In this episode of Iron Culture, Helms and Trex have a lengthy discussion about the ECA stack and yohimbine. The history, the mechanisms, the regulatory changes, the practical applications – you name it, they cover it. Don't miss this episode if you have an interest in fat loss, stimulants, or dietary supplementation in general.

Also, be sure to check out the newest issue of the MASS Research Review! Learn more at massresearchreview.com

Time stamps 0:00 Intro 4:18 New issue of the MASS Research Review 10:42 Helms contest prep update 13:15 The history of the ECA stack and supplement regulation 30:07 Ephedra vs Ephedrine 35:31 Why people took ephedrine / ECA stack 36:30 Trends in PED use over time 45:00 Research on the ECA stack 50:58 Banning lifters for stimulant use 53:15 Effects of ephedrine + caffeine on metabolism and fat loss 1:02:44 What does aspirin really add to the ECA stack? 1:13:00 Do NSAIDs blunt hypertrophy? 1:21:25 How yohimbine works (and yohimbe vs yohimbine distinction) 1:31:10 Regulatory status of yohimbine 1:32:58 Practical applications