September 23, 2025

Episode 434: How Women’s Brains Change On Their Periods

40 minutes

It is well-known that PMS symptoms can deeply affect how women are feeling, including their mood, pain, and energy levels. But why exactly does this happen? Today, we’re going to dive into the science of sex hormones and the menstrual cycle, including how hormone levels affect women’s sexual motivation and tips for navigating sex at different phases of the cycle.

I am joined by Dr. Sarah Hill, the author of This is Your Brain on Birth Control. She has spent most of her 20+ year career studying women, relationships, and health. Her latest book is titled The Period Brain: The New Science of Why We PMS and How To Fix It.

Some of the specific topics we explore include:

What’s the deal with PMS? Why did women evolve to feel like crap for half of the menstrual cycle?

How do the rise and fall of different hormones during the cycle affect women’s brains?

Progesterone is a hormone that’s supposed to make us feel good. So why doesn’t it have that effect during the second half of the menstrual cycle?

How do estrogen and progesterone affect sexual motivation and desire?

You can check our Sarah’s website to learn more about her work.

Got a sex question? Send me a podcast voicemail to have it answered on a future episode at speakpipe.com/sexandpsychology.

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The Kinsey Institute at Indiana University has been a trusted source for scientific knowledge and research on critical issues in sexuality, gender, and reproduction for over 75 years. Be sure to register for the Sex and Aging Symposium, which will take place on October 4, 2025.

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Credits: Precision Podcasting (Podcast editing) and Shutterstock/Florian (Music). Image created with Canva; photos used with permission of guest.

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