Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Al Singer

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Links for this episode

• T cell FlipFlop mice reveal lineage determination (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Links for this episode

• KIR+CD8+ regulatory T cells (Science)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Links for this episode

• Age-dependent reduction in asthmatic pathology (J Immune)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

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Links for this episode

• Trogocytosis in Immune 18
• B cells steal from dendritic cells (Science)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Gabriel Victora

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Links for this episode

• Concerto in B (TWiV 161)
• Visualizing antibody affinity maturation (Science)
• Restricted B cell clonality after boosting (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Nikhil Joshi

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Links for this episode

• Creation of NINJA mice (Nature Biotech)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode

• DNA binding to TLR9 on red blood cells (Sci Transl Med)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Keke Fairfax

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Links for this episode

• Maternal schistosomiasis impairs offspring immunity (PloS Path)
• Helminth modulation of macrophage immunometabolism (Immune)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Timothy Hand

Click arrow to play Download Immune 48 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune!

Links for this episode

• Mouse model for EED (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode

• Antiviral IgA potentiates NETosis (PNAS)
• Letters read on Immune 47
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]