Dhru Purohit Show

Why Blood Sugar Regulation is a Key Part of Alzheimer’s Prevention


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This episode is brought to you by Cozy Earth and Pique Life.


We know the seeds of Alzheimer’s are planted at least twenty years before a diagnosis. So, it’s never too early to make crucial lifestyle changes that can influence brain health and the risk of developing neurodegenerative diseases. 


Today on The Dhru Purohit Show, we’re bringing you a special compilation episode featuring Dhru’s conversations with leading experts on Alzheimer’s and brain health. 

Dr. David Perlmutter explores the key factors that influence Alzheimer’s risk and shares his top lifestyle strategies for prevention. He also discusses tools to assess brain energy usage and dives into the gut-brain connection.


Dr. Mosconi explains what happens to a woman’s brain during menopause and its connection to Alzheimer’s disease. She also shares how recent research validates women's experiences in perimenopause and menopause, along with key lifestyle habits to prevent dementia and support a smoother transition.


Dr. Perlmutter is a board-certified neurologist and five-time New York Times bestselling author. He is a fellow of the American College of Nutrition and serves on their Board of Directors. He has published extensively in peer-reviewed scientific journals, including the Journal of Alzheimer’s Disease, Archives of Neurology, and Neurosurgery.


Lisa Mosconi, PhD, is an associate professor of neuroscience in neurology and radiology at Weill Cornell Medicine and the director of the Women’s Brain Initiative and the Alzheimer’s Prevention Clinic at Weill Cornell Medicine/NewYork-Presbyterian Hospital. She is the New York Times bestselling author of The XX Brain and Brain Food.


In this episode, Dhru and his guests dive into:

  • Genetics vs. Lifestyle: Their roles in diagnosis and impact on health (1:39)
  • How Insulin Resistance Affects the Brain: Compromised brain energetics (04:20)
  • Key ingredients that impact the body like sugar  (11:11)
  • Blood Sugar Game-Changers: Strategies for better management (20:14)
  • Foods Dr. Perlmutter avoids & the gut-brain connection (27:32)
  • The brain’s energy demands & top antioxidant-rich foods (34:32)
  • What’s happening in the brain during menopause (38:31)
  • Validating menopause symptoms and women’s experiences (47:32)
  • Brain changes in perimenopause & key transitions (52:02)
  • Why the brain is unique and why consistency is key (59:32)


  • Also mentioned:

    • Full episode with David Perlmutter
    • Full episode with Dr. Lisa Mosconi

    • This episode is brought to you by Cozy Earth and Pique Life.


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