Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025

From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection.

Hosts: Cindy Leifer and Brianne Barker

Guest: Amanda Brown

• Society for Leukocyte Biology
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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• Non-neutralizing antibodies protect against CCHFV (Nat Comm)
• APC-T cell interactions drive immune responses to food (Science)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

 

 

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immune cells in cave nectar bats (Cell Rep)
• Cave nectar bat colony (J Am Asso Lab An Sci)
• Retrotransposons activate erythropoiesis (Science)
• TLRs and ERVs (Immunity)
• Letters read on Immune 88
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Basophils promote asthma (J Exp Med)
• Basophils regulate lung inflammation (J Exp Med)
• Neoself antigens are primary T cell targets in lupus (Cell)
• Time stamps by Jolene. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Nasal mucsosal macrophages, neuronal maintenance, and pathogen defense (Mucos Immunol)
• No long lived memory B cells after SARS-CoV-2 mRNA vaccination (Nat Comm)
• Time stamps by Jolene. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Immune memory diversity in human upper airway (Nature)
• How Plasmodium infection promotes B cell cancers (Cell)
• Time stamps by Jolene. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men).

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Guest: Petter Brodin

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Petter Brodin on TWiV 568
• Gender-affirming testosterone treatment (Nature)
• Time stamps by Jolene. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis.

Hosts: Cindy Leifer and Steph Langel

Guest: Mark Shlomchik

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease.

Hosts: Cindy Leifer and Brianne Barker

Guest: Heather Caslin

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

Links for this episode

• MicrobeTV Discord Server
• Microglia shape cortical development and behavior (Cell)
• Neutrophil trapping by mast cells (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]