Root Cause Radio

Ep 188- MCAS Treatment Explained: Root Causes, Histamine Intolerance, and How to Calm the Storm


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Are you struggling with unexplained allergic reactions, chronic inflammation, rashes, fatigue, anxiety, or gut issues? You may be dealing with Mast Cell Activation Syndrome (MCAS)—a complex and often misunderstood immune system condition.

In this episode of Root Cause Radio, functional medicine dietitian and hormone specialist Lacey Dunn and Anya Rosen dive deep into:

  • What is MCAS and how it differs from histamine intolerance

  • Common MCAS symptoms like hives, flushing, brain fog, IBS, POTS, and more

  • Key root causes including mold toxicity, chronic infections (like Lyme or EBV), SIBO, stress, and trauma

  • How to identify triggers and reduce mast cell degranulation

  • The best natural supplements and low-histamine diet tips to stabilize mast cells

  • How to start to address gut health, detox , and nervous system dysregulation


Here is a time-stamped outline of the key points discussed in the meeting, organized by minutes:

0-1 minute: Introduction to the topic of mast cell activation syndrome (MCAS)

1-2 minutes: Anya discusses the increasing prevalence of MCAS diagnoses and the differences between histamine intolerance and MCAS

2-3 minutes: Lacey defines what mast cells are and how MCAS develops, as well as the differences between histamine intolerance and MCAS

3-5 minutes: Lacey outlines the wide range of MCAS symptoms across different body systems

5-7 minutes: Anya discusses the diagnostic criteria for MCAS

7-8 minutes: Lacey and Anya discuss mold as a common root cause for MCAS

8-9 minutes: Lacey identifies other potential root causes like infections, GI issues, genetics, and trauma/stress

9-10 minutes: Anya emphasizes the importance of stabilizing the nervous system before addressing root causes

10-12 minutes: Lacey and Anya recommend various natural supplements and medications for MCAS management

12-13 minutes: Lacey cautions about potential side effects of certain supplements like quercetin

13-15 minutes: Anya and Lacey discuss the role of lifestyle factors like reducing toxic exposures

15-17 minutes: Lacey notes connections between MCAS, POTS, and Ehlers-Danlos Syndrome, and advises against what can hold you back from healing

17-18 minutes: Lacey and Anya wrap up and encourage listeners to reach out for support

  • Identifying root causes beyond just mold @ 15:07
  • Emphasizing stabilizing the nervous system first @ 16:40
  • Discussing connections to other conditions like POTS and EDS @ 30:09


Need one on one help?

Lacey's info:

My Website & Work with Me: 

Instagram: ⁠www.instagram.com/faithandfit⁠

⁠www.upliftfitnutrition.com⁠

Email for coaching & phone consults: [email protected] & [email protected]

My Supplement Company:


Order my book "The Women's Guide to Hormonal Harmony" on amazon! 

Anya Rosen’s info:

Website: 

Instagram: 

Email: [email protected]

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