Modern Thyroid and Wellness

43: Why Synthroid Isn’t Working – The Shocking Truth About T4, T3 & Thyroid Symptoms with McCall McPherson


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🎧 Episode Overview:

In this episode of Modern Thyroid Wellness, McCall McPherson unpacks one of the most common frustrations in thyroid care: why levothyroxine-based medications (like Synthroid) often leave patients feeling unwell, even when their labs look “normal.” Drawing from her own experience as a thyroid patient and her extensive clinical work, McCall explains the flawed assumption that every body seamlessly converts T4 into active T3—and why that’s simply not the case for many people.

She breaks down the three stages of levothyroxine treatment, reveals the gaps in standard thyroid testing, and explains how adding T3 therapy can change everything. This episode is a must-listen for anyone who feels unheard, dismissed, or stuck in their thyroid journey—and wants practical, actionable advice for regaining energy, balance, and hope.

Show Highlights:

✅ Why levothyroxine often isn’t enough—especially for patients who can’t convert T4 to T3 efficiently

✅ The hidden flaws in “normal” thyroid lab results

✅ The three stages of levothyroxine treatment every patient should understand

✅ The role of T3 therapy in restoring true thyroid balance

✅ How persistent symptoms like fatigue, brain fog, and weight gain are often overlooked

✅ Practical steps to discuss better testing and treatment options with your provider

✅ Empowering patients to advocate for themselves in their thyroid care

🔗 Links and Resources Mentioned:

🌐 Website:

https://www.modernthyroidclinic.com

📱 Social Media:

  • Instagram: @modernthyroidclinic
  • Instagram (McCall): @mccallmcpherson

📚 Learn More:

  • Schedule a Consultation with McCall
  • Thyroid Resource Library

...more
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Modern Thyroid and WellnessBy McCall McPherson, PA-C

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