Longer life is changing what people over 50 expect from medicine, themselves, and the decades ahead. In this encore episode, Dr. Michael Roizen argues that aging is increasingly shaped by informed choices, while the current culture surrounding longevity struggles to separate useful evidence from expensive fads.

Roizen examines the science behind epigenetic switches, protein cycling, metformin, stem cells, cardiovascular risk, and balance. The conversation offers a practical framework for evaluating new claims, protecting physical and cognitive function, and asking better questions before adopting a new treatment or supplement.

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Key Moments

“You’re a better genetic engineer for you than anyone else who went to Caltech or MIT.”

"Stressing the muscle not only repairs the muscle, but it turns on a gene that produces a small protein, which gets to the brain and makes the brain bigger. That’s why physical activity, we think, is so good for memory."

"Can we make a hundred year old person a 40 year old person? In other words, can we extend the period of life between when you’re most productive, your 40s to 60s, to being between 40 and 90? And that’s where a lot of the aging mechanism research is going."

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Click Here for the full interview transcript.

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