Mairi McLean talks to Patrick Tan, associate professor, Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, and Heike Grabsch, Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, about their genomic meta-analysis to identify predictors of survival in patients with gastric cancer.

See also:

Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer http://goo.gl/Rw8lx6

Mairi McLean talks to Emeran Mayer, Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, UCLA, about his paper: An update on the use and investigation of probiotics in health and disease.

Read the full paper here: http://bit.ly/11ghKss

In this podcast, Mairi McLean interviews Julián Panés and Azucena Salas, both from the Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBER-EHD in Barcelona, Spain. They disuse their recent article, looking at transcription in the intestinal mucosa of patients with ulcerative colitis.

read the full article online: http://tinyurl.com/n3uy6d4

Mairi McLean talks to Philip Rosenstiel, Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, and Stefan Schreiber, University Hospital Schleswig-Holstein, Kiel, about their paper: mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn’s disease http://bit.ly/11FU0Qw.

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol http://bit.ly/10dtab8.

Before the UK national bowel cancer screening programmes were implemented, a pilot was set-up in England to see if results from randomised controlled trials could be replicated in the general population. Gut has recently published findings from the third round of this.

Co-author David Weller, Centre for Population Health Sciences–General Practice, University of Edinburgh, UK, talks to Gut’s associate editor William Grady about effectiveness of screening, uptake and its link to ethnicity, and the potential of different methods.

See also:

Performance measures in three rounds of the English bowel cancer screening pilot (http://tinyurl.com/afyj365)

Mairi McLean, Gut education editor, talks to Professor Mark Hull, Leeds Institute of Molecular Medicine, about his research into the action of polyunsaturated fatty acids on the formation of neoplams.

See also:

Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer (http://tinyurl.com/a7q8co4)

In the UK chronic gastrointestinal symptoms after cancer therapies have a similar impact as IBD. However, in contrast to patients with IBD, most of these patients won’t see a gastroenterologist. In this month’s Gut Editor’s Choice the causes of these side effects of cancer treatment are discussed, as well as the benefits of investigation and treatment.

In this podcast Mairi McLean, senior clinical lecturer and consultant in gastroenterology at the University of Aberdeen talks to some key stakeholders in this issue:

Professor Sir Mike Richards, national clinical director for cancer and end of life care, Department of Health

Jane Maher, chief medical officer for McMillian Cancer Support

Jon Rhodes, professor of gastroenterology and president of the British Society of Gastroenterology

Jervoise Andeyev, consultant gastroenterologist in pelvic radiation disease at the Royal Marsden NHS Trust, London

See also:

Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer (http://tinyurl.com/a6krvl8)

Liam O’Mahony (Swiss Institute of Allergy and Asthma Research) talks to Mairi McLean (senior clinical lecturer and consultant in gastroenterology at the University of Aberdeen) about his paper looking at Bifidobacterium infantis’s interaction with T cells, and the bacterium’s potential to protect against gastrointestinal inflammation.

See also:

Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells (http://tinyurl.com/b6xnnsx)

Mairi Mclean, Gut’s education editor, talks to Matteo Serino from the Institut National de la Santé et de la Recherche Médicale (INSERM), about his article Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota (http://tinyurl.com/a4rdl2e), which is this month’s editor’s choice.