What's the difference between bias and expertise? When a critic dismissed Amanda Knox's commentary on the Lucy Letby case as the grievance of a biased woman, the real question got buried: can lived experience be a form of expertise? And if so, what's the line between pattern recognition and confirmation bias? Amanda and Chris dig into the cognitive science, the structural failures of the justice system, and the countermeasures that might actually help us get it right.

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What is truth, and why does finding it actually matter? Amanda sits down with Dr. Michael Shermer, founding publisher of Skeptic Magazine, longtime Scientific American columnist, and author of Truth: What It Is, How to Find It, and Why It Still Matters, for a conversation that starts with epistemology and ends in a full-throated debate about free will.

They talk about why our brains evolved more like lawyers than scientists — to win arguments, not find facts. They get into the hard problem of consciousness, what meditation might reveal that neuroscience can't yet measure, and whether the legal system could ever be redesigned around actual truth-seeking. And then Amanda makes the case for hard determinism and nearly talks Shermer into it.

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After a stranger on Twitter told Amanda “Jesus, put on some makeup,” she responded with a joke: an AI image of Jesus wearing makeup and a one-word reply, “Fine.” The tweet went viral, drawing both laughter and accusations of blasphemy. In this episode, Amanda reflects on what that reaction reveals about fragile beliefs, the psychology of offense, and why learning not to be “capturable” by other people’s outrage is essential for living freely.

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John J. Lennon is a journalist, author of The Tragedy of True Crime, and a convicted murderer who joined Amanda for this conversation from prison, where he is currently incarcerated. In this challenging and deeply reflective episode, Amanda confronts Lennon about the limits of compassion, the ethics of true crime storytelling, and the danger of narratives that lock people into their worst moments.

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Amanda and Chris unpack the complicated idea of trauma bonds, from Amanda’s relationship with Raffaele during their wrongful imprisonment to the quieter survival mode of early parenthood. They explore how crisis can intensify connection, why Hollywood romanticizes trauma informed love, and what happens to relationships once the emergency ends. Along the way, they wrestle with whether trauma is objective or subjective, how identity shifts under pressure, and whether facing mortality together can create a bond that is destabilizing, transformative, or both.

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Tim Egan is a Pulitzer Prize–winning journalist, National Book Award–winning author, and longtime New York Times columnist who publicly challenged the media narrative around Amanda Knox’s case when few others would. In this episode, Amanda and Tim unpack how predatory journalism, cultural bias, and economic incentives fuel rushes to judgment, how misinformation erodes our ability to agree on basic facts, and why truth telling becomes harder and more necessary when narratives turn tribal. They also explore why history offers both warning signs and hope, and how ordinary individuals can still bend the arc toward justice.

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Lauren Weedman is an Emmy-nominated writer, comedian, and actor known her roles in HBO’s Looking, Hung and Hacks. She is also a renowned solo performer whose work is built on fearless honesty and dark humor. In this episode, Lauren gives Amanda a candid masterclass in solo storytelling, from why audiences hesitate to laugh at trauma, to how musical numbers, silence, and even a well timed cartwheel can unlock tension onstage. Along the way, they trade unforgettable moments about prison mugshots, shame, loneliness, and how a mother can balance the intense energy of a theatrical run with the demands of family life.

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Warren Littlefield is an award winning television producer and former NBC network president whose career spans landmark shows from Cheers to The Handmaid’s Tale and The Twisted Tale of Amanda Knox. In this candid and behind the scenes conversation, Warren and Amanda revisit the making of the series together, sharing stories about freezing fog in Vancouver, impossible production schedules, and the tiny details like suitcases and pastries that carry enormous emotional weight. Along the way, Warren reflects on firefighting in the entertainment industry, replacing Johnny Carson, embracing change, and why protecting creative vision, listening to your gut, and questioning official narratives matter far beyond television.

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In this Ask Amanda Anything episode, Amanda and Chris tackle big, tender questions about career pivots, privacy, creativity, and what it means to live openly without losing yourself. They share raw and funny stories about quitting “soul sucking” jobs, being the first person on the dance floor, and relearning joy after it was taken away. The conversation moves from Taoist ideas about following life’s current to the ethics of oversharing, offering a look at how curiosity, connection, and courage help us begin again.

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Maya Shankar is a cognitive scientist, writer, and host of the podcast A Slight Change of Plans, whose new book The Other Side of Change explores who we become when life takes an unexpected turn. In this rich and intimate conversation, Maya and Amanda dig into moments ranging from Juilliard dreams cut short by injury to miscarriage. They talk about locked-in syndrome, prison poetry, and the surprising psychology of why uncertainty can feel worse than pain. Along the way, Maya shares practical tools offering listeners a hopeful and deeply human guide to navigating change without platitudes.

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