Everybody knows someone battling cancer. Fusobacterium nucleatum is an oral anaerobe that trans-locates to other areas of the body. It negatively impacts gut health in a number of ways including contributing to Irritable Bowel Syndrome.

 Initially it was found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcomes. It is being widely studied and found to be associated with a growing number of cancers. Recent research is showing that this oral pathogen may induce resistance to several chemotherapy drugs.  The good news is that we can test for it and treat it relatively simply. This is information that can increase your vitality, improve your relationships, and take the stress out of being healthy!

References:

Fusobacterium nucleatum confers chemoresistance by modulating autophagy in esophageal squamous cell carcinoma (December, 2020)
https://www.nature.com/articles/s41416-020-01198-5 

Fusobacterium nucleatum:  a new player in regulation of cancer development and therapeutic response (May, 2022)  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255244/  

Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer (January, 2019) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327560/ 

Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression (June, 2020)
https://www.nature.com/articles/s41467-020-16967-2 

Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer (February, 2023) https://www.cell.com/trends/microbiology/fulltext/S0966-842X(22)00222-0 

The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences?  A systematic review  (April, 2021) https://pubmed.ncbi.nlm.nih.gov/33823861/ 

Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?  (December, 2020) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761398/ 

More Than Just a Periodontal Pathogen – the Research Progress on Fusobacterium nucleatum (February, 2022)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8851061/ 

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