Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

Guest: Alexander Dent

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• Loss of germinal centers in severe COVID-19 patients (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses.

Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker

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Links for this episode

• COVID-19 severity linked to antibody levels (bioRxiv)
• Review of antibody mediated immunity to coronaviruses (Nat Comm)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses.

Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker

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• Cross-reactive coronavirus CD4+ T cells (Science)
• Immune misfiring in severe COVID-19 (Nature)
• A COVID-19 riddle for the immune system (Nature)
• Letters read on Immune 34
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Links for this episode

• CD8 cells defend against SARS-CoV (J Virol)
• Deep immune profiling of COVID-19 patients (Science)
• Letters read on Immune 33
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker

Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune!

Links for this episode

• Keep CoV off campus (NY Times)
• Inflammatory cytokines predict COVID-19 death (medRxiv)
• Imbalanced host response drives COVID-19 (Cell)
• Convergent antibody responses in COVID-19 patients (bioRxiv)
• Cross neutralization of SARS-CoV-2 by SARS-CoV mAb (Nature)
• Human T-cell responses to SARS-CoV-2 (Cell)
• DNA vaccine protects rhesus macaques (Science)
• Replicon RNA vaccine protects macaques (bioRxiv)
• Letters read on Immune 32
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to [email protected]

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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• How long will a vaccine really take? (NYTimes)
• Humoral immunity in NYC COVID-19 patients (medRxiv)
• D614G is just a SNP (TWiEVO 55)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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• IL6 as COVID-19 marker for severity (Med Mal Infect)
• How does COVID-19 kill? (Nature)
• SARS-CoV-2 protective immunity in macaques (bioRxiv)
• SARS antibody titers wane (J Immunol)
• Vaccine roundup (Lab Equip)
• Lung IgG in SARS injury (JCI Insight)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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• ACE2 in oral mucosa (I J Oral Sci)
• IL6 predictor of COVID-19 death (Int Care Med)
• Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv)
• Antibody to SARS-CoV wanes (J Immunol)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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• Evolution of mucosal Ig in rainbow trout (Sci Immunol)
• Fish olfactory neurons mediate rapid immune response (PNAS)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• H3K4me1 mark on memory-like NK cells (Cell Rep)
• Letters read on Immune 27
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]