In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood.

I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being.

Read the episode show notes at hubermanlab.com.

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Timestamps

00:00:00 Major Depression

00:01:10 Depression Symptoms

00:06:14 Sponsor: BetterHelp

00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin

00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics

00:17:43 Sponsor: AG1

00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise

00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise

00:26:49 Sponsor: Our Place

00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression

00:30:20 Novel Depression Therapies, Ketamine, Psilocybin

00:35:29 Ketogenic Diet & Refractory Depression, GABA

00:37:57 Recap & Key Takeaways

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