Bryan Walsh, our favourite doctor, teacher and critical thinker is back on the podcast to talk about perhaps one of the most import of health topics: blood glucose regulation.

Why care about blood glucose? Didn’t I test that already?

Isn’t it time to move on and start thinking about something a bit sexier?

In this interview, Bryan argues no, and that the low hanging fruit remains whilst many practitioners move onto the harder to reach or less important interventions. I’m looking at you, MTHFR!

You could listen to this podcast to learn something about a class of hormone called incretins, the first-phase insulin response, and the primary action of insulin. If you like what you hear, I’d highly recommend you sign up for Bryan’s new training course, Everything You Ever Wanted To Know About Glucose Regulation.

Full disclosure: I am a true fan of Bryan’s. I buy everything he produces sight unseen. I’m always surprised and delighted by what I receive, and when listeners and clients ask me where I got my biochemistry and physiology education, I send them to Bryan. I pay full price for all Bryan’s work and there’s no financial affiliation.

[00:00:15] Podcast: Social Isolation: The Most Important Topic Nobody is Talking About with Dr Bryan Walsh.

[00:01:02] Cabbage Tree.

[00:02:36] Bridging the gap between conventional and naturopathic medicine.

[00:03:33] Sustained Health Engineering.

[00:04:43] Pellagra, Lyme Disease.

[00:05:32] Vitamin D.

[00:05:52] Article on Gizmodo: “Blowing Smoke Up Your Ass" Used to Be Literal.

[00:08:46] Blood glucose. Podcast: Poor Misunderstood Insulin with Dr Tommy Wood.  

[00:10:09] Infertility and libido.

[00:10:26] Depression and anxiety.

[00:10:50] HbA1c.

[00:11:56] Pathway ADD.

[00:12:40] Mapping the human genome.

[00:12:59] Microbiome.

[00:13:59] Low hanging fruit on a CBC paper.

[00:15:33] Blood glucose variability and long-term health.

[00:17:06] First phase insulin response.

[00:18:50] Second phase is insulin on demand.

[00:20:37] Blunted postprandial response is the earliest predictor of T2D.

[00:22:04] GlycoMark measures glycemic variability.

[00:24:26] GlycoMark < 15 indicates loss of the first phase insulin response.

[00:26:30] Glycated proteins, e.g. fructosamine.

[00:29:28] References for optimal ranges for fasting blood glucose.

[00:31:53] 80-90 mg/dL. Reference 1, 2, 3, and 4.

[00:33:36] Fasting blood glucose, how low should it go? References 1, 2, 3, and 4.

[00:34:23] Heart Rate Variability (HRV) and Podcast: Jason Moore of EliteHRV.

[00:34:40] PCOS and Podcast: Dr Frassetto of the PCOS Paleo Study.

[00:35:23] Incretins, GLP-1

[00:37:18] Gabor Erdosi at the Lower Insulin Facebook group.

[00:37:49] The primary action of insulin is to suppress glucagon.

[00:38:51] GABA.

[00:39:30] What is insulin resistance? Where does it happen?

[00:41:26] GLUT-4 transporters.

[00:42:11] Ceramides.

[00:42:33] Insulin resistance is protective.

[00:45:30] Insulin might be a bad idea. Study: Nolan, Christopher J., et al. "Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes." Diabetes 64.3 (2015): 673-686.

[00:48:13] What to do example.

[00:48:53] C-peptide.

[00:50:06] Chewing food and GLP-1. Study: Li, Jie, et al. "Improvement in chewing activity reduces energy intake in one meal and modulates plasma gut hormone concentrations in obese and lean young Chinese men." The American journal of clinical nutrition 94.3 (2011): 709-716.

[00:50:39] Quercetin, supplements.

[00:51:54] Course: Everything You Ever Wanted To Know About Glucose Dysregulation.

[00:55:19] Reactive hypoglycemia.

[00:57:06] 1,000 True Fans.

[00:58:09] For more from Dr Walsh check out: drwalsh.com, metabolicfitnesspro.com.

[00:59:10] Podcast: WAYYYY Beyond Diet & Exercise with Dr. Bryan Walsh.