The Autoimmune RESET

IBS, Leaky Gut & Autoimmune Arthritis: The LPS Connection You Need to Know


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IBS, Leaky Gut & Autoimmune Arthritis: The LPS Connection You Need to Know

In this episode, we’re exploring a hidden driver behind joint pain, chronic bloating, and immune dysfunction: the link between IBS, leaky gut, and autoimmune arthritis — and how a molecule called lipopolysaccharide (LPS) may be at the root of it all.

Join VJ Hamilton, registered nutritionist and autoimmune health specialist, as we unpack the science connecting gut permeability, systemic inflammation, and immune overactivation. You’ll discover why gut health is never just about digestion — and how the state of your microbiome can influence everything from your joints to your energy levels.

We also dive into:

  • What LPS is and how it triggers inflammatory pathways in autoimmune disease
  • Why people with rheumatoid arthritis and other autoimmune conditions often show signs of gut dysbiosis
  • The latest research on TLR4, LPS-binding protein, and the immune response in arthritis
  • How to tell if gut permeability could be contributing to your symptoms (even without a formal diagnosis)
  • Practical, evidence-based strategies to reduce LPS load and support gut-immune resilience

Plus, if you’re ready to reduce inflammation from the inside out, I share key tools and resources that can help you identify hidden triggers, nourish your gut lining, and take a systems-based approach to managing autoimmunity.

Resources Mentioned in the Episode
🧃 Join The Spring Juice RESET – A gentle 5-day protocol to support your liver, lymph, gut, and immune system (starting 8 April)
🔬 Read: At-Home Gut Health Testing Guide – How to test for gut imbalances and what markers to look for
🧠 Explore Nurosym – A non-invasive vagus nerve stimulation device to support stress resilience and inflammation reduction. Use code VH10 for 10% off at checkout. 

Perfect for you if:

  • You’re dealing with autoimmune arthritis, chronic gut issues, or unexplained inflammation
  • You’ve been told you have IBS, but suspect something deeper is going on
  • You’re looking for science-backed, root-cause approaches to immune and gut health

The information shared in this episode is for educational purposes only and is not intended to replace medical advice. Always consult with your healthcare provider before making changes to your medications, supplements, or protocols — especially if you have a diagnosed autoimmune condition.

Some resources or products mentioned in this episode may include affiliate links. This means I may earn a small commission if you choose to purchase through them — at no additional cost to you. I only recommend what I truly believe in and use in practice.

Thanks for listening! You can join The Autoimmune Forum on Facebook or find me on Instagram @theautoimmunitynutritionist.

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The Autoimmune RESETBy VJ Hamilton

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