In this episode of Demystifying PANS/PANDAS, I talk with TruDOSE leaders Tapley Holland and Elena Herning about how precision-dosed platelet therapy works to modulate immune dysfunction, calm neuroinflammation, and support healing in children and adults with complex conditions like autism and PANS/PANDAS.

When healing finally starts working, it doesn’t always look comfortable at first. In this episode of Demystifying PANS/PANDAS, Tapley Holland and Elena Herning join us to explore TruDOSE, an IV therapy using a patient’s own platelets, precisely dosed and retested to stimulate repair and immune balance rather than suppress symptoms.

They explain why the body doesn’t recognize diagnoses, only dysfunction, and how TruDOSE works systemically to modulate inflammation, immune signaling, and repair pathways. The conversation also dives into emerging research, early microbiome findings, real-world outcomes in autism and PANS/PANDAS, and why understanding why a therapy doesn’t work is just as important as celebrating when it does.

Tapley Holland and Elena Herning are the leaders behind TruDOSE, a precision-based IV platelet therapy focused on immune modulation and systemic repair. Their work centers on using a patient’s own platelets, carefully tested and retested for dose accuracy, to support healing across complex inflammatory, neurological, and immune-driven conditions.

Together, they are advancing TruDOSE through provider education and multiple IRB-backed research initiatives, including studies in autism, PANS/PANDAS, microbiome health, sports medicine, women’s health, and more, driven by a mission to better understand why therapies work, and sometimes don’t.

Tapley Holland and Elena Herning

Website: https://trudose.com

Nancy O’Hara, MD, MPH, FAAP, FMAPS

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