ZOE Science & Nutrition

ZOE Science & Nutrition

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ZOE Science & Nutrition episodes

  • Hidden health risk? The truth about emulsifiers with Dr. Federica Amati

    Emulsifiers are common in our diets, enhancing the texture, appearance and shelf life of many foods. But are they safe?

    In today’s episode, Jonathan and Federica uncover the surprising truth about emulsifiers in our food. We learn the science behind emulsifiers, their impact on health, and the rising concerns over there extensive use in ultra-processed foods.

    Dr Federica Amati is a King’s College London researcher and a registered nutritionist. She is also a lecturer and Nutrition Topic Lead at Imperial College School of Medicine. Federica empowers people with accessible, practical knowledge to make informed choices on diet and lifestyle and to improve health based on unique needs and preferences, at every stage of life.

    Learn how your body responds to food 👉 zoe.com/podcast for 10% off

    🌱 Try our new plant based wholefood supplement - Daily 30

    *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

    Follow ZOE on Instagram.


    Timecodes

    00:00 Introduction

    01:10 What are emulsifiers doing in our food?

    02:15 How common are emulsifiers in our food?

    02:52 What to look out for on packaging

    03:55 What are emulsifiers made from?

    04:36 How emulsifiers work

    09:50 Are emulsifiers bad for us?

    10:40 Emulsifiers and our gut health

    11:50 New risks emerging from human studies

    14:50 How to reduce emulsifiers in your diet


    Buy Federica’s book: Every Body Should Know This 


    Free resources from ZOE:

    • Live Healthier: Top 10 Tips From ZOE Science & Nutrition 
    • Gut Guide - for a healthier microbiome in weeks

    • Mentioned in today’s episode:

      • Food additive emulsifiers: a review of their role in foods, Nutrition Reviews 
      • Emulsifiers Impact Colonic Length in Mice and Emulsifier Restriction is Feasible in People with Crohn’s Disease, Nutrients 2020
      • Food Additive Emulsifiers and Their Impact on Gut Microbiome, Permeability, and Inflammation, Journal of Crohn's and Colitis
      • Bacterial Overgrowth and Inflammation of Small Intestine After Carboxymethylcellulose Ingestion in Genetically Susceptible Mice, Inflammatory Bowel Diseases


        Have feedback or a topic you'd like us to cover? Let us know here.

        Episode transcripts are available here.

        28 min
      • Recap: The top foods high in pesticides | Prof. Tim Spector

        Today we’re talking about pesticides. More specifically, about the surprising levels of pesticides found in some common foods.

        Professor Tim Spector is here to tell us how to avoid giving these to our families.


        Learn how your body responds to food with ZOE 👉 start here


        📚 Books from our ZOE Scientists:

        - Food For Life by Prof. Tim Spector

        - Every Body Should Know This by Dr Federica Amati



        Mentioned in the episode:

        Dirty Dozen and Clean 15


        Have feedback or a topic you'd like us to cover? Let us know here

        Listen to the full episode here

        11 min
      • Can NASA research help fight cancer? | Dr Jessica Scott

        What do astronauts and cancer patients have in common? 

        Jonathan explores this fascinating connection with Dr. Jessica Scott, learning how six decades of NASA research is being used to help the recovery of cancer survivors. New research challenges the traditional notion that you should rest during cancer treatment. Instead, Jessica’s studies into exercise could hold the key to a long and healthy life post-diagnosis. 

        Dr Jessica Scott started her career at NASA where she spent 7 years designing exercise programs for astronauts in outer space. Now, as the principal investigator at the world-leading Memorial Sloan Kettering Cancer Center, she is using her unique skillset in the fight against cancer.

        ​​Learn how your body responds to food 👉 zoe.com/podcast for 10% off 

        Follow ZOE on Instagram.

        Timecodes:

        00:00 Introduction

        01:32 Quickfire questions

        03:10 Health challenges for astronauts

        07:19 Impact of exercise on astronauts

        10:43 NASA’s exercise program

        14:28 Transition to cancer research

        15:40 Exercise and cancer treatment

        17:10 Side effects of cancer treatments

        23:13 Studies on the benefit of exercising alongside cancer treatment

        26:27 Tailoring exercise to the individual 

        28:10 Global perspectives on exercising alongside cancer treatment

        29:47 Understanding different types of exercise

        33:26 Implementing NASA's non-linear exercise training techniques

        41:04 The next steps for Jessica’s research

        42:45 Episode summary


        Books by our ZOE Scientists:

        • Every Body Should Know This by Dr Federica Amati
        • Food For Life by Prof. Tim Spector
        • Fibre Fuelled by Dr Will Bulsiewicz

        • Studies related to today’s episode:

          • Cancer Survivorship Statistics from The National Cancer Institute https://cancercontrol.cancer.gov/ocs/statistics#stats
          • Multisystem Toxicity in Cancer: Lessons from NASA’s Countermeasures Program from The National Library of Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380275/
          • A randomised trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer from The National Library of Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965727/
          • Effects of exercise countermeasures on multisystem function in long duration spaceflight astronauts from The National Library of Medicine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898566/
          • Cardiovascular Disease Risk Among Cancer Survivors: The Atherosclerosis Risk In Communities (ARIC) Study from The National Library of Medicine https://pubmed.ncbi.nlm.nih.gov/35772913/

          • Have feedback or a topic you'd like us to cover? Let us know here. 

            Episode transcripts are available here.

            54 min
          • Obesity and the new science of weight loss | Dr. Louis J Aronne

            Obesity is a physiological condition that can be managed with the right education and treatment.

            In today's episode, Dr. Louis J. Aronne, a leading expert in obesity research, sheds light on the science behind weight management and obesity treatment.

            Dr. Aronne dives into groundbreaking weight loss medications. He also explores how lifestyle and eating habits affect long-term health and why medications combined with dietary changes can unlock transformative results.

            Louis J. Aronne, M.D. is a leading authority on obesity and its treatment. He’s a former president of The Obesity Society, which publishes the peer-reviewed scientific journal Obesity, of which Dr. Aronne is an associate editor. He has also authored more than 60 papers and book chapters on the topic. 

            🌱 Try our new plant based wholefood supplement - Daily 30

            *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

            Learn how your body responds to food 👉 zoe.com/podcast for 10% off

            Follow ZOE on Instagram.

            Timecodes

            00:00 Introduction

            01:01 Quickfire questions

            03:51 What is obesity?

            05:06 What’s the difference between overweight and obesity?

            07:38 Why has there been such a quick rise in obesity?

            10:55 Why it’s not just a lack of willpower

            13:50 The complexity of weight regulation

            15:54 What is Leptin and why is it so important for weight control?

            19:51 The brain’s role in weight regulation

            20:36 Curing obesity in animal studies

            22:29 Why hunter-gatherers did not gain weight

            23:58 Natural experiments in weight gain and loss

            26:01 How medications can cause weight gain

            28:42 The impact of calorie restriction diets

            30:13 Reducing diabetes risk through weight loss

            34:10 Research into medications as a tool for weight loss

            38:36 How well do weight loss drugs work?

            41:38 The future of weight loss drugs

            43:51 Will you regain the weight if you stop taking weight loss drugs?

            48:08 Can obesity be avoided without the use of drugs?

            49:42 Concerns about weight loss drugs

            Books by our ZOE Scientists:

            • Every Body Should Know This by Dr Federica Amati
            • Food For Life by Prof. Tim Spector
            • Fibre Fuelled by Dr Will Bulsiewicz

            • Mentioned in today's episode:

              • Persistent metabolic adaptation 6 years after "The Biggest Loser" competition in Obesity 
              • The Finnish diabetes prevention study (DPS) in Diabetes Care
              • The National Diabetes Prevention Program of the Centers for Disease Control and Prevention (CDC)


                Have feedback or a topic you'd like us to cover? Let us know here.

                Episode transcripts are available here.

                1 hr 1 min
              • Fix your body clock to improve long term health with Prof. Satchin Panda

                Our modern lifestyles mean that most of us don’t live our lives in sync with our circadian rhythms, which puts our health and well-being at risk. Eating and sleeping at the right time are important tools to help us align our circadian rhythms and reduce our risk of chronic disease. 

                In this episode, circadian rhythm expert Prof. Satchin Panda will tell us how light and food act as master regulators of our body clock, how aligning our lifestyles with our body clock can improve our health, mood and energy levels and how to do this in practice. 

                Satchin is a world-leading expert in the field of circadian rhythm research. He’s associate professor at the prestigious SALK institute, he’s recipient of the Dana Foundation Award in brain and immune system imaging and he’s also the author of two best-selling books, The Circadian Code and The Circadian Diabetes Code.

                Learn how your body responds to food 👉 zoe.com/podcast for 10% off

                🌱 Try our new plant based wholefood supplement - Daily 30

                *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system


                Timecodes:

                00:00 Introduction

                01:00 Quickfire questions

                03:02 What are circadian rhythms?

                03:48 How do we know about circadian rhythms?

                04:44 Are all body parts on a 24 hour clock?

                06:40 How the body enters sleep mode

                09:25 What happens during sleep?

                12:08 Why you’re not sleeping enough

                13:30 The surprising impact of daylight savings time

                17:00 Circadian rhythms aren’t just about light

                19:55 The dangers of shift work

                21:20 Should you go to bed at sunset?

                25:40 Why should stop snacking at night

                26:10 Satchin’s famous mice study

                33:00 The best eating window for health

                37:27 Does intermittent fasting promote better food choices?

                40:40 Should you drink black coffee when you wake up?

                 

                Satchin’s books:

                • The Circadian Code 
                • The Circadian Diabetes Code

                • Books by our ZOE Scientists:

                  • Every Body Should Know This by Dr Federica Amati
                  • Food For Life by Prof. Tim Spector
                  • Fibre Fuelled by Dr Will Bulsiewicz

                  • Studies referenced in today’s episode: 

                    • Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial, published in Lancet Healthy Longevity
                    • Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development, published iScience
                    • Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care, published in Trends Cancer
                    • The Untapped Potential of Circadian Timing as a Variable for Discoveries and Reproducibility, published in Cell Mol Gastroenterol Hepato


                      Follow ZOE on Instagram

                      Have feedback or a topic you'd like us to cover? Let us know here.

                      Episode transcripts are available here.

                      54 min
                    • Remembering Michael Mosley: 4 habits that changed his life

                      After the tragic news of Michael Mosley's passing, we are re-releasing our episode with him, originally released in March 2023:

                      If you had to do just one thing to improve your health, what would it be?

                      Our busy lives mean it can be difficult to keep up healthy habits, and with so much conflicting advice out there it’s tricky to separate fact from fiction. In today’s episode, Jonathan is joined by medical doctor, journalist, and presenter Michael Mosley, who is alongside ZOE regular Tim Spector, to discuss Michael’s four key habits to improve our health. 

                      Michael’s latest book ‘Just One Thing’ explores these habits and has seen him speak to singing scientists and eccentric iceman to healthy habit experts and evangelists. And of course, being Michael, he tried every habit out himself. We talk about which methods are the most effective, which he has incorporated into his life, and how he makes his new habits stick.

                      🌱 Try our new plant based wholefood supplement - Daily 30

                      *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system


                      If you want to uncover the right foods for your body, head to zoe.com/podcast and get 10% off your membership.

                      Follow ZOE on Instagram

                      Timecodes:

                      00:00 Tim Spector's tribute to Michael

                      01:01 Introduction

                      01:55 Quick Fire Questions

                      05:15 Are cold showers good for you?

                      06:48 How long do you need to be immersed in cold water for the benefits to work?

                      8:20 Can cold showers improve mental wellbeing?

                      11:30 Potential dangers of cold water swimming

                      12:45 Do cultural differences present different outcomes across the world?

                      13:58 Can these small stressors help us?

                      14:27 What is the theory behind this working?

                      16:15 Will this work for everyone or is this very personalized?

                      18:30 What effects does breathing have on your health?

                      19:55 How breathing exercises affect our brain

                      22:27 How do you keep up the breathing exercises?

                      23:27 ZOE app breathing exercise

                      25:40 Is there a difference between breathing through your nose and your mouth?

                      27:20 How important are plants and nature for our health?

                      30:25 Can exposure to nature improve things like mental health and even gut health?

                      32:00 Can herbs also help improve our health?

                      32:47 What are the benefits of exercise?

                      33:30 What are endo-cannibinoids?

                      34:41 Are preferences for exercise genetic?

                      36:12 Is it endorphins that make us feel good after / during exercise?

                      37:31 How exercise affects us is extremely personalized

                      39:42 How do we encourage people who don't enjoy exercise to do it?

                      41:13 Tips to improve your exercise routines

                      44:08 Are there benefits to walking downhill?

                      46:42 Summary

                      Michael Mosley’s book 'Just One Thing' is available to buy here

                      Episode transcripts are available here

                      53 min
                    • Is plant-based meat healthy? What the research shows with Prof. Christopher Gardner

                      Meat consumption continues to be high in both the US and the UK. Yet many governments advise reducing meat consumption, particularly red meat, due to both environmental and health concerns. 

                      In this episode, we delve into the sizzling world of meat alternatives. They promise sustainability, animal welfare, and better health. Buzzwords like "plant-based" and "meat-free" proudly adorn their packaging. But are they actually healthy? Or should we consider them as ultra-processed foods and avoid them?

                      Christopher Gardner is a Professor of Medicine at Stanford University and the Director of the Stanford Prevention Research Centre, and a world-leading expert in how the food that we eat impacts our health. 

                      🌱 Try our new plant based wholefood supplement - Daily 30

                      *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

                      Learn how your body responds to food 👉 zoe.com/podcast for 10% off

                      Follow ZOE on Instagram.

                      Timecodes:

                      00:00 Introduction

                      01:25 Quickfire questions

                      03:50 What is a meat alternative?

                      05:22 What's driving the trend for more alternatives?

                      07:47 Should you eat less red meat?

                      08:38 What is in meat alternatives?

                      10:22 Traditional meats vs meat alternatives

                      13:41 Are meat alternatives ultra-processed?

                      14:47 Latest scientific studies

                      23:56 What were the findings?

                      29:48 Is the quality of the protein as good as real meat?

                      34:00 Are meat alternatives healthy?

                      38:53 Are whole food based meat alternatives healthier?

                      40:05 What are the practical tips around meat alternatives?

                      43:21 How do ultra-processed foods come into this?

                      45:23 What are other ways people can transition away from red meat?

                      50:33 What are the differences between bad and good quality meat?

                      📚 Books from our ZOE Scientists:

                      • Every Body Should Know This by Dr Federica Amati
                      • Food For Life by Prof. Tim Spector
                      • Fibre Fuelled by Dr Will Bulsiewicz


                        Studies referenced in today’s episode: 

                        • Study With Appetizing Plantfood—Meat Eating Alternative Trial (SWAP-MEAT), published in American Journal of Clinical Nutrition.
                        • SWAP-MEAT Athlete (study with appetizing plant-food, meat eating alternatives trial) a randomized crossover trial, published in Nutrition Journal.


                          Have feedback or a topic you'd like us to cover? Let us know here.

                          Episode transcripts are available here.

                          1 hr 3 min
                        • Menstruation: Science, medicine and mythology

                          Periods are taboo! Despite the fact that half of the world’s population experience them. This taboo has led to countless myths around the topic. “The internet’s gynecologist” Dr. Jen Gunter is here to usher in a new era where people understand – and can advocate for – what they need as their body changes each cycle.

                          Jonathan is joined by Dr Sarah Berry and Dr Jen Gunter to get a better understanding of our body's behavior during the menstrual cycle. Jen will provide you with her period toolkit and offer solutions to the most common problems of modern-day period health.

                          Dr. Jen Gunter is a gynecologist and pain medicine physician at the Permanente Medical Group in northern California. Her books ‘The Vagina Bible’ and ‘The Menopause Manifesto’ were both New York Times bestsellers. Her 2024 book ‘Blood’ tackles the science, medicine and mythology of menstruation.

                          🌱 Try our new plant based wholefood supplement - Daily 30

                          *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

                          Learn how your body responds to food 👉 zoe.com/podcast for 10% off

                          Follow ZOE on Instagram.

                          Timecodes:

                          00:00 Introduction

                          01:26 Quickfire questions

                          02:31 Shame culture around menstruation

                          04:20 The evolution and purpose of the menstrual cycle

                          06:30 Menstrual cycle mechanics

                          11:08 Understanding heavy periods and iron deficiency

                          14:01 Addressing period pain and discomfort

                          21:39 Diet, appetite, and periods: what's the connection?

                          26:09 Understanding PMS and PMDD

                          27:55 PMS causes and symptoms

                          30:52 Treatment options for PMS and PMDD

                          31:51 Demystifying polycystic ovarian syndrome (PCOS)

                          35:42 The role of diet and obesity in PCOS

                          37:32 Advice for managing PMS

                          40:19 Menstrual cramps and pain management

                          47:08 Iron supplementation strategies

                          📚 Dr. Jen Gunter’s books:

                          • The Menopause Manifesto
                          • Blood: The Science, Medicine, and Mythology of Menstruation

                          • 📚 Books from our ZOE Scientists:

                            • Every Body Should Know This by Dr Federica Amati
                            • Recipes for a Better Menopause by Dr Federica Amati
                            • Food For Life by Prof. Tim Spector


                              Studies related to today’s episode:

                              • Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020, from the Journal of the American Medical Association
                              • The Role of Estrogen in Insulin Resistance: A Review of Clinical and Preclinical Data, from The American Journal of Pathology


                                Have feedback or a topic you'd like us to cover? Let us know here

                                Episode transcripts are available here.

                                58 min
                              • Why dementia could start in your blood vessels with Dr. William Li

                                55 million people suffer dementia worldwide with numbers expected to double every 20 years. Understanding the link between our heart health and brain function is critical, illuminating the profound impact that heart health has on preventing dementia.

                                Dr. William Li, an expert in cardiovascular and metabolic health. He reveals how caring for our heart is not just about longevity but maintaining sharp, effective brain function as we age. His groundbreaking work has impacted more than seventy diseases including diabetes, heart disease, and obesity. Dr. Li is also a New York Times best-selling author.

                                In today’s episode, Dr. Li explains how simple lifestyle choices in diet, exercise and sleep can drastically shape our brain's health and stave off dementia.

                                🌱 Try our new plant based wholefood supplement - Daily 30

                                *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

                                If you want to uncover the right foods for your body, 👉 zoe.com/podcast, for 10% off your membership.

                                Follow ZOE on Instagram

                                Timecodes

                                00:00 Introduction

                                01:23 Quickfire questions

                                03:30 Understanding dementia and Alzheimer's disease

                                04:50 Dementia versus ageing

                                06:35 The role of blood vessels in brain health

                                07:55 How circulation affects brain function

                                09:23 What causes blood clots and strokes?

                                11:06 The importance of maintaining healthy blood vessels

                                12:15 The impact of lifestyle choices on brain health

                                15:01 What happens in our brains when we sleep?

                                19:35 What is the glymphatic system?

                                22:40 Vascular dementia may be the most common form of dementia

                                24:35 The role of glucose in brain function

                                27:10 What causes dementia and why does it happen when we get older?

                                29:00 Preventing dementia with lifestyle changes

                                31:10 What are healthy blood vessels like?

                                37:50 The surprising role of EPCs in brain repair

                                41:30 Can you slow down or reverse dementia?

                                52:08 The connection between gut health and brain health

                                51:40 The importance of exercise for brain health

                                56:30 How to avoid dementia

                                01:01:16 The link between mental health and cardiovascular disease

                                📚 Dr. William Li’s books:

                                • Eat to Beat Disease
                                • Eat to Beat Your Diet

                                • 📚 Books from our ZOE Scientists:

                                  • Every Body Should Know This by Dr Federica Amati
                                  • Food For Life by Prof. Tim Spector

                                  • Relevant studies:

                                    • A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk, published in Nature
                                    • Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images, published in Science
                                    • Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial, published in The American Journal of Clinical Nutrition


                                      Have feedback or a topic you'd like us to cover? Let us know here

                                      Episode transcripts are available here.

                                      1 hr 16 min
                                    • How inflammation could age you with Prof. Philip Calder

                                      Inflammation is a complicated topic. Short-term inflammation plays an essential role in fighting infections and healing injuries. But too much inflammation can be a catalyst for chronic ailments, like heart disease, type 2 diabetes, autoimmune disorders, rheumatoid arthritis, and obesity.

                                      What we eat can influence our inflammatory responses and contribute to chronic, low-grade inflammation.

                                      In today’s episode, Prof. Philip Calder helps us understand the science behind inflammation, how it impacts our health and what food has to do with it.

                                      Philip is head of the School of Human Development and Health, as well as a Professor of Nutritional Immunology, in the Faculty of Medicine at the University of Southampton. He’s also an internationally recognised researcher on the metabolism and functionality of fatty acids. His work focuses on the roles of omega-3 fatty acids and the influence of diet and nutrients on immune and inflammatory responses. 

                                      🌱 Try our new plant based wholefood supplement - Daily 30

                                      *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system

                                      Learn how your body responds to food 👉 zoe.com/podcast for 10% off

                                      Follow ZOE on Instagram.

                                      Timecodes

                                      00:00 Introduction

                                      01:20 Quickfire questions

                                      02:55 The role of inflammation in immunity

                                      05:30 Chronic inflammation and disease

                                      08:30 How to measure inflammation

                                      09:53 Low-grade inflammation and disease risk

                                      12:30 What causes blood vessel inflammation?

                                      15:23 What creates the narrowing of blood vessels?

                                      17:20 How inflammation can cause blood clots, heart attacks and strokes

                                      19:15 Inflammation and aging

                                      21:40 Inflammation and lifestyle factors

                                      25:07 Obesity and inflammation

                                      28:45 Muscle loss and inflammation (sarcopenia)

                                      30:52 The impact of meals, sugar and fats on inflammation

                                      33:35 How diet could reduce inflammation

                                      34:42 Why we all respond to food differently

                                      38:42 Dietary choices to manage inflammation

                                      40:00 What are omega-3s?

                                      41:17 Anti-inflammatory foods

                                      43:40 Health benefits of omega-3 fatty acids

                                      45:55 Challenges with farmed salmon

                                      📚 Books from our ZOE Scientists:

                                      • Every Body Should Know This by Dr Federica Amati
                                      • Food For Life by Prof. Tim Spector

                                      • Mentioned in today's episode:

                                        Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? in the British Journal of Clinical Pharmacology

                                        Omega-6 fatty acids and inflammation in PLEFA

                                        Omega-3 fatty acids and inflammatory processes in Nutrients 

                                        Another relevant study:

                                        Health relevance of the modification of low-grade inflammation in ageing and the role of nutrition in Ageing Research Reviews

                                        Have feedback or a topic you'd like us to cover? Let us know here

                                        Episode transcripts are available here.

                                        1 hr 3 min

                                      About ZOE Science & Nutrition

                                      From the publisher's feed

                                      The world’s top scientists explain the latest health, nutrition, and gut health research and translate it into practical advice to improve your health & weight. Join ZOE Science & Nutrition,…

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