David Krantz and I talk about how genetics affect the metabolism of cannabis (nutrigenomics) and the resulting impact of cannabis use on our epigenetic health. Furthermore, we reach into a discussion on how the same framework of understanding applies to our metabolism of psychedelics and the potential future of a genome-specific screening program for psychedelic-assisted psychotherapy.

--LINKS-- For links to David's work, full show notes, and to watch this episode in video, head to Https://bit.ly/ATTMind111 **Full Topics Breakdown Below   --- SUPPORT THIS PODCAST —  Patreon: https://patreon.com/jameswjesso Donations: https://www.paypal.me/JWJesso Merchandise: https://www.jameswjesso.com/shop/ More options: https://www.jameswjesso.com/support/   Sponsor: FORMULA Nootropics https://www.jameswjesso.com/formula Use promo code "jesso" to get 20% off your first order.   Newsletter: https://www.jameswjesso.com/newsletter ------------- Episode Breakdown

• a general rundown of nutritional genomics and its application in understanding biology
• the profound health issues David faced that brought him into nutritional genomics
• (special note about the value of understanding polyvagal theory)
• the failure of the pre-packed dietary approach, be it veganism, paleo, or low-carb
• the endocannabinoid system
• the genetic differences of cannabis metabolism between different people
• why some people can “smoke weed every day” and make millions, and others can’t get off the couch
• how cannabis effects working memory differently in different genetic predispositions in each people based on baseline dopamine levels
• how our brain hides from itself
• the phenomena of “used to smoke all the time without issues then all of a sudden cannabis creates anxiety and paranoia”
• epigenetics and how cannabis changes how our genes express
• the genetic variant that increases the chances of developing cannabis-induced psychosis
• genetic profiling as a screening platform to understand what medical intervention would be most helpful for specific people
• the institutional complications that might prevent the introduction of genetic-specific medical care into the medical infrastructure
• how these ideas fit inside the modern context of the climate crisis
• how do genetic profiles influence dose-response differences with psychedelics
• speculating on the long term epigenetic impact of psilocybin use
• speculating on the long term epigenetic impact of therapeutic/healing work

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*** Big thanks to my patrons on Pateron for helping keep this podcast alive! Especially, Thomas & Melanie H, Clea S, Steven B, James R, Dean H, Joe A, Andy D, Stephen B, Ian C, David W, Don J, Yvett FC, Ann-Madeleine, Dima B, Chuck W & Cornelius Phlegmbottom

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