“All good scientists are skeptics.” — Dr. Anthony Pearson
The Skeptical Cardiologist on Substack is HERE
American Heart Association 2026 Guidelines is HERE
MESA CAC Database is HERE In this episode, I’m joined by Dr. Anthony Pearson, the cardiologist behind The Skeptical Cardiologist newsletter on Substack, for a practical conversation about what women over 50 need to know now about heart health. We talk about the new cholesterol guidelines, why personalized risk assessment matters, and why tests like CAC, Lp(a), and ApoB can reveal much more than a standard lipid panel alone.
Why heart disease is still the number one killer of women
The biggest blind spots women over 50 still have about heart risk
What changed in the new cholesterol guidelines
Why earlier detection and more personalized risk assessment matter
Why CAC, Lp(a), and ApoB are getting more attention
What those tests can reveal that a standard lipid panel may miss
Why statins still matter, despite all the noise around them
When non-statin options may make sense
The role of inflammation in cardiovascular disease
The lifestyle habits that still matter most for prevention A few key takeaways from this conversation
You can feel healthy, exercise regularly, eat well, and still have hidden cardiovascular risk
A standard cholesterol panel does not always tell the full story
CAC, Lp(a), and ApoB can help create a more complete and individualized picture of risk
High Lp(a) is inherited and is important to know about, even before a specific drug is widely available
ApoB is a more precise marker of atherogenic particles and can add valuable information to routine testing
Statins remain an important, well-studied first-line tool for many people
Prevention works best when you start earlier, not after a cardiac event
Cardio exercise, strength training, and maintaining a healthy body composition all matter Subscribe to AGE BETTER so you never miss an episode!