💬 Jens Walter is a gut health expert at APC Microbiome Ireland, one of the leading microbiome centres in the world - and helped develop the Non-industrialised Microbiome Restore (NiMe) diet.

⚡️In this episode, Jens and I discuss how our microbiomes have been shaped throughout human history - and the foods we can eat to make our healthy microbes flourish. 

🎧 Stay tuned to find out:

➡︎ Just how different our guts are from indigenous communities and our early ancestors

➡︎ What the NiMe diet is and how it can supercharge your gut health

➡︎ Why community and culture is just as important as food for gut health

➡︎ Why some of our gut microbes have gone extinct

➡︎ How pairing meat with the right kind of fibre can increase its benefits

📕 Chapters

(00:43) How industrialisation has changed our microbiome

(02:18) Do personalised diets work for gut health?

(05:52) Emerging gut microbe research

(07:27) How sharing microbes in communities improves gut health

(12:56) Combining the benefits of Western and indigenous lifestyles

(15:01) How different our guts are from ancient humans

(18:15) Can we regain extinct microbes?

(21:35) Exploring the Yanomami tribe

(24:11) The NiMe diet

(27:14) Should we cut out all dairy?

(30:01) Balance vs restriction

(32:23) Benefits of pairing fibre with meat

(35:27) Best resistant starches to eat

(38:36) Ancient vegetables: Are they better for us?

📱 Connect with me:

Instagram: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

TikTok: https://www.tiktok.com/@dr.karanr

📱 Connect with Jens Walter:

LinkedIn: https://www.linkedin.com/in/jens-walter-b1a1127a/

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Dr Spencer Nadolsky is an obesity and lipid specialist, and an expert in GLP-1 care. He’s also the co-host of the Docs Who Lift podcast.

⚡️In this episode Spencer and I discuss emerging research around weight loss injections tirzepatide and semaglutide, known as Ozempic, Wegovy and Mounjaro - and discuss the proper use of these drugs.

🎧 Stay tuned to find out:

➡︎ Why old restrictions on weight loss drugs are no longer being enforced

➡ How a combo of GLP-1 and GIP may be even more revolutionary for weight loss

➡︎ Why most people have to take these drugs for life

➡︎ Why people get so angry when people lose weight on GLP-1s

➡︎  How GLP-1 drugs are going to make weight-loss surgery extinct

📕 Chapters

(0:41) The non-weight loss benefits from GLP-1 use

(4:55) Getting the dosage right

(7:24) Drugs of the future

(11:09) How to get started on a weight-loss injection

(16:38) Why restrictions on weight loss drugs are being lifted

(19:46) Why people get mad about GLP-1 use

(23:57) Do you have to take these drugs for life?

(27:55) Do fat cells have memory?

(29:25) What if you want to stop GLP-1 use?

(31:48) The mental health drawbacks of weight loss drugs

(35:44) Unique insights from Spencer’s time with patients

(38:47) Is excessive muscle loss really a big problem?

(42:46) Should everyone be taking GLP-1s?

(45:14) Will weight loss surgeries go extinct?

(49:11) GLP supplements are a scam

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Spencer:

Instagram: https://www.instagram.com/drnadolsky/ 

X: https://x.com/DrNadolsky  

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Ro Huntriss is a world-leading fertility expert, recently crowned ‘Best Fertility Dietitian’ by The European Fertility Society. She has extensive experience in women’s health and is also the author of Deliciously Healthy Fertility.

⚡️In this episode Ro and I discuss the incredible power we have to influence our own ability to conceive (for both women and men) and improve the health outcomes of our children - simply by focusing on the food we eat.

🎧 Stay tuned to find out:

➡ Fertility friendly foods - and what to avoid for better conception

➡︎ What DNA fragmentation has to do with male fertility and sperm quality

➡︎ About the rise of ‘Ozempic babies’ and how GLP-1 agonists impact fertility

➡︎  The evolving role of microbiome research in fertility

➡︎ Which supplements actually work

📕 Chapters

(0:41) Fertility award winner

(1:51) How men are involved in fertility

(4:44) Why is infertility so common?

(6:34) Fertility friendly foods

(8:18) Dietary reasons for low fertility

(10:09) Fertility and the microbiome

(18:14) Supplements for fertility

(24:14) Testing your fertility

(28:43) How your diet improves your child’s long-term health

(30:36) Advice for chronic conditions like endometriosis

(35:52) Ozempic babies

(40:29) Dr Karan’s Ozempic prediction

(42:38) What you should STOP doing for fertility

(45:24) Diet impact on pregnancy related complications

(47:00) Improving fertility can be simple

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Ro:

Instagram: https://www.instagram.com/fertility.dietitian.uk/

Website: https://dietitianro.co.uk/ 

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Dr  Megan Rossi, aka The Gut Health Doctor, is an award‑winning dietitian and nutritionist with a PhD in gut microbiome science. She's the founder of The Gut Health Clinic and the Bio&Me food brand. She’s also a Sunday Times bestselling author, dedicated to translating cutting-edge gut research into practical, real‑world health advice.

⚡️In this episode, Megan and I dive into the science of gut health, exploring how your gut influences everything from mood and immunity to skin and sleep… and what you can do to improve it.

🎧 Stay tuned to find out:

➡︎ How your gut health impacts your mood, energy, skin, and overall wellbeing

➡︎ Why you need to eat 30 different plant-based foods per week

➡︎ Which fermented foods can naturally boost gut health

➡︎ The gut effects of artificial sweeteners and ultra-processed foods

➡︎ How stress, sleep, and movement affect gut health

📕 Chapters

(00:50) What’s so special about gut health?

(02:38) Don’t assume you’ve got a healthy gut

(04:42) Quickfire questions

(06:17) The importance of gut health

(09:16) Good bugs versus bad bugs

(12:06) Diversity is good for the gut

(14:23) The Super Six

(17:15) Should you restrict dairy?

(19:39) Probiotic foods and lactose intolerance

(23:05) Causes of bloating

(28:32) Fermented food benefits

(31:44) What’s the difference between probiotic supplements and fermented foods?

(35:22) Why fermented foods aren’t the answer for specific conditions

(37:26) Understanding the power of probiotics

(38:56) Can you trust off-the-shelf probiotics?

📱 Connect with me:

Instagram: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

TikTok: https://www.tiktok.com/@dr.karanr

📱 Connect with Dr Megan Rossi:

Instagram: https://www.instagram.com/theguthealthdoctor

TikTok: https://www.tiktok.com/@theguthealthdoctor

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Alex Ruani is a doctoral researcher in diet-health misinformation at University College London. She studies how misinformation spreads, the potential harm it can do - and what techniques we should be using to stop it.

⚡️In this episode Alex and I discuss the rising influence of technology and artificial intelligence on fake news and the spreading of misinformation - including how I’ve recently become the victim of a deepfake scam.

🎧 Stay tuned to find out:

➡︎ Why social media platforms say misinformation is a “necessary weed”

➡ How misinformation online is leading to real life deaths

➡︎ How AI is getting so good at spreading misinformation - threatening democracy

➡︎ How one company used a Deepfake clone of ME to sell their supplements

➡︎  Why the CapCut issue opens up massive trust issues with tech companies

📕 Chapters

(0:58) How bad is misinformation right now?

(4:38) How easy it is to avoid spreading fake news

(7:19) Is misinformation research working?

(12:16) Why social media platforms don’t want to tackle misinformation

(17:14) How to avoid restricting free speech

(22:12) How I got Deepfaked

(32:24) The CapCut problem: Why you should read Ts&Cs

(40:47) We’re using ChatGPT wrong

(46:16) How AI is rotting your brain

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Alex:

Instagram: https://www.instagram.com/alexruani/ 

LinkedIn: https://www.linkedin.com/in/alejandraruani/ 

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Dr. Giles Yeo is a geneticist and obesity researcher at the University of Cambridge. He specialises in how brain and genetic factors influence appetite and body weight regulation. He’s known for communicating complex science around obesity, appetite, and nutrition in an accessible way through media, books, and public talks.

⚡️In this episode, Giles and I dig into how our genes - especially those in the brain’s appetite and reward centres - shape our hunger signals, fat storage, and body fat “set‑points”. We explain why diets often fail and how to reset our appetite.

🎧 Stay tuned to find out:

➡︎ Just how strongly our genes are to blame for appetite and body weight

➡︎ The specific brain region that regulates hunger and energy balance

➡︎ Whether weight loss injections are really the answer

➡︎ Why obesity is biological - not a moral failing

➡︎ The 3 numbers to remember for weight loss

📕 Chapters

(00:47) Welcome back

(01:01) The genetic reason for obesity

(02:49) The role of the brain in weight gain

(05:15) Reward, hunger and fullness

(08:14) How fat cells influence how hungry you are

(10:09) The hypothalamus map

(13:19) What to do when your meal’s not enough

(16:16) Why hormones don’t limit your appetite

(18:21) The paradox of leptin resistance

(20:55) Insulin resistance and weight gain

(22:30) Defining high quality weight loss

(24:56) The yo-yo effect

(26:13) Why weight loss drugs aren’t enough

(30:17) The wider benefits of GLP-1 agonist weight loss drugs

(34:19) Gene mutation and obesity

(37:43) Gut hormones and the role they play

(41:06) The effect of early years education

(44:30) Three numbers to remember

(46:23) Your DNA isn’t your destiny

📱 Connect with me:

Instagram: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

TikTok: https://www.tiktok.com/@dr.karanr

📱 Connect with Dr Giles Yeo:

Instagram: https://www.instagram.com/gilesyeo

X: https://x.com/GilesYeo 

📕 Grab Giles’ book here: https://amzn.eu/d/hoAnVLr 

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Rhiannon Lambert is a nutritionist and author of newly released book “The Unprocessed Plate: Simple, Flavourful UPF-free Recipes to Transform Your Life”.

⚡️In this episode Rhiannon and I unpack some of the more worrying stats around ultra-processed food, discuss practical advice on how you can stop over-eating and improve your nutrition easily - and add some much needed nuance to the subject.

🎧 Stay tuned to find out:

➡︎ Simple ways to swap out junk food for healthier, tastier options

➡︎ Why back of pack calorie information can be wrong by up to 30%

➡︎  How food marketing and UPFs are damaging children the most

➡︎ The income issue of healthy eating - how 2.3 million people don’t have fridges 

➡ Why a lack of food culture leads to worse health outcomes

📕 Chapters

(0:46) Understanding the stats: How UPF increases mortality risk

(3:17) What is ultra-processed food?

(5:08) 60% of our diets are ultra-processed: does it matter?

(8:40) Why 2.8m people don’t have fridges

(10:03) The psychology of over-eating

(17:51) How food marketing is damaging children

(21:20) How wrong are back of pack calorie labels?

(23:46) Getting protein from UPF sources

(27:29) Nutrients most affected by processing

(32:30) The need for food culture

(36:28) Where most people fall down with UPF over-eating

(38:17) Simple whole food swaps to improve your diet

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Rhiannon:

Instagram: https://www.instagram.com/rhitrition/ 

Website: https://www.rhitrition.com/ 📕 Buy Rhiannon's new book The Unprocessed Plate here: https://www.amazon.co.uk/Unprocessed-Plate-Flavourful-UPF-free-Transform/dp/0241752655

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Gabrielle Palmeri is a nutritionist, gut health dietician and self-professed fibre freak. She’s seen first hand the rising rates of colon cancer, especially in younger people, linked directly to poor fibre intake. 

⚡️In this episode Gabrielle and I explore our mutual love of fibre and its amazing health benefits, and explain how you can easily up your intake.

🎧 Stay tuned to find out:

➡︎ The incredible number of health benefits you get from upping your fibre

➡︎ Why fibre diversity is just as important as upping the amount you’re eating

➡︎  How new research shows we seriously need to rethink fibre guidelines 

➡︎ Easy recipe tips to make delicious, fibre-rich snacks and meals

➡ Whether gut health snacks and fibre sodas are worth your money

📕 Chapters

(0:43) Why fibre is so significant

(1:36) How much fibre are we actually eating?

(3:59) How to eat more fibre without feeling overwhelmed

(6:18) Build your fibre intake up slowly

(8:40) Solution vs insoluble fibre

(11:53) Do fibre enriched gut health sodas work?

(14:27) How fibre helps weight loss

(18:11) Why colon cancer is on the rise

(22:53) What’s better, high fibre or diversity?

(24:17) Why fibre guidelines need to be updated

(29:04) Signs your body is low on fibre

(31:19) Quickfire questions

(34:32) Easy fibre meals

(36:21) Biggest fibre myth

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Gabrielle:Instagram: https://www.instagram.com/dietitian.gabrielle/?hl=en

Website: https://stan.store/dietitiangabrielle

YouTube: https://www.youtube.com/@dietitian.gabrielle

TikTok: https://www.tiktok.com/@dietitian.gabrielle?lang=en

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Cory Ruth is a registered dietitian and women’s health expert. As someone who suffers from PCOS, she has an intimate knowledge on the subject - and has dedicated her life to learning about the condition.

⚡️In this episode Cory and I dig into the science of PCOS and the dietary and lifestyle strategies that can help women take control of their health, weight and vitality - and heal their bodies.

🎧 Stay tuned to find out:

➡︎ The common signs and symptoms of PCOS - and what doctors often miss

➡︎ Why PCOS isn’t just a gynecological condition - it’s a whole-body condition

➡︎  The link between gut health, insulin resistance and hormones

➡︎ The food you should eat more of - and what you should avoid

➡ The supplements that are actually worth your money for treating PCOS

📕 Chapters

(0:40) The science of PCOS & Cory’s health journey

(5:00) The insulin resistance connection

(7:28) Why PCOS is so easily dismissed by health pros

(10:57) Not just a gynecological condition

(14:05) Diet & how to eat with PCOS

(18:43) The problem of ultra-processed food

(21:13) How stress impacts PCOS

(24:17) The role of supplements

(27:33) Lab tests you should run

(30:36) Can Ozempic help?

(33:41) How to advocate for yourself as a patient

(37:34) Advice for the person newly diagnosed with PCOS

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Cory:

Instagram: https://www.instagram.com/thewomensdietitian/ 

Website: https://www.thewomensdietitian.com/about 

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.

💬 Blair Imani Ali is an author, historian and the creator of Smarter In Seconds, an online series that is helping change people’s perspectives on issues of politics, identity, race, health and more.

⚡️In this episode Blair and I delve into common biases that impact society, how we’re conditioned to think and feel the way we do, and how to find nuance in a polarised world of social media.

🎧 Stay tuned to find out:

➡︎  The difference between race, ethnicity, and nationality

➡︎ How racism affects the healthcare people receive

➡︎ What featurism is and why we make snap judgements about people

➡ Why feminism has developed a negative image - and what it’s really about

➡︎ How social media is hijacking our brains - and what to do about it

📕 Chapters

(1:00) The difference between race, ethnicity, and nationality

(8:20) Health impacts of racial biases and stereotypes

(19:25) Featurism - why we make snap judgements

(24:52) What feminism is really about

(32:51) Blair’s ADHD journey

(40:07) Living a non-traditional life

(44:57) How social media hijacks our brains

📱 Connect with me:

TikTok: https://www.instagram.com/drkaranrajan

YouTube: https://www.youtube.com/@DrKaran 

Instagram: https://www.tiktok.com/@dr.karanr

📱 Connect with Blair:

Instagram: https://www.instagram.com/blairimani/ 

YouTube: https://www.youtube.com/blairimani 

🔥 Get my free weekly newsletter filled with easy to action health tips, interesting facts and science to fill your curiosity: https://drkaran.beehiiv.com/subscribe

🔥 For more useful science for your everyday life, grab my best selling book “This Book May Save Your Life”: https://geni.us/DrKaranBook 

🎙️ An OG Podcasts production.