While evolution is often thought to be conducive to perfect adaptation, there are plenty of reasons why we never get there. 

Laurence D. Hurst is a professor of evolutionary genetics in the Milner Centre for Evolution at the University of Bath. His book, The Evolution of Imperfection: The Science of Why We Aren’t and Can’t Be Perfect is an expansive look into the imperfections of the human genome and why humans seem to be predisposed to so much bad genetic luck. 

Laurence and Greg explore the evolutionary constraints that lead to imperfections, how population size affects mutation rates, the advancements in gene therapy, and why imperfection could be key to a deeper understanding of evolution. 

*unSILOed Podcast is produced by University FM.*

Episode Quotes:

Why humans have such bad genetic luck

07:13: We have good reason to think that humans are far from being as fit as they might be. We have a very high mutation rate. We've got one of the highest mutation rates going, for example, and most mutations are deleterious. Most of the time, five to 10% of us will have a rare genetic disorder, for example. And we could be better. We could be a lot, lot, lot better.

Medicine is anti-evolution

47:17: Medicine is anti-evolution. Evolution is why we keep on having these genetic diseases, and medicine goes, well, you might have them, but we are going to stop them having their effects.

Childbirth is more dangerous than the most dangerous job in America

12:13: Childbirth is, for humans, a spectacularly dangerous pursuit. There was a lovely survey done by Forbes Magazine of America's most dangerous jobs, and it turns out nothing comes close to childbirth. Childbirth is an order of magnitude more dangerous than America's most dangerous job.

Show Links:

Recommended Resources:

• 10 Most Dangerous U.S. Careers Heading Into 2025, Study Reveals | Forbes
• Nearly neutral theory of molecular evolution
• He Jiankui

Guest Profile:

• Faculty Profile at University of Bath
• Professional Website
• Milner Centre Profile on X

Guest Work:

• The Evolution of Imperfection: The Science of Why We Aren’t and Can’t Be Perfect

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