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Confession: Open-minded medicine must still be evidence-based medicine.
Did the FDA just approve BPC-157 and other popular peptides? Not exactly and that distinction matters.
Following a closely watched FDA advisory committee meeting, headlines and social media posts began suggesting that peptides such as BPC-157, TB-500, KPV, MOTS-c, Epitalon, and Semax had been "approved" or "unbanned."
Let's be clear: An advisory committee recommendation is not the same thing as FDA approval, proven effectiveness, or established long-term safety.
In this episode of Confessions of a Male Gynecologist, Americas Holistic Gynecologist, Dr. Shawn Tassone explains what the recent FDA peptide vote actually means, what could happen next, and why patients and practitioners should be careful about confusing expanded compounding access with scientific validation.
Peptides are increasingly promoted online for injury recovery, inflammation, gut health, mitochondrial function, metabolism, sleep, longevity, cognitive performance, this list goes on...
Some have interesting biological mechanisms and promising preliminary research, but many of the claims being made online extend far beyond the available human evidence.
In this episode Dr. Tassone examines:
KPV: Its proposed anti-inflammatory benefits and the lack of meaningful clinical studies in humans.
TB-500: Why it is frequently confused with thymosin beta-4 and why the distinction matters when evaluating research.
MOTS-c: The growing interest in its potential mitochondrial and metabolic effects and the questions that remain unanswered.
Epitalon: Claims involving sleep, longevity, and anti-aging versus the strength of the available evidence.
Semax: Why having more reported human exposure does not automatically mean the research meets modern clinical standards.
The FDA's 503A Bulk List: What pharmacy compounding access means and what it does not mean.
Peptide Marketing: How experimental therapies can begin sounding proven long before adequate safety and effectiveness data exist.
Promising mechanisms deserve research, patient experiences can help generate better questions, but neither should be used as a replacement for rigorous human trials, reliable manufacturing standards, appropriate medical oversight, and honest conversations about uncertainty.
Before assuming that a favorable committee vote means a peptide is now FDA approved, safe, or clinically proven, listen to this episode for the full context, share this episode with someone considering peptide therapy, and leave a rating or review to help more people find evidence-based conversations about their health and hormones!
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Please contact the clinic directly at (512) 956- 0296 with all scheduling inquiries.
Purchase Dr. Tassone's Best-Selling Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Discover Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
Confession: Just because your doctor ignored you doesn't mean the wellness industry automatically deserves your credit card.
Women are finally talking about hormones, perimenopause, menopause, estrogen, progesterone, testosterone, libido, fatigue, weight gain, brain fog, and hormone replacement therapy, and that is a good thing.
But now that women's hormones are trending, everyone seems to have something to sell: a test, a pellet, a peptide, a supplement stack, a detox, or a one-size-fits-all "optimization" protocol.
In this episode, America's Holistic Gynecologist breaks down one of the biggest questions women are asking right now: Are Your Hormones Actually Broken… or Are You Being Sold a Problem?
Dr. Tassone discusses the difference between real hormone dysfunction, normal hormonal transition, medical dismissal, non-hormonal health issues, and wellness marketing disguised as personalized care. He explains why "normal labs" do not always mean everything is fine, why symptoms matter but are not a diagnosis by themselves, and why more testing, more hormones, or more supplements do not always equal better medicine.
This episode also dives into some of the most common hormone and wellness traps women are falling into, including testosterone hype, hormone pellets, "bioidentical" marketing, advanced hormone testing, peptides, NAD, supplement stacking, and fear-based wellness messaging.
If you have ever been told your labs are normal but still knew something felt off, or if you have felt overwhelmed by conflicting hormone advice online, this episode will help you ask better questions, spot red flags, understand what thoughtful hormone care should actually look like, and separate real hormone care from hormone marketing.
In This Episode, Dr. Tassone Covers:
Why women are being caught between medical dismissal and wellness marketing
The 4 reasons women may feel "hormonal"
Why symptoms matter, but symptoms alone are not always a diagnosis
Why normal labs should not automatically end the conversation
The difference between real hormone care and a product-based protocol
Common red flags in hormone clinics, wellness programs, and online hormone advice
Why testosterone can be helpful for some women, but is not a magic fix
The problem with overselling hormone pellets as "natural" or universally safer
Why a $700 hormone test is not the same thing as a treatment plan
How peptides, NAD, longevity trends, and supplement stacks can be overmarketed
What informed consent should look like in hormone care
How women can tell if they are being educated, dismissed, or sold to
What personalized hormone care should actually include
Every woman receives the same protocol
The answer is always the product, hormone, test, or supplement being sold
Fear is used before physiology is explained
Risks, side effects, contraindications, and alternatives are not discussed
Hormone testing is used to confuse instead of clarify
Symptoms are blamed on one single hormone or pathway
The provider promises one thing will fix everything
There is no thoughtful follow-up or dose adjustment
You leave feeling broken, scared, or pressured instead of informed
A detailed medical history
A clear symptom timeline
Review of medications, supplements, and lifestyle factors
Menstrual, perimenopause, menopause, or postmenopause status
Thyroid, metabolic, inflammatory, adrenal, and nutritional context
Thoughtful lab testing when clinically appropriate
A risk-benefit conversation
Discussion of alternatives
Individualized dosing
Ongoing follow-up
Adjustments based on symptoms, labs, and response to treatment
If this episode helped you understand the difference between real hormone care and wellness marketing, share it with a woman who has been told her labs are normal but still knows something feels off.
For more honest conversations about women's health, hormones, perimenopause, menopause, and medical misinformation, subscribe to the podcast and follow Dr. Tassone on social for daily updates!
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Please contact the clinic directly at (512) 956- 0296 with all scheduling inquiries.
Purchase Dr. Tassone's Best-Selling Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Discover Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
What does your gut have to do with your hormones, mood, weight, and menopause symptoms?
Potentially more than you realize.
In this episode of Confessions of a Male Gynecologist, Dr. Shawn Tassone sits down with Cynthia Thurlow, NP, to explore the complex relationship between gut health, hormonal changes, nutrition, and weight management during perimenopause, menopause, and beyond.
Cynthia shares how a personal health crisis changed the direction of her work and led her to take a deeper look at the gut microbiome. Together, she and Dr. Tassone discuss why digestive symptoms often change during midlife, how chronic stress can disrupt the gut, and why weight-loss resistance is rarely caused by one single issue.
They also address some of the most common nutrition mistakes women make, including under-eating protein, relying heavily on processed foods, consuming more carbohydrates than their bodies tolerate well, and overlooking the impact of alcohol on sleep, metabolism, and weight-loss goals.
You'll also hear their perspectives on restrictive diets, gut testing, supplements, fermented foods, plant diversity, and the importance of choosing high-quality dietary fats.
This conversation is not about following another rigid wellness protocol. It is about understanding how your gut, hormones, nutrition, stress, and lifestyle work together—and making informed choices that support your health during midlife.
In this episode, you'll learn:Gut symptoms, hormonal changes, and weight concerns should not automatically be dismissed as an unavoidable part of aging. By looking at the full picture, women can better understand what their bodies need and make more sustainable decisions for their long-term health.
Listen now, share this episode with a woman navigating midlife, and subscribe to Confessions of a Male Gynecologist for honest, evidence-informed conversations about women's health, hormones, menopause, and wellness.
About Cynthia Thurlow, NP
Cynthia Thurlow is a nurse practitioner, host of the Everyday Wellness podcast, author and international speaker, with over 15 million views for her second TEDx talk (Intermittent Fasting: Transformational Technique). With over 25 years of experience in health and wellness, Cynthia is a globally recognized expert in perimenopause/menopause and intermittent fasting, and has been featured on ABC, FOX5, KTLA, CW, Medium, Entrepreneur, and The Megyn Kelly Show. Her mission is to help empower women to live their most optimal lives in perimenopause and beyond.
Connect with Cynthia Thurlow
Instagram | @cynthia_thurlow_
Listen to the Everyday Wellness Podcast
Purchase The Menopause Gut by Cynthia Thurlow, NP
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Dr. Tassone's Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Learn Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
For years, women were told their symptoms were "all in their head." Fatigue, brain fog, irregular periods, hot flashes, vaginal dryness, anxiety, insomnia, weight changes — dismissed, minimized, or blamed on stress.
But now the pendulum has swung hard in the opposite direction.
Spend five minutes on Instagram or TikTok and you'll likely be told your cortisol is too high, your estrogen is too high, your progesterone is too low, your testosterone needs optimizing, your gut is destroying your hormones, and every symptom you have is proof of a hormone imbalance.
So which is it?
In this episode of Confessions of a Male Gynecologist, Dr. Shawn Tassone breaks down the growing trend of "hormone marketing" and why women should be cautious when influencers, health coaches, and even providers outside their scope claim to have the answer after a 30-second reel.
Dr. Tassone makes one thing clear: hormones absolutely matter. Hormone imbalance is real. Perimenopause, menopause, thyroid dysfunction, low testosterone, estrogen imbalance, and progesterone issues can deeply affect a woman's quality of life, but not every symptom is automatically hormonal — and women deserve more than fear-based marketing, supplement funnels, cortisol cocktails, and oversimplified protocols.
This episode is a reminder that validation should be the beginning of a medical evaluation, not the end.
In this episode, you will learn:Your symptoms are real — but they deserve a real evaluation.
Hormones may be part of the answer, but they are not always the entire answer. The goal is not to convince every woman she needs hormones. The goal is to help women understand their bodies with evidence, compassion, and common sense.
Listen if you've ever wondered:Dr. Tassone is licensed in 48 states and works with women across the country through in-person and virtual care, with the exception of Massachusetts and Alaska. To schedule an appointment, call: 512-956-0296
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Dr. Tassone's Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Learn Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
Irritable Bowel Syndrome, or IBS, is one of the most common digestive diagnoses women receive — but what if it's not the full story?
In this episode, Dr. Shawn Tassone sits down with Dr. Izabella Wentz to unpack the deeper root causes behind IBS, gut symptoms, food sensitivities, and the connection between digestive health and autoimmune disease.
Dr. Wentz shares her own personal journey with IBS and Hashimoto's, including how conventional medicine often stops at symptom management instead of asking why the gut is struggling in the first place. Together, Dr. Tassone and Dr. Wentz explore what "normal" digestion should actually look like, why IBS is frequently diagnosed based on symptoms alone, and why many women are left searching for answers when standard treatments don't work.
This conversation dives into the role of dietary triggers like gluten, dairy, and food additives, as well as nutritional deficiencies such as magnesium and zinc that may contribute to bloating, constipation, diarrhea, discomfort, and ongoing digestive issues. Dr. Wentz also explains how intestinal permeability — often referred to as "leaky gut" — may play a role in autoimmune conditions and why infections like SIBO and H. pylori are commonly found in women with IBS symptoms.
You'll also hear why medications, environmental toxins, and hidden inflammatory triggers may worsen gut health, plus how functional testing can help uncover what is actually driving symptoms instead of masking them.
Whether you've been diagnosed with IBS, struggle with bloating or unpredictable digestion, have Hashimoto's or another autoimmune condition, or feel like your symptoms have been dismissed as "normal," this episode offers a more empowering way to understand your gut.
In This Episode, You'll Learn:If you've been told your gut symptoms are "just IBS" but you still don't feel better, this episode is for you. Listen now to learn what may be driving your digestive symptoms — and what questions to ask next.
About Dr. Izabella Wentz, Pharm.D., FASCP
Dr. Izabella Wentz, Pharm.D., FASCP, is a clinical pharmacist, functional medicine expert, and New York Times bestselling author specializing in Hashimoto's, thyroid health, adrenal health, and root-cause approaches to chronic symptoms.
After being diagnosed with Hashimoto's Thyroiditis in 2009, Dr. Wentz dedicated her work to helping patients uncover the lifestyle, nutritional, environmental, and functional medicine factors that contribute to autoimmune thyroid disease and related symptoms.
She is the author of Hashimoto's Thyroiditis, Hashimoto's Protocol, Hashimoto's Food Pharmacology, and Adrenal Transformation Protocol, and the creator of the documentary series The Thyroid Secret. Her work has been featured in The New York Times, The Wall Street Journal, USA Today, Fox News, and MindBodyGreen.
Connect with Dr. Wentz
Support your gut health journey with the IBS Book (available now!)
Get the Adrenal Transformation Protocol book Learn more about the Hashimoto's Food Pharmacology cookbook Learn more about the Hashimoto's Protocol book Learn more about the Root Cause book Take the Hashimoto's Self-Management Program Learn more about supplements Own your copy of The Thyroid Secret
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Dr. Tassone's Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Learn Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
In this episode of Confessions of a Male Gynecologist, Dr. Shawn Tassone takes on one of the most confusing and controversial areas in women's health: hormone therapy.
From menopause myths and fear-based medicine to wellness industry scams and influencer-driven misinformation, Dr. Tassone breaks down what women need to know before blindly following advice online — or accepting outdated medical opinions that don't match their symptoms.
For decades, women have been told to fear estrogen, ignore symptoms, accept "normal labs," or believe that menopause is simply something they have to suffer through. But the truth is more nuanced. Hormone therapy can be life-changing when it is personalized, monitored, and based on the individual — not just a protocol, a trend, or a sales pitch.
Dr. Tassone discusses the lasting impact of the Women's Health Initiative study, the rise of bioidentical hormone marketing, the misuse of testosterone in women, and why both conventional medicine and functional medicine can fall short when they stop treating the person in front of them.
This episode is a call for critical thinking in women's health — because women deserve education, not fear. Options, not shame. And care that goes deeper than "your labs are normal."
In This Episode, Dr. Tassone Covers:Hormone therapy is not one-size-fits-all. The goal is not to chase perfect lab numbers, follow a trending protocol, or fear estrogen because of outdated headlines. The goal is to treat the individual woman — her symptoms, history, risks, goals, and quality of life.
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Dr. Tassone's Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Learn Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
Artificial intelligence and robotic surgery are no longer "future medicine" — they're already changing the way physicians diagnose, operate, and care for patients.
In this episode of Confessions of a Male Gynecologist, Dr. Shawn Tassone sits down with Dr. Sanjeev Kumar, a gynecologic oncologist, to discuss how AI, robotics, genetic testing, and personalized medicine are transforming women's healthcare — especially in gynecologic oncology.
From the evolution of robotic surgery to the growing role of AI in pathology, diagnostics, and cancer detection, this conversation breaks down what these advancements mean for both physicians and patients. Dr. Tassone and Dr. Kumar explore the benefits, limitations, and future possibilities of technology in medicine, while also asking the bigger question: how do we use innovation without losing the human side of healthcare?
This episode is a must-listen for anyone interested in the future of medicine, women's health, cancer care, and how emerging technology may change the patient experience.
In This Episode, We Cover:Connect with Dr. Sanjeev Kumar
Media Profile | https://www.guestsonair.com/profile/dr-sanjeev-kumar LinkedIn | https://www.linkedin.com/in/sanjeev-kumar-md-34781a84/ Website | https://www.drsanjeevkumarsurgeon.com/
About Dr. Sanjeev Kumar
Dr. Sanjeev Kumar is a gynecologic oncologist and robotic pelvic surgeon whose career has been defined by technical excellence, intellectual rigor, and a clear sense of purpose. Born in India, he completed medical school there, went on to train in England and Wales through the MRCS, and later continued his surgical education in the United States, ultimately building a career that placed him among the country's leading figures in robotic pelvic surgery. That path reflects a career shaped by discipline, international training, and an enduring commitment to surgical mastery. His work sits at the intersection of some of the most demanding questions in medicine: women's cancers, advanced pelvic surgery, and the evolving role of robotics and AI in the operating room. He entered robotic surgery in 2006, early enough to help shape the field rather than merely follow it, and in 2017 was reported as the eighth busiest robotic pelvic surgeon in the United States by volume. That distinction matters not as a statistic, but as evidence of depth, repetition, and mastery in one of surgery's most exacting specialties.
Episode Resources:
Work with Dr. Tassone | Tassone Advanced Gynecology
Dr. Tassone's Book | The Hormone Balance Bible
Dr. Tassone's Integrative Hormonal Archetype Quiz | Learn Your Hormonal Archetype
Medical Disclaimer This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
In this insightful interview, Dr. Shawn Tassone is joined by OBGYN PA, Nikki Sapiro Vinckier, to discuss the broken state of reproductive healthcare, its historical roots, and how women can advocate for better care. She shares personal stories, systemic issues, and practical advice for patients and clinicians alike including information about her new book, We Deserve More.
Episode Highlights:
About Nikki Sapiro Vinckier:
Nikki Sapiro Vinckier, PA-C, is an OB/GYN Physician Assistant, reproductive health advocate, and founder of Take Back Trust, a national platform helping people navigate their reproductive healthcare with clarity and confidence. After more than a decade in clinical medicine, she now works at the intersection of medicine, media, and movement, creating tools, education, and storytelling that empower patients to advocate for themselves in a changing healthcare landscape. Her work has reached millions across digital platforms, where she is known for her clear, compassionate, and deeply human approach to reproductive care. We Deserve More is her debut book.
Episode Resources:
Dr. Tassone's Free Women's Health Journal Club | Dr. T's Evidence Edit
Dr. Shawn Tassone's Practice | Tassone Advanced Gynecology
Dr. Shawn Tassone's Book | The Hormone Balance Bible
Dr. Shawn Tassone's Integrative Hormonal Mapping System | Hormonal Archetype Quiz
Medical Disclaimer
This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
Women are constantly being flooded with viral health advice online — especially when it comes to menopause symptoms like brain fog, fatigue, anxiety, and inflammation. But how much of it is actually backed by science?
In this episode, Dr. Shawn Tassone breaks down the growing social media trend claiming that antihistamines like Pepsid may help relieve menopause brain fog and other hormonal symptoms. Dr. Tassone explores where these claims originated, the role histamines may play in the body, how estrogen can influence mast cells and histamine release, and why women are searching for alternative answers in the first place.
You'll also hear an honest conversation about misinformation in women's health, the dangers of turning one case report into medical advice, and why evidence-based medicine still matters — even in the age of TikTok wellness trends.
If you've ever struggled with menopause brain fog, felt dismissed by conventional healthcare, or wondered whether viral hormone "hacks" actually work, this episode is for you.
In This Episode, Dr. Tassone Discusses:Episode Resources:
Dr. Tassone's Free Women's Health Journal Club | Dr. T's Evidence Edit
Dr. Shawn Tassone's Practice | Tassone Advanced Gynecology
Dr. Shawn Tassone's Book | The Hormone Balance Bible
Dr. Shawn Tassone's Integrative Hormonal Mapping System | Hormonal Archetype Quiz
Medical Disclaimer
This podcast and website represent the opinions of Dr. Shawn Tassone and his guests. The content here should not be taken as medical advice and is for informational purposes only. Because each person is so unique, please consult your health care professional for any medical questions.
Confession #163: I can't emotionally, spiritually, psychologically, or physically bring myself to recommend hormone pellets for women.
And after years of seeing the complications in clinical practice… I stand by that.
Hormone pellets are small implants placed under the skin that release hormones like testosterone or estrogen over the course of 3-6 months. They're often marketed as the "easy," or "best" form of hormone replacement therapy for women, but in my experience, as a Double Board-Certified OBGYN and Integrative Medicine physician, many women are never told the full story before getting them.
I've seen patients first-hand struggle with: • Hormone levels that spike too high • Hair loss and acne • Mood changes and anxiety • Irregular absorption • Testosterone side effects that can become permanent • Feeling "stuck" once the pellets are inserted
And yes… I tried pellets myself years ago. It was one of the worst experiences I've personally had with hormone therapy.
The reality is: there are often more personalized and adjustable ways to use bioidentical hormones, including topical creams, troches, rapid dissolve tablets, and other delivery methods that allow dosing changes without locking someone into months of exposure.
In this episode, I break down: • How hormone pellets actually work • Why pellets can create unstable hormone patterns • The biggest risks women are rarely warned about • Why pellet therapy has become such a profitable business model • The problem with protocol-driven hormone care • Why individualized treatment matters in women's health • What to do if you already have pellets and want to transition off safely • Bioidentical hormones vs synthetic hormones explained
The truth is: Hormone replacement therapy should never be one-size-fits-all.
Women deserve personalized care, informed consent, evidence-based medicine, and treatment plans that can adapt as their bodies change.
If you've ever been told pellets are your ONLY option… this episode is for you.
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