Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Mast cells and immune avoidance behavior (Nature)
• Immune sensing of food allergens promotes avoidance (Nature)
• Immunology that underlies picky eating (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Kevin joins Immune to discuss his work showing that antibodies against endogenous retroviruses promote immunotherapy of lung cancer.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Kevin Ng

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Antibodies against ERVs and lung cancer (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus.

Hosts: Vincent Racaniello, Cynthia Leifer, and Steph Langel

Download Immune 66 (45 MB .mp3, 76 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immunological imprinting (Immunity)
• COVID-19 vaccine imprinting (bioRxiv)
• Original antigenic sin (J Inf Dis)
• Are competition (LJII)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• T cells capable of supernumerary division (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• COVID-19 immune memory (Imm Rev)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Jonathan C. Kagan

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Approaching the asymptote (Cold Spring Harb Symp Quant Biol)
• Infection infidelities drive innate immunity (Science)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Tangled web of wires (Nature)
• Path to group A Streptococcus vaccines (Clin Inf Dis)
• Immune end-types predictive of vaccine responses (Nat Immunol)
• IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol)
• Very bad B cells (Immunity)
• Two epitope Streptococcus monoclonal (EMBO Mol Med)
• Predictor of vaccine-induced antibody responses (Nat Immunol)
• Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med)
• Neutrophilic inflammation and RSV infection (Science)
• Commensals avoiding recognition (Sci Immunol)
• Continuous germinal center invasion and immune response diversity (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• CAR T for SLE (Nat MEd)
• Maternal gut microbiome induced IgG (Sci Immunol)
• Long-primed germinal centers (Nature)
• Fc mediated protection against SARS-CoV-2 VOC (bioRxiv)
• Dark side of macrophages (Nat Med)
• Pregnancy and antibody protection against infection (Nature)
• Regulators of inflammatory response to mRNA vaccines (Nature Immunol)
• Antibody effector function and protection against RSV (Cell)
• Color coded antibodies (bioRxiv)
• Endogenous retroviruses and inflammation (Cell)
• CD8 T cells and vaccine protection against SARS-CoV-2 (Sci Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

De’Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests D’Broski Herbert

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• Immunology of helminth infections (Ann Rev Immunology)
• Neuroimmune regulatory networks (J Leuk Biol)
• Every cell is an immune cell (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

From SLB22 on the Island of Hawai’i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guests: Julia Bohannon and Musa Mhlanga

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• From the ashes (Richmond Register)
• Innate immune memory (J Immunol)
• Epigenetics and metabolism in trained immunity (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]