Dr Karan Explores

Do we really need to be so worried about our testosterone levels? And is it really the solution to all of our health problems?

In this episode I speak to reproductive health specialist Dr Channa Jayasena. We discuss testosterone, the myths around it and the latest in reproductive science!

Timestamps

(0:00) Intro - Are we really facing a low testosterone crisis?

(02:35) Why testosterone prescriptions have increased by 135%

(08:17) What your testosterone levels reveal about your overall health

(12:04) Testosterone, masculinity and the male body image crisis

(17:56) What are the real symptoms of low testosterone?

(21:26) Should healthy men get their testosterone tested?

(23:05) Does testosterone really decline as we age?

(26:25) What other factors can lower testosterone?

(30:31) Does testosterone replacement therapy mask underlying health problems?

(34:53) The dangers of peptides and hormone cocktails

(36:12) Can you naturally boost your testosterone?

(38:31) The health risks of taking testosterone you don't need

(40:06) Why testosterone levels don't tell you about sperm health

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

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Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

What role does gut health have to play in the menopause? 

In this episode I speak to Cynthia Thurlow, author of The Menopause Gut, who explains how a woman’s microbiome shifts during menopause - and why understanding this can dramatically improve health outcomes.

Timestamps

(0:00) Intro - Why gut health becomes so important during the menopause

(05:16) Why menopause feels like accelerated aging

(13:34) The role of fibre in managing changing hormones

(20:45) Understanding the estrobolome

(26:44) Are we missing a whole treatment avenue for perimenopause?

(31:04) Common gut signs when going through perimenopause

(33:31) The gut-brain axis and its impact on anxiety and brain fog

(36:42) Does menopause gut advice differ from normal gut advice?

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🤖 Dr Karan's Digital Twin

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

Microplastics are everywhere - in the food we eat, the air we breathe, and the environment around us. But how much do we actually know about what they are doing inside the human body?

In this episode I speak to microplastics researcher Dr Stephanie Wright to discuss everything from the difference between micro and nanoplastics, how particles interact with cells and the immune system and how researchers even measure plastic in blood and tissues.

Timestamps

(0:00) Intro - Are microplastics actually harming us?

(0:51) What do we actually know about the health effects?

(2:00) What animal studies can - and can't - tell us

(4:16) Should we be more concerned about nanoplastics?

(5:52) How could microplastics cause harm inside the body?

(7:50) Microplastics, the gut and the immune system

(9:03) How do we measure microplastics in the body?

(12:06) Microplastics in the brain - what was wrong with the research?

(14:19) How much microplastic are we actually exposed to?

(15:40) Can microplastics be removed from the body?

(17:01) The biggest sources: heating plastic, tea bags and tyre wear

(19:16) Which foods contain the most microplastics?

(20:37) Can plants absorb nanoplastics from soil?

(21:45) Microplastics in the placenta and fetus

(24:00) Will microplastics accumulate as we age?

(25:50) Are we blaming microplastics for too many health problems?

(27:00) The 'exposome' - why your whole environment matters

(30:58) How dangerous are microplastics compared with other pollutants?

(32:14) Can fibre help remove microplastics?

(38:50) What we still don't know about microplastics

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🤖 Dr Karan's Digital Twin

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan

Why does your body fight so hard to keep you at the same weight - even if it’s an unhealthy weight?

In this episode I speak to Dr. Simon Cork,  an  expert in appetite and gut hormone physiology at Anglia Ruskin University. He explains why our hormones trick our body into weight gain and what GLP-1 medications actually do to your gut and brain.  

Timestamps

(0:00) Intro - Why it’s so tough to shift our weight from baseline

(3:14) If weight “set points” exist, why is everyone gaining weight?

(5:22) What leptin is really doing for your hunger

(8:31) The gut-brain axis and the role of the vagus nerve

(10:31) How long does it take to know you’re full from eating?

(14:01) Can you resensitise your leptin signals?

(17:11) Does vagus nerve stimulation work to reduce hunger?

(19:24) Can you maintain the effects of GLP-1s without taking them forever?

(23:23) Can GLP-1s be used effectively outside of weight loss?

(31:43) Why some people are non-responders to GLP-1s

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

When broadcaster Jamie East got diagnosed with leukemia, he documented his whole journey and made a podcast about it. During his search for answers he discovered a world of horrendous cancer misinformation - and it made him furious.

In this episode Jamie talks about his cancer journey in a frank and honest way - the subject of his new podcast ‘Bad Blood’.

Timestamps

(0:00) Intro - When Jamie found out he had leukemia

(2:05) The symptoms

(7:00) How it feels for doctors delivering bad news

(11:48) Why leukemia symptoms go unnoticed

(14:04) Should you use Google to look up your diagnosis?

(18:01) The misinformation Jamie discovered

(23:02) The tricks grifters use to spread misinformation

(26:46) The sugar and cancer myth

(29:49) Why we need to stop blaming cancer patients

(32:08) The “fighting” language around cancer

(36:33) How some cancer drugs impact your life

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🤖 Dr Karan's Digital Twin

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

Most of us only pay attention to the fat around our bellies or our hips, but there’s a hidden fat we’re just ignoring. You can’t see visceral fat, but too much of it is dangerous - even slim people can have harmful levels without even knowing.

In this episode I speak to visceral fat expert Professor Jimmy Bell to find out what it’s doing in our bodies when there’s too much - and why you shouldn’t be worrying about weight if you want to stay healthy. 

Timestamps

(0:00) Intro - The role of fat in your body

(4:16) Why fat is actually a good thing

(8:18) Visceral fat vs subcutaneous fat 

(11:37) Thin on the outside - fat on the inside

(19:43) Why you shouldn’t chase scale weight

(22:28) Differences between where men and women store fat

(27:25) Do genetics affect baseline levels of visceral fat?

(32:25) How weight loss injections are impacting visceral fat

(37:03) The role of fast food in visceral fat accumulation

(42:31) Is the gut linked to fat gain?

(44:18) What should you do to reduce visceral fat?

 🦠LOAM Science 

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🤖 Dr Karan's Digital Twin

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http://DrKaran.ai 

About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

How worried should we really be about glyphosate? There’s growing fear that the world’s most popular weed killer is causing everything from cancer to gut problems. But is the evidence clear enough?

In this episode I speak to Professor Michael Antoniou, who explains what he’s discovered by studying the health effects of glyphosate exposure - particularly within commercial formulations. 

Timestamps

(0:00) Intro - The growing fear around glyphosate

(0:42) What is glyphosate and how does it work?

(5:53) The link between glyphosate and GMOs

(7:42) The microbiome impact

(11:48) Does the fear match reality?

(19:55) Why did regulators conclude it was safe?

(22:07) Why we should test commercial formulations

(25:34) Why microbiome work is still early stage

(28:30) Do some foods carry more glyphosate?

(30:00) Is glyphosate responsible for a reduction in soil quality?

(34:03) Why we still need more human data

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🚽 Throne Science

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Order my new book covering everything you're too embarrassed to ask your doctor but really should.

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🤖 Dr Karan's Digital Twin

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About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

Fatty liver disease affects a massive 1 in 3 people, yet most of us don’t even realise we have it - until it’s too late. But it is reversible. I know, because I’ve done it myself.

In this episode I speak to Dr Vishal Patel, Consultant Hepatologist & Endoscopist at the Liver Unit, King's College Hospital. He breaks down the surprising impact of liver health on your whole body, warning signs that something’s wrong - and how to protect your liver.

Timestamps

(0:00) Intro - Why you need to rethink liver health

(3:05) What impact does the liver have throughout the body?

(5:37) How Dr Karan discovered he had fatty liver disease

(11:09) How long do you have to address fatty liver disease?

(16:25) How weight loss makes the biggest difference

(19:21) How food can increase liver function

(22:46) Why fibre recommendations are still not enough

(25:17) Why some supplements can make liver health worse

(31:15) Are there signs your liver health isn’t good?

(36:06) How much can your liver actually process?

(39:34) How liver health links to oral health and the gut microbiome

 🦠LOAM Science 

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🚽 Throne Science

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Get $80 off with code DRKARAN: 

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📕 This Book May Save Your Life

The No.1 Sunday Times bestseller packed with evidence-based advice to improve your health.

https://geni.us/DrKaranBook 

📕 This Is Vital Information

Order my new book covering everything you're too embarrassed to ask your doctor but really should.

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🤖 Dr Karan's Digital Twin

Ask my AI twin your health questions anytime.

http://DrKaran.ai 

About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

Microplastics are everywhere - in the food we eat, the water we drink, and even the air we breathe. Increasingly, we hear about the dangers of these tiny particles - but what happens when they make their way into our bodies; and what could it mean for our health, and the environment?

In this episode I speak to microplastics researcher Dana Zhaxylykova, to discover what we should know about micro and nanoplastics, and their effects on the human body and world as a whole - where we’re exposed to them, how the food chain and environment is impacted, and how they may interact with our cells, organs and immune system. We explore what the science tells us so far, what remains uncertain, and whether there are practical steps we can take to reduce our exposure.

Timestamps

(0:00) Intro - What are microplastics?

(1:22) Why are we hearing so much about microplastics now?

(3:06) Environmental worries of plastic pollution

(7:40) Human health impacts

(8:57) The “credit card-sized” ingestion estimate 

(9:34) The main culprits of exposure to microplastics

(12:29) How harm from micro and nano plastics occurs

(15:59) Can microplastics be removed from the body?

(18:30) Research into health effects

(19:45) Impacts of microplastics on the gut

(21:28) How will microplastics shape the planet going forward?

(22:12) How tardigrades are immune and use microplastics to travel

(23:25) How could enzymes and probiotics help?

(26:25) Are particular areas of the world disproportionately affected?

(29:09) What regulations and controls are there?

(32:22) Top tips for people to reduce microplastic burden

🦠LOAM Science 

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🚽 Throne Science

Discover the world’s first continuous tracker for getting personalized insight about gut health, hydration, and prostate health with every flush.

Get $80 off with code DRKARAN: 

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📕 This Book May Save Your Life

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https://geni.us/DrKaranBook 

📕 This Is Vital Information

Order my new book covering everything you're too embarrassed to ask your doctor but really should.

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🤖 Dr Karan's Digital Twin

Ask my AI twin your health questions anytime.

http://DrKaran.ai 

About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan 

Muscle gain is an essential part of living longer and healthier - but there’s a lot of conflicting advice online. So how do you make resistance training and protein intake easy?

In this episode I speak to Leigh Breen, Professor of Translational Physiology, who breaks down the simple science of optimising muscle health - and explains how muscle affects the health of your whole body. 

Timestamps

(0:00) Intro - What muscle really does for your health

(2:32) What actually happens to your body after you exercise?

(4:30) How muscle and exercise improves brain health

(8:37) The gut-muscle axis

(12:13) Why optimising for protein may be a mistake

(14:24) How much protein do we really need?

(17:25) Can too much protein cause gut problems?

(19:18) How effective is collagen protein?

(28:46) The role of protein in the GLP-1 economy

(31:48) Why plant protein is just as good as animal protein

(35:45) GLP-1 impacts on muscle loss

(42:20) Weight independent benefits of weight loss drugs

(45:22) How age affects muscle strength

(48:08) Can you build back muscle after long periods of inactivity?

 🦠LOAM Science 

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🚽 Throne Science

Discover the world’s first continuous tracker for getting personalized insight about gut health, hydration, and prostate health with every flush.

Get $80 off with code DRKARAN: 

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📧Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: 

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📕 This Book May Save Your Life

The No.1 Sunday Times bestseller packed with evidence-based advice to improve your health.

https://geni.us/DrKaranBook 

📕 This Is Vital Information

Order my new book covering everything you're too embarrassed to ask your doctor but really should.

https://linktr.ee/ThisisVitalInformation 

🤖 Dr Karan's Digital Twin

Ask my AI twin your health questions anytime.

http://DrKaran.ai 

About Dr Karan:

Dr. Karan Rajan is a doctor, author, Founder of LOAM Science and Chief of Science at Throne Science, dedicated to making health and medical science accessible to all. Through evidence-based analysis, he addresses topics such as gut health, brain health, and healthy lifestyle choices, while dispelling common medical myths with a touch of dark humor.

📱Connect with me:

Instagram: https://www.instagram.com/drkaranrajan/ 

TikTok: https://www.tiktok.com/@dr.karanr 

Facebook: https://www.facebook.com/DrKaranR/ 

Website: www.drkaranrajan.com 

X: https://twitter.com/drkaranrajan