Love Your Gut

Ep. 82: Histamine Intolerance, MCAS, and Your Gut: What’s Really Going On with Michelle Shapiro


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If you’ve been dealing with reflux, bloating, constipation, or even anxiety and can’t figure out why, histamines might be part of the picture. In this episode, I’m joined by Michelle Shapiro, RD, to break down the connection between histamine intolerance, MCAS, and gut symptoms and why so many people feel worse with standard gut protocols.

Michelle and I discuss: 

  • What histamine intolerance really is and how it overlaps with MCAS
  • The wide range of symptoms histamine issues can cause (and why they’re often missed)
  • How the gut, DAO enzyme, and microbiome influence histamine balance
  • Why nervous system support is just as important as gut support
  • Practical steps you can take if you suspect histamine intolerance

Michelle also shares her personal journey with histamines, mold exposure, and POTS and how slowing down and supporting safety in the body can be a turning point for healing.

Links Mentioned in the Episode:

  • Gupta Program (free 28 day trial with this link)

  • Michelle’s Histamine Essentials Webinar

  • Michelle's Sept 28th Webinar 

  • Michelle’s Website

  • Michelle’s Instagram

Stay Connected with Dr. Heather:

  • Follow on Instagram

  • Visit the Website

About Michelle: Michelle Shapiro, RD is a functional/ integrative Registered Dietitian who has helped over 3,000 clients transform their health over the past 11 years. As the founder of an NYC-based virtual private practice, Michelle leads a team of six expert nutritionists who specialize in complex cases including histamine issues, gut dysfunction, chronic anxiety, and weight concerns. She is the creator of the viral Histamine Essentials Webinar, which is available now on replay, and the host of the top-rated podcast Quiet the Diet, where she breaks down the science behind chronic illness in a way that actually makes sense and makes you feel seen. Michelle is the go-to expert for people who have tried everything and are ready for a real plan.

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Love Your GutBy Dr. Heather Finley

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