Episode 269 Part 1 hosts Dr Kate Goldie (Cosmetic Physician based in London, UK)

Kate is a globally-renowned speaker and KOL for Merz Aesthetics. She has lectured in over 75 countries and is a thought leader in aesthetics. She has a particular interest in regenerative medicine and is leading research into how to best use Radiesse (by Merz Aesthetics).

In our 'Masterclass Series' we host global experts with significant experience to teach us about fillers, bio-stimulators, bio-remodellers, polynucleotides, exosomes and other products. (For toxin insights, check out our other mini-series, 'The Tox Talks')

In Chapter 2 Part 1 (free and available on any podcast app) we discuss:

• What regenerative aesthetics means to injectors
• How and why our skin ages
• The role of fibroblasts
• How structure defines function in skin aging
• The role of collagen and elastin
• Pre-juvenation
• An introduction to calcium hydroxyapatite

00:00 Introduction 02:24 Two Part Episodes Patreon 03:04 Meet Dr Kate Goldie 05:07 Regenerative Aesthetics Mission 07:38 Masterclass Focus CaHA Radiesse 09:00 Behind the Scenes Exosome Research 15:17 Future of Regenerative Medicine AI 19:07 Sponsor Break Vida Soul 20:49 Reality Check Biostimulators 21:53 Three Pillars of Regenerative Aesthetics 23:37 Back to Basics Skin Aging 26:19 Why Skin Ages 27:42 Bowl of Soup Model 30:11 Homeostasis Breakdown 31:40 Lifestyle Stress Effects 34:22 Sponsor Offer Break 35:17 Fibroblasts and Mechanotransduction 37:30 Collagen Balance Windows 40:18 When Collagen Declines 44:01 Radiesse Explained 50:11 Off Label Innovation 52:28 Wrap Up and Subscribe

In Chaper 2 Part 2 (Now available inside our new app, IA Community, ahead of our official launch this May. Click here to join our waitlist), we discuss:

• Calcium hydroxyapatite as a material
• What Radiesse is
• How Sculptra differs to Radiesse
• The concept of hyperdiluted Radiesse and how to do it
• The difference between different hyperdilution ratios
• Protocols to treat the face, the neck and body
• Combination treatments with Radiesse and other injectables

00:00 Introduction 00:30 Radiesse Basics and Goals 01:06 Bone Lining Microdroplets 03:23 Dilution Effects and Planes 07:20 How to Mix Radiesse 09:05 Butterfly Technique and Four Ds 13:06 Comparing Radiesse vs Sculptra 15:42 Choosing the Right Tool 19:44 Treatment Rhythm and Scheduling 21:17 Younger Patients and Prevention 23:01 Consults and Setting Expectations 25:23 Youthful Skin Not Weird 26:03 Younger Versus Beautiful 27:56 Art Science Tissue Remodeling 30:05 Neck Treatment Deep Dive 32:11 Neck Dosing Zones Technique 35:20 Avoid Over Dilution Lumps 38:43 Who Needs Surgery Instead 39:29 Profilo Versus Radiesse 40:48 Body Areas Dilution Strategy 42:50 Nodules Safety Management 46:00 Future Regenerative Aesthetics 48:25 Wrap Up Resources Plug

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