In Episode #184 of the PricePlow Podcast, Mike and Ben welcome back Ed Dosz, VP of Science Innovation at NutriScience Innovations, for a comprehensive exploration of ButyraGen, a revolutionary ingredient that generates butyrate directly in the small intestine. With butyrate serving as the primary fuel for colon cells while playing crucial roles in gut barrier function, immune modulation, and the gut-brain axis, Ed explains why this short-chain fatty acid has become one of the most important yet overlooked compounds in modern nutrition.

Ed Dosz Returns to Discuss ButyraGen: Solving the Modern Butyrate Crisis

The conversation tackles a fundamental problem facing modern gut health: the average American consumes only half the fiber needed for adequate butyrate production, and traditional prebiotics work only if you have the right gut bacteria. Ed details how ButyraGen's unique tributyrin-based formulation bypasses these limitations entirely through enzymatic action, delivering consistent butyrate generation regardless of microbiome status, age, or dietary habits.

Beyond the science of butyrate delivery, Ed shares insights from two published clinical studies demonstrating ButyraGen's real-world benefits, including significant reductions in belly pain and improvements in digestive quality of life. The discussion reveals particularly strong benefits for women and postmenopausal individuals, explores the fascinating gut-brain connection, and examines ButyraGen's potential applications in metabolic health, GLP-1 support, and beyond. This episode provides a comprehensive look at why direct butyrate generation represents the next evolution in digestive health supplementation.

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https://blog.priceplow.com/podcast/nutriscience-butyragen-184

Video: Ed Dosz Explains NutriScience's ButyraGen - Direct Butyrate Generation

https://www.youtube.com/watch?v=OnXrruuWyBE

Detailed Show Notes: The Science and Clinical Benefits of ButyraGen

(0:00) – Introduction and Reconnecting with Ed Dosz

(1:30) – Why Butyrate Matters: The Gut's Primary Fuel

(5:00) – The Modern Butyrate Deficit Crisis

(9:15) – Why Traditional Prebiotics Fall Short

(13:30) – Introducing ButyraGen: Direct Butyrate Generation

(18:45) – Dosing Efficiency: Small Dose, Massive Impact

(23:00) – Clinical Evidence: Two Published Human Studies

(28:15) – Women's Health: The Standout Clinical Finding

(33:30) – The Gut-Brain Axis and Future Research Directions

(38:45) – Metabolic Health and GLP-1 Connections

(43:15) – Practical Applications and Product Formulations

(48:30) – Quality Matters: Not All Tributyrin Is Created Equal

(53:00) – Stacking Strategies and Combination Recommendations

(57:45) – Safety, Tolerability, and Long-Term Use

(1:02:15) – Ed's Vision for the Future of Gut Health

(1:06:30) – Closing Thoughts and Contact Information

Where to Follow Ed Dosz and Learn More About ButyraGen

NutriScience Innovations: NutriScienceUSA.com

NutriScience on LinkedIn: LinkedIn.com/company/nutriscience-innovations-llc/

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