plants
            • Subscribe & Connect:

              • YouTube
              • Apple Podcasts
              • Spotify
              • Instagram: @simonhill
              • Twitter: @theproof
              • Facebook: The Proof with Simon Hill
              • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                1 hr 36 min
              • Type 2 Diabetes Remission in the GLP-1 Era | Prof Roy Taylor

                Professor Roy Taylor returns, three years after his first appearance, with the five-year DiRECT trial results and a clear-eyed assessment of where diet-driven type 2 diabetes remission stands in the GLP-1 era.

                The evidence is now solid: type 2 diabetes is, for many, a reversible condition of excess fat in the liver and pancreas. But keeping it in remission demands keeping the weight off, and the new generation of weight loss drugs comes with marketing claims that Roy says have no evidence behind them.

                What We Cover:

                • The Twin Cycle Hypothesis and personal fat threshold
                • Five-year DiRECT data: durable remission, halved hospital admissions, fewer cancers
                • Why regaining the weight means the diabetes returns
                • GLP-1s: what they genuinely do, and what's marketing
                • The muscle loss panic, put in perspective
                • Gestational diabetes and pre-pregnancy weight
                • Whether you have type 2 diabetes, care for someone who does, or simply want to understand one of the biggest shifts in modern medicine, this conversation delivers.

                  To learn more about Professor Roy Taylor's work, visit his research site at Newcastle University or read his book Life Without Diabetes. Clinicians can also explore his type 2 diabetes remission toolkit for general practice.

                  Enjoyed this episode? A rating and review on the Apple Podcast app helps more people find the show.

                  Want to support the show?

                  The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                  This episode is brought to you by:

                  38TERA

                  Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                  38Tera ships to the United States, Australia, and New Zealand.

                  Upwork

                  Post your job for free at Upwork.com and connect with top talent ready to help your business grow. Find the right talent to support your business and bring your projects to life.

                  Function Health

                  Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                  Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                  Momentous

                  My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

                  Momentous ships to many countries worldwide depending on local import regulations.

                  HomeServe

                  Help protect your home systems – and your wallet – with HomeServe against covered repairs. Plans start at just $4.99 a month. Go to HomeServe.com to find the plan that’s right for you.

                  HomeServe is not available everywhere. Most plans range between $4.99 to $11.99 a month your first year. Terms apply on covered repairs.

                  Skylight

                  Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.

                  Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.

                  WHOOP

                  Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                  Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                  Simon Hill, MSc, BSc (Hons)

                  • Creator of theproof.com
                  • Host of The Proof with Simon Hill
                  • Author of The Proof is in the Plants
                  • Subscribe & Connect:

                    • YouTube
                    • Apple Podcasts
                    • Spotify
                    • Instagram: @simonhill
                    • Twitter: @theproof
                    • Facebook: The Proof with Simon Hill
                    • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                      1 hr 25 min
                    • Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess

                      Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, registered dietitian and Senior Research Fellow at the University of Oxford, says the evidence is clear: a higher-protein, lower-carbohydrate diet can lower post-meal glucose by more than medication, no weight loss required.

                      We also tackle the noisier end of the blood sugar conversation: glucose spikes, fruit fear, insulin-first theories of obesity, and the panic about GLP-1s and muscle loss.

                      What We Cover:

                      • Why glucose only causes direct harm at diabetic levels
                      • How protein wakes up "sleepy" beta cells
                      • What overfeeding trials reveal about insulin and obesity
                      • Fruit, fibre, and fat quality: what matters and what doesn't
                      • Menopause, PCOS, and shift work
                      • The truth about GLP-1s and muscle loss
                      • If you want a clear-eyed guide to metabolic health without the hype, this episode delivers.

                        To connect with Dr Nicola Guess, visit nicolaguess.com or find her on Instagram and YouTube.

                        Want to support the show?

                        The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                        This episode is brought to you by:

                        38TERA

                        Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                        38Tera ships to the United States, Australia, and New Zealand.

                        Function Health

                        Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                        Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                        Shopify

                        Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.

                        Eight Sleep

                        Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.

                        Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

                        IM8

                        With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

                        IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

                        WHOOP

                        Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                        Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                        Simon Hill, MSc, BSc (Hons)

                        • Creator of theproof.com
                        • Host of The Proof with Simon Hill
                        • Author of The Proof is in the Plants
                        • Subscribe & Connect:

                          • YouTube
                          • Apple Podcasts
                          • Spotify
                          • Instagram: @simonhill
                          • Twitter: @theproof
                          • Facebook: The Proof with Simon Hill
                          • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                            1 hr 9 min
                          • The Fertility Test Most Men Are Never Offered | Dr Michael Eisenberg and Dr Natalie Crawford

                            About one in seven couples are unable to conceive after a year of trying, and roughly half of those cases involve a male contribution. Yet in a quarter to a third of them, the man is never properly evaluated. In this episode I sit down with Dr Michael Eisenberg, a urologist, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, and Dr Natalie Crawford, a reproductive endocrinologist and co-founder of Fora Fertility in Austin, Texas.

                            This is the comprehensive male fertility resource I went looking for and couldn't find, and I have a personal stake in it. What surprised me most is that sperm health appears to be about much more than conception. It tracks with metabolic health, immune health, pregnancy outcomes, and in one Danish cohort, with age of death decades later.

                            What We Cover

                            • What a semen analysis measures, and why ejaculating normally tells you nothing
                            • Semen quality as a sixth vital sign, and the Danish study linking it to lifespan
                            • Testosterone therapy, why it functions as a contraceptive, and how long recovery takes
                            • Whether sperm counts are really declining, and the likely drivers
                            • Cannabis, alcohol, heat, cycling, sleep, and body weight
                            • Total motile sperm count, DNA fragmentation, and what to ask your lab for
                            • Paternal age, sperm freezing, and timing your decisions
                            • Sperm turn over roughly every three months, which makes this one of the most movable metrics in health. Whichever stage of life you're at, this conversation is worth your time.

                              To connect with Dr Michael Eisenberg, find him on Instagram or LinkedIn. To connect with Dr Natalie Crawford, you can find her book The Fertility Formula at nataliecrawfordmd.com/book, listen to her podcast As a Woman, or follow her on Instagram, TikTok, YouTube, and LinkedIn.

                              If this episode was useful, please leave a rating and review on Apple Podcasts. It genuinely helps more people find the show.

                              Want to support the show?

                              The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                              This episode is brought to you by:

                              38TERA

                              Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                              38Tera ships to the United States, Australia, and New Zealand.

                              IM8

                              With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

                              IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

                              Pique

                              Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.

                              Pique ships within the U.S. and to Australia, Canada, and select EU countries.

                              Skylight

                              Families are better when they’re working together. Right now, Skylight is offering our listeners $30 off their 15 inch Calendars by going to MySkylight.com/THEPROOF.

                              Skylight ships within the U.S. and to Canada, Australia, and the United Kingdom.

                              Function Health

                              Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                              Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                              WHOOP

                              Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                              Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                              Simon Hill, MSc, BSc (Hons)

                              • Creator of theproof.com
                              • Host of The Proof with Simon Hill
                              • Author of The Proof is in the Plants
                              • Subscribe & Connect:

                                • YouTube
                                • Apple Podcasts
                                • Spotify
                                • Instagram: @simonhill
                                • Twitter: @theproof
                                • Facebook: The Proof with Simon Hill
                                • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                  2 hr 4 min
                                • Superagers, statins, the latest cholesterol pill and the truth about heart disease risk | Dr Terry Simpson

                                  Dr Terry Simpson is back, and we go deep on the science of protecting your heart and brain for the long run. He is a surgeon and one of the clearest voices online for separating solid evidence from confident hype, and in this conversation we tackle everything from new cholesterol-lowering drugs to gene editing, cognitive ageing, and the lean mass hyperresponder debate.

                                  Along the way we get a few things off our chests about the misinformation that spreads faster than the careful answer ever can.

                                  What We Cover

                                  • Why healthy ageing brains owe more to lifestyle than to genetics
                                  • How PCSK9 inhibitors work, and why plaque is more like geology than plumbing
                                  • Gene editing for cholesterol and functional cures for type 1 diabetes
                                  • The lean mass hyperresponder debate and what the Keto-CTA re-analysis shows
                                  • Why colorectal cancer is rising in younger adults
                                  • The 2026 dyslipidemia guidelines and why you should test your Lp(a) once
                                  • This is a grounded, evidence-first conversation, and I hope it helps you feel clearer and more confident about the decisions that actually move the needle. If you enjoy the episode, please take a moment to rate and review the show, it genuinely helps more people find it.

                                    To connect with Dr Terry Simpson, visit terrysimpson.com, where you will find his bio, recipes, and plenty more. You can also follow him on Instagram, X, and TikTok, and read his writing on Substack.

                                    Want to support the show?

                                    The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                                    This episode is brought to you by:

                                    38TERA

                                    Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                                    38Tera ships to the United States, Australia, and New Zealand.

                                    Momentous

                                    My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

                                    Momentous ships to many countries worldwide depending on local import regulations.

                                    Eight Sleep

                                    Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.

                                    Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

                                    Function Health

                                    Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                                    Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                                    LMNT

                                    Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked.

                                    LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S.

                                    WHOOP

                                    Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                                    Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                                    Simon Hill, MSc, BSc (Hons)

                                    • Creator of theproof.com
                                    • Host of The Proof with Simon Hill
                                    • Author of The Proof is in the Plants
                                    • Subscribe & Connect:

                                      • YouTube
                                      • Apple Podcasts
                                      • Spotify
                                      • Instagram: @simonhill
                                      • Twitter: @theproof
                                      • Facebook: The Proof with Simon Hill
                                      • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                        1 hr 54 min
                                      • The Science of Metabolic Flexibility, Zone 2, and Reversing Diabetes | A Masterclass

                                        Metabolic dysfunction rarely announces itself. We tend to think of metabolic health as a line you cross the day you are diagnosed with type 2 diabetes, but the decay usually begins years earlier, at the level of the cell. In this masterclass I bring together Dr Iñigo San Millán, Dr Alan Flanagan, Dr Kevin Hall, Dr Robert Eckel, Professor Roy Taylor, and Dr Christos Mantzoros to explain what metabolic flexibility is, why your mitochondria sit at the centre of it, and what you can actually do about it.

                                        What We Cover

                                        • Why lactate is a fuel and a signal, not a waste product, and our best non-invasive window into mitochondrial function
                                        • Whether a calorie really is a calorie, and what the controlled chamber studies found
                                        • The twin cycle hypothesis, and why type 2 diabetes is more reversible than we were taught
                                        • The personal fat threshold, and why a normal BMI can still hide a problem
                                        • Whether sugar or saturated fat does more to drive fat in the liver
                                        • Why Zone 2 earns its reputation, and how much of it you actually need
                                        • Metabolic health is not fixed, and it is rarely too late to move in a better direction. I hope this conversation gives you a clearer picture of what is happening beneath the surface, and a few levers you can start pulling today.

                                          To learn more from the experts featured in this masterclass, you can follow Dr Iñigo San Millán on Instagram and Twitter, explore Professor Roy Taylor's work on type 2 diabetes remission at Newcastle University, read more from Dr Kevin Hall at kevinhallphd.com or on LinkedIn, and find Dr Alan Flanagan on Instagram and through Alinea Nutrition. The masterclass also features insights from Dr Robert Eckel and Dr Christos Mantzoros.

                                          If you are enjoying The Proof, please take a moment to rate and review the show on Apple Podcasts. It genuinely helps more people find these conversations.

                                          • The 81-Year-Old Who Reversed 30 Years of Damage (00:00)
                                          • What Metabolic Health Actually Means Now (01:57)
                                          • Why Mitochondria Decide Your Disease Risk (06:01)
                                          • What Is Metabolic Flexibility? (12:47)
                                          • Hepatic Fat Oxidation and the Sex Difference (15:20)
                                          • Is a Calorie Really a Calorie? (18:29)
                                          • You Can Be Sick Before You're Diagnosed (28:41)
                                          • Why Lactate Is the Biomarker to Watch (29:20)
                                          • Lactate Is Not a Waste Product (31:03)
                                          • Is Lactic Acid Burn a Myth? (36:42)
                                          • Why Athletes Clear Lactate and You Don't (40:34)
                                          • When High Lactate Predicts Death (43:01)
                                          • The Study That Found Damage in Healthy People (47:13)
                                          • The Lactate Test That Beats Blood Sugar (54:31)
                                          • Training Zones 1 to 6 Explained by Fuel (58:50)
                                          • Why Zone 2 Builds Mitochondria Best (1:09:18)
                                          • How to Know You're in Zone 2 Without a Lab (1:16:50)
                                          • Is 150 Minutes a Week Enough? (1:23:39)
                                          • Why You Still Need High Intensity Training (1:28:10)
                                          • What Obesity Research Got Wrong (1:31:44)
                                          • The Twin Cycle Hypothesis of Type 2 Diabetes (1:35:04)
                                          • Your Personal Fat Threshold Explained (1:42:26)
                                          • Why Some People Store Fat Safely (1:45:45)
                                          • Why BMI Fails as a Health Measure (1:51:29)
                                          • Sugar or Saturated Fat: What Drives Liver Fat? (1:55:07)
                                          • 15kg Weight Loss and Diabetes Remission (2:01:05)
                                          • Does Weight Loss Really Destroy Muscle? (2:04:39)
                                          • Why Exercise Alone Doesn't Drop Weight (2:07:05)
                                          • 3 Tests That Reveal Your Metabolic Health (2:11:14)
                                          • What Blue Zones Get Right About Movement (2:17:40)
                                          • Want to support the show?

                                            The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                                            This episode is brought to you by:

                                            38TERA

                                            Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                                            38Tera ships to the United States, Australia, and New Zealand.

                                            Function Health

                                            Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                                            Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                                            Momentous

                                            My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

                                            Momentous ships to many countries worldwide depending on local import regulations.

                                            Truemed

                                            Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars.

                                            IM8

                                            With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

                                            IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

                                            WHOOP

                                            Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                                            Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                                            Simon Hill, MSc, BSc (Hons)

                                            • Creator of theproof.com
                                            • Host of The Proof with Simon Hill
                                            • Author of The Proof is in the Plants
                                            • Subscribe & Connect:

                                              • YouTube
                                              • Apple Podcasts
                                              • Spotify
                                              • Instagram: @simonhill
                                              • Twitter: @theproof
                                              • Facebook: The Proof with Simon Hill
                                              • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                                2 hr 21 min
                                              • New Science of Weight Loss | A Masterclass

                                                GLP-1 medications are transforming obesity treatment, but they're only one piece of the puzzle. In this masterclass, I bring together insights from Dr Terry Simpson, Dr Federica Amati, Dr Mauricio Gonzalez, Dr Christos Mantzoros, and Dr Stephan Guyenet to explain how these medications work, why "food noise" matters, and what it really takes to improve long-term metabolic health.

                                                What We Cover

                                                • How GLP-1 medications regulate appetite and food noise
                                                • Why obesity is more complex than willpower
                                                • Semaglutide vs tirzepatide and newer medications
                                                • Nutrition and resistance training while taking GLP-1s
                                                • The role of fibre, protein, and Mediterranean-style eating
                                                • Common misconceptions and side effects
                                                • I hope this episode helps you better understand both the promise and the limitations of GLP-1 medications, while highlighting the importance of lifestyle alongside any medical treatment.

                                                  • Why Terry Simpson Started Taking a GLP-1 (00:00)
                                                  • What Is Food Noise, Really? (04:59)
                                                  • Why GLP-1 Drugs Work So Well (10:16)
                                                  • What Actually Causes Obesity (17:37)
                                                  • How GLP-1 Medications Work in the Body (21:22)
                                                  • The Strange Lizard Behind GLP-1 Drugs (25:56)
                                                  • 3 Types of Hunger You Didn't Know About (28:41)
                                                  • How to Naturally Boost Fullness Signals (37:08)
                                                  • How Doctors Choose Which GLP-1 to Prescribe (45:10)
                                                  • Why Some People Don't Respond to GLP-1s (53:09)
                                                  • GLP-1 Side Effects, Guilt, and Eating Right (58:12)
                                                  • Mediterranean Diet's Effect on Long-Term Weight Loss (01:10:29)
                                                  • The Shame Around Taking GLP-1 Medications (01:20:00)
                                                  • Being Called a Pharma Shill (01:32:39)
                                                  • The History Behind GLP-1 Drugs (01:38:18)
                                                  • Will You Need GLP-1s Forever? (01:47:04)
                                                  • Want to support the show?

                                                    The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                                                    This episode is brought to you by:

                                                    38TERA

                                                    Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                                                    38Tera ships to the United States, Australia, and New Zealand.

                                                    Eight Sleep

                                                    Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $350 off. You get 30 days to try it at home and return it if you don't love it.

                                                    Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

                                                    ProLon

                                                    ProLon’s 5-Day Fasting Mimicking Diet is a science-backed, plant-based program designed to support metabolic health while keeping your body in a fasting-like state. Get 15% off sitewide plus a $40 bonus gift at ProLonLife.com/THEPROOF.

                                                    ProLon ships within the United States.

                                                    SwimClub

                                                    SwimClub is a science-backed supplement designed to support male fertility, sperm health, and reproductive wellness. Head to swimclub.co to get 25% off your first order with code THEPROOF.

                                                    Function Health

                                                    Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                                                    Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                                                    WHOOP

                                                    Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                                                    Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                                                    Simon Hill, MSc, BSc (Hons)

                                                    • Creator of theproof.com
                                                    • Host of The Proof with Simon Hill
                                                    • Author of The Proof is in the Plants
                                                    • Subscribe & Connect:

                                                      • YouTube
                                                      • Apple Podcasts
                                                      • Spotify
                                                      • Instagram: @simonhill
                                                      • Twitter: @theproof
                                                      • Facebook: The Proof with Simon Hill
                                                      • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                                        1 hr 55 min
                                                      • Fertility, Sperm Health, and Nutrition Before and During Pregnancy | Dr Federica Amati

                                                        We tend to treat pregnancy as the starting line for a child's health. In this episode, Dr Federica Amati, Head Nutritionist at ZOE, makes the evidence-based case that the window opens earlier, in the months before conception, and that it shapes fertility and lifelong health in ways most of us were never told.

                                                        What I valued most is her balance. The science is striking, but she frames it as information to act on rather than a reason for guilt, and she is honest about how much sits with environment and policy rather than individual choice.

                                                        What we cover:

                                                        • Why the first 1,000 days may be the longevity lever almost no one talks about
                                                        • How a father's metabolic health links to his child's brain, and a mother's to their metabolism
                                                        • The 90-day preconception window, and what both partners can do
                                                        • What the decline in sperm counts really means for individuals
                                                        • GLP-1 medications, fertility, and a contraception detail too few people hear
                                                        • Protein, eggs, soy, and choosing a prenatal supplement, myths included
                                                        • Whether you are planning a pregnancy, supporting a partner, or simply curious about how much of our health is set before birth, I think this one will stay with you.

                                                          To connect with Dr Federica Amati, follow her on Instagram and explore her work at ZOE.

                                                          If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify. It genuinely helps more people find these conversations.

                                                          • Intro (00:00)
                                                          • Why Your Baby's Health Is Set Before Birth (03:13)
                                                          • Dr. Federica Amati's Background in Maternal Nutrition (07:41)
                                                          • What 48 of 52 Cell Differentiations Means for Your Baby (15:33)
                                                          • How Egg and Sperm Health Drive Conception Outcomes (21:40)
                                                          • Does What You Do Preconception Affect the Baby Too (26:09)
                                                          • Sperm DNA and Placental Health: The Father's Hidden Role (30:39)
                                                          • Heat, Laptops, and Sauna: What Kills Sperm Quality (32:56)
                                                          • Is the 50% Sperm Count Decline Real (39:32)
                                                          • Soy Foods, Testosterone, and Male Fertility Myths Debunked (44:30)
                                                          • Foods to Avoid in the 90-Day Preconception Window (48:10)
                                                          • GLP-1 Drugs, Fertility, and Unplanned Pregnancies (54:28)
                                                          • First Trimester Nausea: What Actually Helps (59:42)
                                                          • How to Choose a Prenatal Supplement (01:04:34)
                                                          • How Much Protein Do You Actually Need in Pregnancy (01:07:30)
                                                          • Can a Plant-Based Diet Work During Pregnancy (01:11:59)
                                                          • Tylenol in Pregnancy: Is It Safe (01:15:55)
                                                          • Want to support the show?

                                                            The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                                                            We'd love your feedback. Complete our quick 2-minute audience survey to help us better understand what content, topics, and guests you enjoy most. Take the survey at voicingchange.media/simon.

                                                            This episode is brought to you by:

                                                            38TERA

                                                            Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                                                            38Tera ships to the United States, Australia, and New Zealand.

                                                            IM8

                                                            With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com.

                                                            IM8 ships to 27 countries including the U.S., Canada, the U.K., Australia, and many regions across Europe, Asia, and South America.

                                                            Function Health

                                                            Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.

                                                            Function Health ships to 48 U.S. states, excluding Rhode Island, Hawai‘i, and Puerto Rico.

                                                            Pique

                                                            Pique’s Nandaka combines fermented Pu’er tea, full-spectrum Reishi, ceremonial cacao, and L-theanine for calm, sustained energy without the coffee crash. Unlock 20% off and establish your powerful foundation for sustained well-being at Piquelife.com/SIMON.

                                                            Pique ships within the U.S. and to Australia, Canada, and select EU countries.

                                                            Truemed

                                                            Truemed helps qualified customers use pre-tax HSA or FSA dollars on health-related products like fitness, recovery, and sleep tools, often saving around 30% on average. Visit truemed.com/THEPROOF to see what qualifies. This is hands down the best way to make the most of your health dollars.

                                                            WHOOP

                                                            Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                                                            Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                                                            Simon Hill, MSc, BSc (Hons)

                                                            • Creator of theproof.com
                                                            • Host of The Proof with Simon Hill
                                                            • Author of The Proof is in the Plants
                                                            • Subscribe & Connect:

                                                              • YouTube
                                                              • Apple Podcasts
                                                              • Spotify
                                                              • Instagram: @simonhill
                                                              • Twitter: @theproof
                                                              • Facebook: The Proof with Simon Hill
                                                              • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                                                1 hr 24 min
                                                              • Can You Reverse Heart Disease? What My Plaque Scans Showed | Dr Campbell Rogers

                                                                In late 2024 a CT scan revealed a small amount of soft plaque in my arteries. Sixteen months later I scanned again, and my plaque volume had dropped by around forty percent. In this episode I ask the cardiologist behind the technology whether a result like that can really be trusted.

                                                                Dr Campbell Rogers is an interventional cardiologist, a former Harvard faculty member who ran the cath lab at Brigham and Women's Hospital, and now Chief Medical Officer at Heartflow.

                                                                What we cover:

                                                                • The difference between a calcium score, a CT coronary angiogram, and AI plaque analysis
                                                                • Why a calcium score of zero does not mean you are free of disease
                                                                • What my own scans showed, and why Campbell believes the result
                                                                • Soft versus calcified plaque, and why calcification can be a sign of stabilisation
                                                                • Treating the plaque you can see rather than just an ApoB number
                                                                • Who should consider getting scanned, and the honest trade-offs
                                                                • This is a conversation about seeing a disease we used to only guess at, held with the right amount of scientific humility. If you want to understand your own heart health, I think it is well worth your time.

                                                                  If you enjoy the show, please take a moment to rate and review The Proof on Apple Podcasts or Spotify. It genuinely helps more people find these conversations.

                                                                  To connect with Dr Campbell Rogers, visit Heartflow.

                                                                  • How Campbell Rogers went from cardiologist to Heartflow (00:00)
                                                                  • What Heartflow is and how it works (07:26)
                                                                  • Coronary CT angiogram vs. stress test (11:54)
                                                                  • Why symptoms alone miss early heart disease (13:18)
                                                                  • How Heartflow analyzes CT scans in 90 minutes (15:58)
                                                                  • Calcified vs. non-calcified plaque: which is riskier (21:28)
                                                                  • Why calcium score zero doesn't mean no heart disease (28:45)
                                                                  • Who should get a CT angiogram with AI plaque analysis (31:09)
                                                                  • Why seeing your plaque improves medication adherence (34:04)
                                                                  • Simon's 2024 Heartflow scan results (39:12)
                                                                  • How plaque rupture triggers a heart attack (43:25)
                                                                  • Simon's 2026 Heartflow scan: 40% plaque reduction in 16 months (45:43)
                                                                  • How long to wait between CT scans (51:14)
                                                                  • Heartflow vs. Cleerly vs. QAngio (53:12)
                                                                  • How Heartflow results led Simon to start statins (58:21)
                                                                  • JAMA study: Heartflow tracks plaque in prostate cancer patients (1:00:10)
                                                                  • What is low attenuation plaque and why it's high risk (1:02:53)
                                                                  • Who should ask their doctor about a coronary CT angiogram (1:07:37)
                                                                  • Want to support the show?

                                                                    The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. You can also support the show by leaving a review on the Apple Podcast app and sharing your favourite episodes with friends and family.

                                                                    We'd love your feedback. Complete our quick 2-minute audience survey to help us better understand what content, topics, and guests you enjoy most. Take the survey at voicingchange.media/simon.

                                                                    This episode is brought to you by:

                                                                    38TERA

                                                                    Consider 38TERA's DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

                                                                    38Tera ships to the United States, Australia, and New Zealand.

                                                                    Eight Sleep

                                                                    Upgrade your sleep with the Pod 5 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF at eightsleep.com/theproof for up to $500 off. The 4th of July sale ends July 12, and you get 30 days to try it at home and return it if you don't love it.

                                                                    Eight Sleep ships to the U.S. (excluding Alaska, Hawaii, and territories), Canada, Mexico, most of the EU, the U.K., Australia, the UAE, Saudi Arabia, and Switzerland.

                                                                    LMNT

                                                                    Stay hydrated with LMNT. Get a free Sample Pack of LMNT’s most popular drink mix flavours with any purchase at DrinkLMNT.com/SIMON Find your favourite LMNT flavour, or share with a friend. And if you don’t like it? Full refund, no questions asked.

                                                                    LMNT ships to the U.S. and Canada, with sparkling flavors available only in the contiguous U.S.

                                                                    Shopify

                                                                    Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for your one-dollar-per-month trial at shopify.com/proof.

                                                                    Momentous

                                                                    My go-to supplement brand for protein and creatine is Momentous. Use code THEPROOF for up to 35% off your first order at livemomentous.com.

                                                                    Momentous ships to many countries worldwide depending on local import regulations.

                                                                    WHOOP

                                                                    Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

                                                                    Whoop ships to 56+ international markets, including the US, Canada, most of Europe, Australia, New Zealand, UAE, Singapore, and parts of Asia.

                                                                    Simon Hill, MSc, BSc (Hons)

                                                                    • Creator of theproof.com
                                                                    • Host of The Proof with Simon Hill
                                                                    • Author of The Proof is in the Plants
                                                                    • Subscribe & Connect:

                                                                      • YouTube
                                                                      • Apple Podcasts
                                                                      • Spotify
                                                                      • Instagram: @simonhill
                                                                      • Twitter: @theproof
                                                                      • Facebook: The Proof with Simon Hill
                                                                      • Nourish your gut with my Plant-Based Ferments Guide and download my Two-Week Meal Plan.

                                                                        1 hr 16 min

                                                                      About The Proof with Simon Hill

                                                                      From the publisher's feed

                                                                      The Proof Podcast is a space for science-based conversation. Together with his guests, Simon Hill, a qualified physiotherapist and nutritionist, explores the health and longevity benefits that come…

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