In this episode of the Critical Oxygen podcast, Dr. Robert Jacobs and I discuss how our bodies adapt to exercise. We explore the various cellular disturbances that are sensed by specific sensors and translate into intracellular signaling cascades that drive adaptation. The key themes covered include the importance of stress and adaptation, the specificity of exercise adaptations, energetic and mechanical signals, redox balance, decreased partial pressure of oxygen, mechanical tension, and extracellular signals. This conversation explores the signaling effects of various molecules and stimuli on muscle adaptation and overall health.