HVMN Podcast

Podcast Notes Key Takeaways

• Explosion of ketones as a field of study: (1) ketones are a potent but accessible intervention (legal, accessed through diet or exogenous; (2) scientists are living the lifestyle of what they’re studying which helps credibility, influence, experience
• “Ketones can rapidly change brain energy metabolism and the neuropharmacology of your brain in a way that’s neuroprotective and anti-seizure.” – Dr. Dom D’ Agostino
• There should be a duty to disseminate translatable, clear research to the public if funded through government means
• Ketones improve brain energy signaling metabolism, resilience, and enhance ability to maintain cognitive and physical performance in extreme environments – both environmental and physiologic
• Even within the ketogenic diet, there are many routes to go and options for exogenous ketones as supplement – like any diet, it needs to be personalized to your needs (a continuous glucose monitor can help)
• Starting in early middle age, natural uptake of glucose declines but ketone uptake is retained in the aging brain – ketones can circumvent glucose transporter and provide the energy for proper function
• The greatest effect of ketogenic diet on athletic performance will likely be over time where you’ll see improvements in recovery, epigenetic effects, anti-inflammatory effects
• Tip: consuming carbohydrates with exogenous ketones (such as a ketone salt, MCT) will minimize glycemic variability  
• “Completely excluding carbohydrates, fruit, and vegetables to the extent we do that with a clinical ketogenic diet is not optimal [for everyday]. A more diverse diet with plants, vegetables, different protein sources, with exogenous ketones would be more optimal.” – Dr. Dom D’Agostino
  • Instead, try a Mediterranean diet with exogenous ketones for supplementation with about 50-100g carbohydrates

Read the full notes @ podcastnotes.org



Dr. Dominic D’Agostino is an Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). Dr. Angela Poff is a Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida in Tampa, FL, and Co-Founder of Metabolic Health Initiative.   Dr. Latt Mansor and Geoff Woo met Dr. D’Agostino and Dr. Poff in person to talk about the state of the art of ketone research in 2022.   Key point topics and studies mentioned:

• Role of ketones and the future direction of ketone research in:
  • Athletic performance/ extreme environment
  • Mitochondrial protection in astronauts in space
  • Cancers
  • Metabolic psychiatry
  • Alzheimer’s and dementia

• Optimal blood ketone levels for health benefits
• Keto vs. carnivore vs. plant-based diets

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