In this solo episode, Dave Lee tackles one of the trickiest parts of hormone optimization that doesn’t show up on lab work: your mind. He breaks down the placebo and nocebo effects, what “psychosomatic” actually means, and why your symptoms are real even when they’re driven by the brain—not just the bloodwork.

Dave explains how anxiety, over-monitoring every sensation, and trying to micromanage your TRT protocol from Reddit can completely derail your results, even when you’re working with a great provider. He lays out what it looks like to be a compliant, self-aware patient, why you must outsource protocol design to a competent clinician, and how to regulate your reactions so you don’t turn a good treatment plan into a car crash. This is a must-listen for both patients and providers navigating the messy intersection of biology, psychology, and hormone replacement therapy.

 

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