Melvyn Bragg and guests discuss the history of mankind’s attempt to understand the nature of time. At the end of the 19th century, H.G.Wells imagined travelling through time in The Time Machine; “The palpitation of night and day merged into one continuous greyness; the sky took on a wonderful deepness of blue, a splendid luminous colour like that of early twilight; the jerking sun became a streak of fire, a brilliant arch in space”. When he was writing we thought time was unbending and universal and counted out by Newton’s clock. A hundred years later we have had Einstein and relativity, quantum theory, and atomic clocks, but in the third millennium, is mankind any closer to understanding what time really is? What, in short, do we know about time itself? A Greek philosopher thought that time was a figment of the imagination and there are contemporary physicists who go a long way to agreeing with him. Newton’s views on time were bent by Einstein. The ancient skills of astronomy once ruled the known world and skill in time usage could be said to be enthroned as a master craft in our day. “But at my back I always hear time’s winged chariot hurrying near and yonder all before us lie deserts of vast eternity” - Marvel wrote that of love, but it could be our epigraph for time. With Dr Neil Johnson, theoretical physicist at the Clarendon Laboratory, Oxford University and Royal Institution Christmas Lecturer 1999 on the subject of Time; Lee Smolin, cosmologist and Professor of Physics, Pennsylvania State University.

Melvyn Bragg examines the technological advances and ethics of modern medicine. On an average working day about three quarters of a million of us go to the doctor’s. About a hundred thousand are visited by nurses and other health professionals. Then there are the three hundred thousand that go to the dentist. Health is a central preoccupation. It is also big business, saving life, lengthening life and even promising a stab at eternal life. Yet while some technology is Space Age, the morality is often not far away from the Stone Age. Who decides who lives or dies? Insurance firms, for instance, want genetic information - should they have it? Stem cell research - hailed by many as an extraordinary advance - now runs into conflict with those who do not want the human embryo to be, as they see it, abused. In the 16th century Francis Bacon told us in his Advancement of Learning “Medicine is a science which hath been more professed than laboured, and yet more laboured than advanced: the labour having been, in my judgement, rather in a circle than in a progression”. Well, after a century that has brought us penicillin, the discovery of DNA, heart transplants and key-hole surgery, have we finally escaped the loop? Or does our ethical application of what we can technologically achieve mean we are marching in Bacon’s circle still? With Barry Jackson, consultant surgeon and President of the Royal College of Surgeons of England; Professor Sheila McLean, Director of the Institute of Law and Ethics in Medicine, Glasgow University.

Melvyn Bragg and guests discuss the problems of consciousness, one of the greatest mysteries facing science and philosophy today. The frustrations, the stubborn facts and the curiosities of today’s thinkers, philosophers, physicists and psychologists, demonstrate the elusiveness, and the utter impenetrability of consciousness. Can we explain our perception of colour, smell or what it is like to be in love in purely physical terms? Can memory, conviction and reason be explained primarily in terms of neural firing sequences in the brain? Three centuries ago Descartes famously believed that the problem was best solved by being ignored. Was he right? Could it be that the human mind is just not built to understand its own basis?With Ted Honderich, philosopher and former Grote Professor of the Philosophy of Mind and Logic, University College, London; Sir Roger Penrose eminent physicist, mathematician and author of The Large, The Small, and the Human Mind.

Melvyn Bragg and guests discuss the theory of Genetic Determinism. In the middle of the last century two men - Gregor Mendel, an Austrian monk, and Charles Darwin, an English naturalist, established the central theories of modern biology and changed the world forever. Darwin’s On the Origin of Species has been described as the book of the Millennium, “the only best-seller to change man’s conception of himself”. Through the rediscovery of Mendel’s work in the early decades of our century, evolutionary theory was transformed by the emergence of genetics as a science. Crick and Watson found DNA at Cambridge and announced that they had discovered the secret of life in a local pub, and the rest has been the most compulsive element in the intellectual history of the twentieth century. It seems as if almost every week we read about another gene which claims to determine our fate - whether it governs our intelligence, personality or sexual orientation. Many rail against what they see as “genetic determinism” - the idea that genes are the destiny we can do nothing about. Others willingly blame their anti-social behaviour on “criminal genes” - thus absolving themselves of any responsibility. Genetics may be all about inheritance but is inheritance all about the genes? With Steve Jones, Professor of Genetics, University College, London and author of Almost Like a Whale: The Origin of Species Updated; Matt Ridley, science journalist, chairman of the International Centre for Life and author of Genome: The autobiography of a species in 23 chapters.

Melvyn Bragg and guests discuss pain; something of which everyone has an individual experience. What causes it, how do we cope with it, what mechanisms are involved, what is the traditional view of pain and how is that being challenged today? Do we experience pain in the same way and how is emotional pain different from physical pain? What can our experience of pain tell us about ourselves and human consciousness? Is each individual human experience unique or are there experiences we can say apply across all of human consciousness? Is science a blunt instrument for examining subjective experience?With Patrick Wall, Professor of Physiology at St Thomas’ Hospital, London and author of Pain: The Science of Suffering; Semir Zeki, Professor of Neurobiology at University College, London.

Melvyn Bragg and guests discuss a question that has stalked the twentieth century: Intelligence. Since the first IQ tests were invented in 1905, the question of what makes Homo Sapiens stupid and what makes him clever has involved human kind in sterilisation, racism and misery. How do we define intelligence, how do we measure it; what are its origins and how do we uncover it? But are we any closer to understanding what this elusive quality of intelligence is? The debate still rages as to whether we are born with it or whether intelligence is something we develop as we grow, and evidence for either camp seems to pile up almost daily. With Dr Ken Richardson, educational psychologist, former Senior Lecturer, Open University and author of The Making of Intelligence; Professor Michael Ruse Philosopher of Biology, University of Guelph, Ontario and author of Mystery of Mysteries: Is Evolution a Social Construction?

Melvyn Bragg and guests discuss the shift that has gone on through the 20th century from our being an industrial society to what is often called ‘the information society’. Francis Fukuyama’s book, The Great Disruption talks of the third great shift in the whole history of humankind. Along with all the technological and economic changes, in the past thirty years we have seen massive social changes. What has been the cause of this shift and how will we recover the social cohesion that preceded it? With Francis Fukuyama, Hirst Professor of Public Policy, George Mason University, Washington DC and author of The Great Disruption: Human Nature and the Reconstitution of Social Order; Amos Oz, author and Professor of Hebrew Literature, Ben-Gurion University, Beer-Sheva.

Melvyn Bragg and guests discuss memory. At the start of the twentieth century Freud put memory at the centre of our psychology, and as the century has worn on what a nation remembers and what it should try to forget has become one of the binding political questions that modern societies face. As every second passes, humanity has a moment more to remember, and perhaps this fact alone goes a long way to explaining the ever changing role of memory, both in the mind of individuals and at the heart of the body politic. Memory, what to remember and when to forget, has personal and national implications. Whether we look to Chile, South Africa, Germany or Northern Ireland, these are all societies where the issue of memory is at the centre of the dilemmas and challenges they face. And in the mind of the individual too - as ever more forms of information crowd for space in our minds, and the image from someone else’s photograph can be more enduring than our own first hand experience of an event, can memory itself forever remain unchanged in its role within our psychology? Have our ways of remembering changed? Not in the sense neuro-biologists would explore the subject, but in its cultural and collective, as well as its individual, sense. “Memory is decidedly in fashion” writes Dr Nancy Wood, “whether attention is focused on the so-called return of repressed memories of the abused individual, or on the black holes in a nation’s recollection of its past. The topic of memory has become a compelling preoccupation”. With Professor Malcolm Bowie, Marshall Foch Professor of French Literature at Oxford University and Director of Oxford’s European Humanities Research Centre; Dr Nancy Wood, Chair of Media Studies, University of Sussex and author of Vectors of Memory.

Melvyn Bragg examines the history of what we know about the origins of the universe. Some four hundred years ago in Rome, one Giordano Bruno was burnt at the stake for his belief in other inhabited worlds - it’s a possibility which has fascinated scientists, writers, artists and the general public for centuries - and any consideration of the origins of life and matter on other planets, and indeed this one, inevitably raises huge questions. Do other worlds exist? How did our planet come into existence? How can we know anything at all about the origins of life and matter so many billions of years ago, and how has our thinking on these - amongst the deepest of questions - changed over the 20th century? Are we any closer to knowing whether other worlds exist and how our own planet came into being? And does the knowledge we have about these things change our perception of ourselves and our position in the universe?With Professor Sir Martin Rees, Astronomer Royal and Royal Society Research Professor in Astronomy and Physics, Cambridge University; Professor Paul Davies, theoretical physicist and Visiting Professor at Imperial College, London.

Melvyn Bragg and guests discuss the way perceptions of the importance of mathematics have fluctuated in the 20th century, the nature of mathematical ability, and what mathematics can show us about how life began, and how it might continue. Galileo wrote “this grand book the universe… is written in the language of mathematics”. It was said before Galileo and has been said since and in the last decades of the 20th century it is being said again, most emphatically. How important is maths in relation to other sciences at the end of the twentieth century - will it ever be made redundant, or is it increasingly crucial to our understanding of the world and ourselves? What insight can it give us into the origins of life, and the functioning of our brains, and what does it mean to say that maths has become more ‘visual’?With Ian Stewart, Professor of Mathematics and Gresham Professor of Geometry, University of Warwick; Brian Butterworth, Professor of Cognitive Neuroscience, University College, London.