How do you treat alcohol use disorder (formerly called alcoholism) without requiring total abstinence? This week, Dr. Paul Kolodzik returns to The AGEIST Podcast to discuss his pioneering work around GLP-1s: using these medications to help people reduce their alcohol intake. Drawing on his background in emergency and addiction medicine, Dr. Kolodzik outlines how these off-label uses can drastically reduce consumption, often by 60–70%, even in heavy drinkers. Learn why harm reduction, not abstinence, is a realistic and medically valid path for many and how medication paired with behavior change is reshaping addiction treatment today.

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Key Moments
“The better way to go for many people is to be completely abstinent. But I don’t think it’s the only way to go.”

“Almost universally, people that are put on GLP-1s decrease their drinking.”

“Alcohol withdrawal kills people... opiate withdrawal feels terrible, but it doesn’t kill people.”

Connect with Dr. Kolodzik
Website (The Metabolic MD)

North Dayton Addiction & Recovery Services

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Click Here for the full interview transcript.

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