The most played episodes among Podcast App listeners.

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   Number 1: 863: Turning Back Time: The Secrets Behind Anti-Aging Skincare

   Wrinkles, Aging, and Youthfulness - In the quest for youthful, radiant skin, a range of cutting-edge treatments and therapies has emerged to combat the signs of aging. From lymphatic massage, which aids in detoxification and reducing inflammation, to LED therapy that stimulates collagen production and reduces fine lines, and finally, PRP treatments with microneedling to enhance skin texture and elasticity — these innovative approaches offer promising solutions for those seeking to turn back the clock on aging skin. Join us as we delve into the science behind these treatments and discover how they can help you achieve a more youthful and vibrant appearance.

   September 04, 2026·17min
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   Number 2: 862: Reversing Cellular Senescence: GPX4, Ferroptosis, and Adaptive Senotherapeutics with Dr. Frederick Beddingfield

   Are you fascinated by the molecular science of aging and senescence? In this episode of Beauty Bytes, I am joined by Dr. Frederick Beddingfield III, the CEO of Rubedo Life Sciences, a physician-scientist, and a former senior leader at Allergan. We focus on the cutting edge of longevity and how Rubedo is developing adaptive senotherapeutics to reverse cellular aging and extend healthspan. Dr. Beddingfield explains the science behind their lead drug, RLS 1496, which targets the enzyme glutathione peroxidase 4 (GPX4) to regulate ferroptosis, an iron-dependent cell death pathway. We discuss how this drug not only eliminates toxic senescent cells but also acts as a "redox reset" for aged cells, reducing their biological age by improving mitochondrial function and autophagy. We also explore their groundbreaking human clinical trials, which demonstrated a 50% reduction in precancerous actinic keratoses in just four weeks without causing skin irritation. Plus, Dr. Beddingfield shares his personal biohacking stack, including low-dose rapamycin, fisetin, and quercetin. Guest Information: Dr. Frederick Beddingfield III is the CEO of Rubedo Life Sciences. You can learn more about their clinical trials at rubedolifesciences.com or follow him on Instagram and LinkedIn at @FrederickBeddingfield.

   September 02, 2026·34min
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   Number 3: 861: Melatonin 101: Anxiety, Sun Exposure, and Sleep Disorders

   Earplugs, blindfolds, or milk before bed time-if these can’t help you get a good night’s rest, you might turn to for help. But is this really the best way to solve your sleeping issues? That said, you might want to understand the mechanism behind melatonin before jumping into any impulsive decisions. Tune into this week’s Five Minutes Friday to discover the secrets behind melatonin on the market!

   August 29, 2026·12min
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   Number 4: 858: Why ADHD Feels Different for Women: Hormones & the Brain with Dr. Jolene Brighten

   Are you wondering why ADHD can feel so different for women, especially during perimenopause and other major hormonal transitions? In this episode of Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon, I am joined by Dr. Jolene Brighten, a women’s health expert, author, and hormone specialist, to break down the complex relationship between ADHD, estrogen, dopamine, brain energy, and inflammation. Dr. Brighten explains why ADHD is not simply an inability to focus, but a disorder of attention regulation and executive function, and why symptoms can become more noticeable as hormones begin to fluctuate. We dive into the role of estrogen in dopamine, serotonin, acetylcholine, and norepinephrine signaling, as well as the emerging connection between ADHD and mitochondrial dysfunction. Dr. Brighten also discusses why perimenopause can intensify brain fog, forgetfulness, emotional reactivity, sleep disruption, and difficulty concentrating, and how neuroinflammation and declining brain energy may contribute. We also explore practical strategies for supporting the ADHD brain, including exercise, protein intake, blood sugar regulation, sleep optimization, magnesium, creatine, saffron, and other nutrients that may support cognitive function. From GLP-1 medications and thyroid health to stress, sleep, and lifestyle habits, this conversation looks at ADHD through a whole-body lens and gives women a clearer understanding of why their brain may feel different at different stages of life. Guest Information: Dr. Jolene Brighten is a women’s health expert, author, and host of The Dr. Brighten Show. Her upcoming book, ADHD in Women, explores how female hormones influence ADHD symptoms across the lifespan. You can find her online at @DrJoleneBrighten and learn more about her work at drbrighten.com.

   August 18, 2026·50min
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   Number 5: 865: Summer Skin Recovery: Repairing Your Barrier for Fall

   Summer heat takes a toll on your skin. In this week’s podcast, we’re talking dryness, irritation, and the breakdown of your lipid barrier. This natural barrier is your shield against environmental stressors, and when it’s disrupted, inflammation follows. As the season shifts, it’s the perfect time to repair and restore. We’ll cover why ceramide-rich moisturizers matter, how hydrating soaks help replenish, and why it’s smart to ease up on exfoliation. Plus, we share tips on diet, recovery treatments, and why end-of-summer peels set you up for glowing, resilient skin heading into fall.

   September 11, 2026·12min
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