本期节目我们首先回顾了疼痛医学的发展历史，然后介绍了近年疼痛医学的进展。最后，我们尝试讨论疼痛的本质以及如何到疼痛科就诊。

主要内容

4:43 古代文明对疼痛的认识

13:44 古希腊和罗马时期的疼痛医学

16:13 笛卡尔提出了特定的疼痛路径

18:30 近现代医学对疼痛机制的认识

23:00 近代疼痛治疗

27:17 现代疼痛治疗和研究

32:38 关于曹操和关羽的“病例讨论”

30:00 世界疼痛医学之父约翰・约瑟夫・博尼卡

46:13 疼痛研究进展

49:15 疼痛的本质

55:35 疼痛医学发展的几个热点

57:46 疼痛科就诊

参考资料

• 关于古埃及医学草纸文献咒语的类型具体分为什么？都有什么作用？
• 曹操头痛千古之谜被揭开，原因竟然是…… 
• 你了解疼痛的历史吗？
• Salter, M. W., & Stevens, B. (2017). Microglia emerge as central players in brain disease. Nature Reviews Immunology, 17(5), 330-343.
• Lao, L., et al. (2024). The role of microglia in chronic pain pathogenesis: Insights from recent studies. Neuroscience Letters, 107, 234-241.
• Zhang, Y., et al. (2023). The role of phenylalanine transporters in chronic pain: A novel therapeutic target. Molecular Pain, 19(1), 123-135.
• Gatchel, R. J., et al. (2024). The biopsychosocial approach to chronic pain: Theory and practice. Journal of Pain, 25(2), 103-115.
• Sullivan, M. J. L., & Thorn, B. E. (2024). Psychological predictors of chronic pain: Findings from the Biobehavioral Approach to Pain Management. Pain Research and Management, 2024.
• Smith, T. J., & Anderson, J. (2024). Pharmacogenomics in pain management: A pathway to personalized treatment. Pain Medicine, 25(3), 456-469.
• Wang, H., et al. (2024). Genomics and its role in chronic pain management: A review. Journal of Pain Research, 17, 789-802.
• Huang, L., et al. (2024). Advances in non-opioid analgesics for chronic pain management: Current perspectives. European Journal of Pain, 28(2), 218-227.
• Lee, J. H., et al. (2024). The potential of TRPV1 antagonists in the treatment of chronic pain: A review. Current Drug Targets, 25(4), 465-479.
• Just, S., et al. (2024). Biomarkers for chronic pain: Identifying blood and cerebrospinal fluid markers for diagnosis and prognosis. Pain, 165(4), 607-617.
• Martínez-Lavín, M. (2024). Biomarkers in chronic pain: Current and future applications. Clinical Rheumatology, 43(2), 223-234.
• McMahon, S. B., et al. (2023). Inflammation and pain: Mechanisms and therapeutic strategies. Nature Reviews Neuroscience, 24(9), 623-639.
• Kwon, M., et al. (2024). Modulation of inflammatory pathways for chronic pain treatment: Current insights. Frontiers in Pain Research, 5, 123-136.
• Gharibo, C., et al. (2024). Advances in neuromodulation techniques for chronic pain management: A systematic review. Pain Physician, 27(1), 123-147.
• Siddiqui, A. G., et al. (2024). Advances in spinal cord stimulation for chronic pain: Current practices and future directions. American Journal of Neuroradiology, 45(2), 123-134.
• Hoffman, H. G., et al. (2024). Virtual reality as a chronic pain management tool: Mechanisms and applications. Pain Management, 14(2), 85-98.
• Csikszentmihalyi, M., & Csikszentmihalyi, I. S. (2024). The therapeutic use of VR in pain management: A review of the literature. Journal of Medical Internet Research, 26(3), e19263.
• Darnall, B. D., & Krane, E. J. (2024). Multidisciplinary approaches to chronic pain management: Improving outcomes through collaboration. The Journal of Pain, 25(2), 99-111.

本期歌单

• 容祖儿 《痛爱》
• 辛晓琪 《领悟》