The TWiPsters solve the case of the Brazilian Immigrant With Heart Problems, and describe how genome organization controls trypanosome antigenic variation.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Links for this episode:

• Trypanosome genome organization and antigenic variation (Nature)
• Hero: Arthur Looss
• Letters read on TWiP 161

Case Study for TWiP 161

Daniel was asked to see 30 yo female from Bolivia, had to travel back during 3rd trimester. Was there for most of 3rd trimester. Child born in US, pericardial effusion, ascites, moderate PDA. Heart function is ok. Woman was healthy, no issues during pregnancy. Baby's white count elevated, diagnostic evaluation. It is a parasite.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees