Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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• IL6 as COVID-19 marker for severity (Med Mal Infect)
• How does COVID-19 kill? (Nature)
• SARS-CoV-2 protective immunity in macaques (bioRxiv)
• SARS antibody titers wane (J Immunol)
• Vaccine roundup (Lab Equip)
• Lung IgG in SARS injury (JCI Insight)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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• ACE2 in oral mucosa (I J Oral Sci)
• IL6 predictor of COVID-19 death (Int Care Med)
• Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv)
• Antibody to SARS-CoV wanes (J Immunol)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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• Evolution of mucosal Ig in rainbow trout (Sci Immunol)
• Fish olfactory neurons mediate rapid immune response (PNAS)
• Image credit
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to [email protected]

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• H3K4me1 mark on memory-like NK cells (Cell Rep)
• Letters read on Immune 27
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

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Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

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• Measles virus infection diminishes pre-existing antibodies (Science)
• Public epitope #1 (TWiV 342)
• Incomplete reconstitution of B cell pools after measles (Sci Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical.

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The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• CD8+ T cell memory needs microbiome derived fatty acids (Immune)
• Image credit: Principles of Virology 4e
• Time stamps by Jolene. Thanks!
• Letters read on Immune 25

Stephanie - This Week in Neuroscience Cindy - Graduate Abuse by Derek Lowe Vincent - Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

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The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• New type of T helper cell drives anaphylaxis (Science)
• Image credit
• Time stamps by Jolene. Thanks!
• Letters read on Immune 24

Cindy- Lasker Award 2019 Vincent- Eleanor's Breakthrough video

Music by Steve Neal. Immune logo image by Blausen Medical.

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The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• Genetic variation in laboratory mice (Immunity)
• Time stamps by Jolene. Thanks!
• Vaccines and Your Child
• Letters read on Immune 23

Steph- University of Alaska budget crisis Cindy- 90% survival following new Ebolavirus treatments Vincent- Immunology videos at Blausen Medical

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• Engineering B cells to produce antiviral antibodies (Sci Immun)
• Time stamps by Jolene. Thanks!
• Letters read on Immune 22

Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prizes and Nature’s Surprises by Erling Norrby

Music by Steve Neal. Immune logo image by Blausen Medical.

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Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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• Dual receptor lymphocytes and type I diabetes (Cell)
• Image credit
• Time stamps by Jolene. Thanks!

Steph- Unique Scientists Cindy- Researcher app Vincent- STLR Conversations Podcast

Music by Steve Neal. Immune logo image by Blausen Medical.

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