Brian is the Co-founder and CEO of Coinbase, a leading cryptocurrency company on a mission to increase economic freedom in the world. He is also a Co-founder of NewLimit, a biotechnology company working to radically extend human healthspan, and ResearchHub, which is aiming to accelerate the pace of scientific research. In 2018, Brian launched a nonprofit called GiveCrypto.org and signed the Giving Pledge, committing to give the majority of his wealth to charitable causes throughout his lifetime. Follow Brian on Twitter @brian_armstrong.

[2:18] - Brian's origin story

[9:33] - Reflections on his early career and how it prepared him to start Coinbase

[16:02] - Coinbase’s mission to increase economic freedom in the world, and why economic freedom is important

[23:34] - The challenges of building through crypto's hype cycles and scaling Coinbase at a rapid pace

[31:08] - An introduction to The RAPID Decision-Making Framework

[35:36] - How years of experience with remote employees helped Coinbase become a remote-first company

[45:24] - Repeatable innovation and the rationale for Coinbase’s 70/20/10 strategy for resource allocation

[54:34] - Coinbase’s contrarian decision to work with regulators from the beginning, and how it is increasingly leaning in on decentralization

[1:03:38] - Extending the human healthspan, an overview of NewLimit, and epigenetic reprogramming

[1:15:25] - Prioritizing "new media" over mainstream media

[1:21:12] - How ResearchHub can enable more open science and help build a bridge from scientific research to commercial products

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