Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Intranasal neomycin as antiviral (PNAS)
• Sexual dimorphism in skin immunity (Science)
• Maternal diet and infant respiratory health (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Depleting My-HSC rejuvenates aged immunity (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Adaptive immune responses preserved in hypervaccinated individual (Lancet)
• Synthetically glycosylated antigens for antigen-specific suppression of established immune responses (Nat Biomed Eng)
• Gut bacteria–derived serotonin promotes immune tolerance in early life (Sci Immunol)
• Immune correlates of viral control after SARS-CoV-2 challenge in adults (Sci Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Trans endothelial migration activates neutrophil killing (Immunity)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes.

Hosts: Vincent Racaniello, Steph Langel, Cynthia Leifer, and Brianne Barker

Guest: Juliet Morrison

Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Pleural macrophages move to the lung during influenza (PNAS)
• Time stamps by Jolene. Thanks!

Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Guest: Ang Cui

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Publishing is broken (Solving for Science)
• Immune Dictionary (Nature)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation.

Hosts: Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Carla R. Nowosad

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• B cells and the intestinal microbiome (Sem Immunol)
• B cell selection in gut germinal centres (Nature)
• B cell antigen internalization (Methods Mol Biol)
• Immune synapse architecture (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass.

Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Immune cells in the human body (PNAS)
• Letters read on Immune 73
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Ellen Rothenberg

Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Synthesis of infectious DNA of murine leukaemia virus (Nature)
• Runx factors launch T cell and innate lymphoid programs (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis, exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection.

Hosts: Cynthia Leifer, Stephanie Langel, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune!

• MicrobeTV Discord Server
• Helminth protects against murine SARS-CoV-2 infection (Sci Immunol)
• Pandemic spared Africa (ScienceInsider)
• Letters read on Immune 71
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]