Podcast Notes Key Takeaways

• With a blood test, Peter looks for the following in regards to longevity:
  • What is this person’s risk of atherosclerotic disease or stroke? (this is largely driven by – lipoprotiens, inflammation, and endothelial dysfunction)
    • With a blood test, in the lipoprotein department, you can measure – Lp(a), LDL, LDL particle number, cholesterol, and vLDL
      • Note – The higher your Lp(a) – the greater your chance of cardiovascular mortality
    • On the inflammation side, you can measure specific and non-specific markers of inflammation (specific in regards to where the inflammation is coming from)
      • Non-specific – Fibrinogen, C-reactive protein (CRP)
      • Specific – Oxidized LDL (Ox-LDL), Lp-PLA2, Oxidized Phospholipid (Ox-PL)
    • For endothelial health, a blood test allows one to measure – insulin, homocysteine, ADMA and SDMA (both inhibitors of nitric oxide synthase)
    • In general – the younger you are, the more a blood tells you about your risk of cardiovascular diseaser 
  • What is this person’s risk of cancer?
    • “This is where blood gives us the least insight”
    • Cancer really comes down to understanding inflammation and metabolic health
      • One key factor here – minimizing hyperinsulinemia 
  • What is this person’s risk of neurodegenerative disease?
    • Alzheimer’s Disease is closely related to cardiovascular disease in terms of risk stratification 
      • Your ApoE genotype (measured with a DNA analysis) immediately qualifies you as low, medium, or high risk
• What about fasting blood glucose?
  • If you’re fasting blood glucose level is 150 mg/dL – there’s clearly a problem
  • “Now that I wear a continuous glucose monitor and I know my glucose 24/7, the difference between a fasting glucose of 90 and 105 in the morning is much more a function of my cortisol level than it is anything to do with insulin sensitivity”
    • In simple terms – stress and a lack of sleep can raise your fasting blood glucose

Read the full notes @ podcastnotes.org



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