What if an AI could run centuries of aging experiments in a year? Dr. Daniel Ives, CEO of Shift Bioscience, explains how his team used a virtual cell to discover SB000 — a single gene that matches Yamanaka factor rejuvenation without cancer risk.

CHAPTERS:
00:00 — Centuries of experiments in a year
02:03 — Daniel's journey: physics → Aubrey de Grey
10:08 — The epigenetic clock breakthrough
12:09 — The 13 mitochondrial genes
20:09 — Yamanaka factors (OSKM) explained
22:10 — Partial reprogramming: the weekend analogy
24:11 — The cancer risk problem
26:11 — AI virtual cell: how it works
32:12 — AI-driven dark labs
40:16 — Single-gene interventions
42:17 — Shift's discovery: genes that reverse aging
50:19 — Animal testing begins
62:20 — Hearing loss: the unexpected aging connection
66:21 — Rapamycin reverses hearing loss in animals
78:25 — N=1 medicine and wearables
84:26 — Closing

REFERENCES:

Shift Bioscience: shiftbioscience.com

Partial Reprogramming (Nature Comms, 2024): Nature

Epigenetic Clock (Frontiers in Aging, 2024): Frontiers

GUEST: Dr. Daniel Ives, PhD — CEO, Shift Bioscience, Cambridge UK
HOST: Dr. Robert Lufkin MD | robertlufkinmd.com⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!

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