Dr. Jeffery Gladden chats with Dr. Gil Blander, internationally recognized for his research in the basic biology of aging and for translating his discoveries into new ways of detecting and preventing age-related conditions. He received a Ph.D. in biology from the Weizmann Institute of Science and completed his postdoctoral fellowship at MIT. He has been featured in CNN Money, The New York Times, Forbes, The Financial Times, and The Boston Globe. He is also the founder of InsideTracker. In this episode, Dr. Gladden and Dr. Gil discuss how Dr. Gil's passion and expertise in longevity informed his decision to found InsideTracker. Drawing from his expertise Dr. Gill also touches on how blood work is an ideal foundation for creating personalized lifestyle protocols intended to optimize longevity and how "set variables" like DNA, gender, and ethnicity play into a personalized quest for longevity. If you want to know how much a person can really impact longevity markers with non-medical, nutrition, and lifestyle interventions, then this episode is for you.

Dr. Gladden welcome Dr. Blander. (1:20)

Dr. Blander shares his personal journey and how he got to start InsideTracker, and his background. (1:50)

Dr. Blander shares some insight into research that is ongoing on cellular senescence. Dr. Blander mentions his involvement in researching sirtuins, a gene found in yeast that can extend lifespan and cellular senescence, and the use of animal models in the research. (3:48)

Dr. Gladden mentions that sirtuins are a family of proteins essential for longevity, and we go to great lengths to try to activate sirtuins by various mechanisms. (8:05)

Dr. Gladden states how NAD/NADH ratio goes down with aging for various reasons. (10:41)

Dr. Blander mentions how he came to America, became an entrepreneur, developed a model for caloric restriction, and talked about processes that change with caloric restriction. (12:39)

Dr. Blander explained how he compared the signature of caloric restriction to mice treated with Resveratrol. (17:11)

Dr. Blander talks about how using a cocktail of supplements could mimic calorific restriction. (18:40)

Dr. Blander talks about the idea of optimizing our body, seeing what is happening inside our body, and fixing it using food. (20:11)

Dr. Bland talks about they are looking at blood biomarkers related to lipids, glucose metabolism, iron metabolism, and inflammation. He also spoke about how they are focused on biomarkers related to longevity instead of sickness. (22:00)

Dr. Blander mentions the optimal level of glucose which is between 65 - 99, whether you are young or old. (25:34)

Dr. Blander talks about the optimal glucose level for longevity and how it changes. (27:17)

Dr. Blander talks about how fasting glucose changes and is affected by stress, BMI, sleep, and exercise. (29:17)

Dr. Blander talks about inner and chronological age and how they are calculated. (35:16)

Dr. Blander talks about his approach that identifies the problem, why the problem happened, and the solution. (37:17)

Dr. Gladden talks about how intervention with food will affect more metrics that are being measured. (40:05)

Dr. Blander explains how InsideTraker fits into our daily strategy regarding health and longevity. (42:27)

Dr. Blander talks about changing your lifestyle in order to optimize yourself. (44:30)

Dr. Blander details how the program works and how you can select the goal you are after. (45:09)

Dr. Blander mentions that one of the essential things for longevity is building muscle and lifting weights, nutrition and sleep. (46:49)

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