Podcast Notes

• It’s unclear how long antibodies from SARS-CoV-2 last and whether they confer protection from future infection
• Ability of antibodies to neutralize virus remains uncertain
• Non-heritable traits such as nutrition, sleep, cross-immunity, biological age, and microbiome seem to play a larger role in variation of virus symptoms as compared to genetics
• Men and women are equally likely to get COVID-19 but men are more likely to die from it
• “Deficiencies or insufficiencies in micronutrients negatively affect immune function and can decrease resistance to infections.” – Rhonda Patrick, PhD.

Read the full notes @ podcastnotes.org

This is a continuation of the last episode where Dr. Patrick took questions from newsletter subscribers around the on-going pandemic and tried to add value by talking about some of the recent research, among other things.

Some of the topics that came up as a result of the questions submitted include:

• 00:04:03 - Data surrounding SARS-CoV-2 duration
• 00:06:37 - SARS-CoV-2 and potential immunity
• 00:11:35 - Some of the main factors known to play a role in immune variation
• 00:12:05 - What role genetics may play in immune function
• 00:14:27 - How previous viral exposure regulates immunity
• 00:15:05 - What cross immunity is and how it may be relevant for SARS-CoV-2
• 00:19:46 - Antibody-dependent enhancement and SARS-CoV-2 relevance
• 00:21:50 - How sleep is a key regulator of immune function
• 00:23:44 - Microbiome composition and immune function
• 00:28:31 - The differential effects of exercise intensity and duration on immune regulation
• 00:35:00 - How specific micronutrient inadequacies may promote immune dysregulation
• 00:47:20 - The effect of sex hormones on immune function
• 00:48:55 - How biological age age may play a role in immune regulation
• 00:49:46 - Controversy surrounding hypertension drugs such as ACE inhibitors and COVID-19
• 00:53:15 - ARDS and long-term lung damage

Get our detailed summary, timeline, references and more on the FoundMyFitness episode page.

This episode mentions a number of genetic polymorphisms that affect viral entry into the host cell, viral replication, host immune response ranging from cytokine production to viral-induced inflammation, SNPs that affect vitamin D levels and more. If you have used any consumer-based genetic testing services like 23andMe or Ancestry DNA we have a free viral report with these SNPs that you can check out.

• Learn more about this free report by clicking here.

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