Podcast Notes Playlist: Latest Episodes

#141 - AMA #18: Deep dive: sugar and sugar substitutes


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Drive with Dr. Peter Attia


Podcast Notes Key Takeaways
  • All sugars are not created equal
  • “Is glucose a sugar? Yes. Is fructose a sugar? Yes. Are they the same? Not even close.” – Peter Attia
  • Glucose & fructose have dramatically different metabolic effects
  • Fructose doesn’t stimulate insulin secretion the way glucose does but that doesn’t mean it’s healthy


Read the full notes @ podcastnotes.org



In this “Ask Me Anything” (AMA) episode, Peter and Bob talk all about sugar and sugar substitutes and provide a way to think about sugar consumption. The conversation begins by defining the various forms of sugar, delineating between added sugar and naturally occurring sugar, and describing the important variables that determine the potential for metabolic damage from consumption. They then take a dive deep into three main categories of sugar substitutes—non-nutritive sweeteners, alcohol sugars, and leaving allulose, in a class by itself—including the safety profile of each, impact on blood sugar and insulin, side-effects, taste preferences, and more. 

If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #18 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here

We discuss:

  • Delineating the various forms of “sugar” (2:00);
  • Added sugar vs. naturally occurring sugar (12:30);
  • Important variables related to sugar consumption: Density, volume, and velocity (17:00);
  • Alternatives to sugar: Non-nutritive sweeteners (22:30);
  • Alternatives to sugar: Alcohol sugars (34:15);
  • Alternatives to sugar: Allulose (39:00);
  • Contextualizing risk when it comes to sugar substitutes (45:00);
  • Why some people report feeling better when eliminating non-nutritive sweeteners from their diet (46:30);
  • The impact of sweetness—Cephalic insulin response and the metabolic drive to eat more (49:45); and
  • More.

Learn more: https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/ama18/ 

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