http://goo.gl/0B6h14

Read the full paper (for free): http://gut.bmj.com/content/63/7/1069.full

Mairi McLean talks to Robin Spiller, NIHR Nottingham Digestive Diseases Biomedical Research Unit, and David Tooth, School of Biomedical Sciences, University of Nottingham, about their paper: Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit.

Read the full article: http://goo.gl/0OIP34

Mairi McLean talks to Andres Acosta and Barham K Abu Dayyeh, both Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, about their review on the management of obesity.

Read the full paper: http://goo.gl/V37xaq

Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC.

Along with colleagues, Simon Eaton and Paolo De Coppi, both from University College London Institute of Child Health, have tested the hypothesis that amniotic fluid stem (AFS) cells exerted a beneficial effect in a neonatal rat model of NEC.

Mairi McLean discusses their findings with them.

Read the full paper:

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism http://goo.gl/EFUuN0

Gut's education editor Mairi McLean discusses highlights from the guidelines on the diagnosis and management of Barrett's oesophagus with authors Rebecca Fitzgerald and Massimiliano di Pietro, both from the MRC Cancer Unit, University of Cambridge.

Read the full paper here: http://bit.ly/1kkPkVW

Mairi McLean talks to Markus Peck-Radosavljevic, Division of Gastroenterology & Hepatology, Medical University Vienna, about his study looking at carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol.

Read the full paper here: bit.ly/1991biw

Mairi McLean talks to Anna Paterson and Rebecca Fitzgerald, both MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, about their study investigating whether a receptor tyrosine kinase (RTK) array could be used to select the most effective therapeutic strategies in molecularly heterogeneous oesophago-gastric adenocarcinomas.

Read the full paper here: bit.ly/1acACwz

Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease.

In this podcast Mairi McLean, Gut education editor, talks to Professor Yoshiro Niitsu from Sapporo Medical University School of Medicine about his manuscript about the potential for therapeutic use of siRNA in the treatment of pancreatic fibrosis.

Read the full research online:

http://gut.bmj.com/content/62/9/1328